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Full-Text Articles in Medicine and Health Sciences
Model Studies Towards The Total Synthesis Of The Stemona Alkaloid 1-Hydroxyprotostemonine: Synthesis Of Ent-1-Hydroxystemoamide, Nalivela Kumara Swamy, Stephen G. Pyne
Model Studies Towards The Total Synthesis Of The Stemona Alkaloid 1-Hydroxyprotostemonine: Synthesis Of Ent-1-Hydroxystemoamide, Nalivela Kumara Swamy, Stephen G. Pyne
Faculty of Science, Medicine and Health - Papers: part A
As part of a model study towards the total synthesis of Stemona alkaloid 1-hydroxyprotostemonine 1, we have achieved the synthesis an A-B-C ring precursor, ent-1-hydroxystemoamide. Key steps involve an ene-yne RCM reaction and a diastereoselective dihydroxylation-lactonization reaction.
Is Seladin-1 Really A Selective Alzheimer's Disease Indicator?, Laura J. Sharpe, Jenny Wong, Brett Garner, Glenda M. Halliday, Andrew J. Brown
Is Seladin-1 Really A Selective Alzheimer's Disease Indicator?, Laura J. Sharpe, Jenny Wong, Brett Garner, Glenda M. Halliday, Andrew J. Brown
Faculty of Science, Medicine and Health - Papers: part A
Selective Alzheimer's Disease Indicator-1 (Seladin-1) was originally identified by its down-regulation in the brains of Alzheimer's disease (AD) patients. Here, we re-examine existing data and present new gene expression data that refutes its role as a selective AD indicator. Furthermore, we caution against the use of the name “Seladin-1” and instead recommend adoption of the approved nomenclature, 3β-hydroxysterol Δ24-reductase (or DHCR24), which describes its catalytic function in cholesterol synthesis. Further work is required to determine what link, if any, exists between DHCR24 and AD.