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Impaired Overload-Induced Hypertrophy Is Associated With Diminished Mtor Signaling In Insulin-Resistant Skeletal Muscle Of The Obese Zucker Rat, Anjaiah Katta, Sudarsanam Kundla, Sunil Kakarla, Miaozong Wu, Jacqueline Fannin, Satyanarayana Paturi, Hua Liu, Hari Addagarla, Eric Blough
Impaired Overload-Induced Hypertrophy Is Associated With Diminished Mtor Signaling In Insulin-Resistant Skeletal Muscle Of The Obese Zucker Rat, Anjaiah Katta, Sudarsanam Kundla, Sunil Kakarla, Miaozong Wu, Jacqueline Fannin, Satyanarayana Paturi, Hua Liu, Hari Addagarla, Eric Blough
Eric Blough
Recent data have suggested that insulin resistance may be associated with a diminished ability of skeletal muscle to undergo hypertrophy (Paturi S, Gutta AK, Kakarla SK, Katta A, Arnold EC, Wu M, Rice KM, Blough ER. J Appl Physiol 108: 7–13, 2010). Here we examine the effects of insulin resistance using the obese Zucker (OZ) rat with increased muscle loading on the regulation of the mammalian target of rapamycin (mTOR) and its downstream signaling intermediates 70-kDa ribosomal protein S6 kinase (p70S6k), ribosomal protein S6 (rpS6), eukaryotic elongation factor 2 (eEF2), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). Compared with …