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Full-Text Articles in Medicine and Health Sciences
Saturated- And N-6 Polyunsaturated-Fat Diets Each Induce Ceramide Accumulation In Mouse Skeletal Muscle: Reversal And Improvement Of Glucose Tolerance By Lipid Metabolism Inhibitors, G Frangioudakis, J Garrard, K Raddatz, J L. Nadler, Todd W. Mitchell, Carsten Schmitz-Peiffer
Saturated- And N-6 Polyunsaturated-Fat Diets Each Induce Ceramide Accumulation In Mouse Skeletal Muscle: Reversal And Improvement Of Glucose Tolerance By Lipid Metabolism Inhibitors, G Frangioudakis, J Garrard, K Raddatz, J L. Nadler, Todd W. Mitchell, Carsten Schmitz-Peiffer
Faculty of Health and Behavioural Sciences - Papers (Archive)
Lipid-induced insulin resistance is associated with intracellular accumulation of inhibitory intermediates depending on the prevalent fatty acid (FA) species. In cultured myotubes, ceramide and phosphatidic acid (PA) mediate the effects of the saturated FA palmitate and the unsaturated FA linoleate, respectively. We hypothesized that myriocin (MYR), an inhibitor of de novo ceramide synthesis, would protect against glucose intolerance in saturated fat-fed mice, while lisofylline (LSF), a functional inhibitor of PA synthesis, would protect unsaturated fat-fed mice. Mice were fed diets enriched in saturated fat, n-6 polyunsaturated fat, or chow for 6 wk. Saline, LSF (25 mg/kg · d), or MYR …
Plasticity Of Oxidative Metabolism In Variable Climates: Molecular Mechanisms, Frank Seebacher, Martin D. Brand, Paul Else, Helga Guderley, Anthony J. Hulbert, Christopher D. Moyes
Plasticity Of Oxidative Metabolism In Variable Climates: Molecular Mechanisms, Frank Seebacher, Martin D. Brand, Paul Else, Helga Guderley, Anthony J. Hulbert, Christopher D. Moyes
Faculty of Health and Behavioural Sciences - Papers (Archive)
Converting food to chemical energy (ATP) that is usable by cells is a principal requirement to sustain life. The rate of ATP production has to be sufficient for housekeeping functions, such as protein synthesis and maintaining membrane potentials, as well as for growth and locomotion. Energy metabolism is temperature sensitive, and animals respond to environmental variability at different temporal levels, from within‐individual to evolutionary timescales. Here we review principal molecular mechanisms that underlie control of oxidative ATP production in response to climate variability. Nuclear transcription factors and coactivators control expression of mitochondrial proteins and abundance of mitochondria. Fatty acid and …
Dietary Fats And Membrane Function: Implications For Metabolism And Disease, Anthony J. Hulbert, Nigel Turner, Leonard H. Storlein, Paul Else
Dietary Fats And Membrane Function: Implications For Metabolism And Disease, Anthony J. Hulbert, Nigel Turner, Leonard H. Storlein, Paul Else
Faculty of Health and Behavioural Sciences - Papers (Archive)
Lipids play varied and critical roles in metabolism, with function dramatically modulated by the individual fatty acid moities in complex lipid entities. In particular, the fatty acid composition of membrane lipids greatly influences membrane function. Here we consider the role of dietary fatty acid profile on membrane composition and, in turn, its impact on prevalent disease clusters of the metabolic syndrome and mental illness. Applying the classical physiological conformer-regulator paradigm to quantify the influence of dietary fats on membrane lipid composition (i.e. where the membrane variable is plotted against the same variable in the environment - in this case dietary …