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Therapeutic Application Of Carbon Monoxide In Acute Limb Compartment Syndrome, Aurelia Bihari
Therapeutic Application Of Carbon Monoxide In Acute Limb Compartment Syndrome, Aurelia Bihari
Electronic Thesis and Dissertation Repository
Acute limb compartment syndrome (CS), a devastating complication of musculoskeletal trauma, develops in response to elevation of the pressure within a closed osseofascial compartment, producing muscle- and limb-threatening ischemia. Full decompression of all involved compartments by fasciotomy is the current gold-standard therapy, but it must be performed within a surgical window of 6-8 hours, before tissue damage becomes permanent.
Carbon monoxide (CO), a byproduct of heme metabolism, has been shown protective in ischemia. While inhalation of CO leads to elevation of carboxyhemoglobin (COHb), recent development of transitional metal carbonyls, CO-releasing molecules (CO-RMs), particularly the water-soluble CORM-3, delivers CO in a …
Potential Therapeutic Role Of Hydrogen Sulfide-Releasing Molecule Gyy4137 In A Rat Model Of Acute Compartment Syndrome., Moustafa Haddara
Potential Therapeutic Role Of Hydrogen Sulfide-Releasing Molecule Gyy4137 In A Rat Model Of Acute Compartment Syndrome., Moustafa Haddara
Electronic Thesis and Dissertation Repository
Acute limb compartment syndrome (ACS) causes a unique form of limb ischaemia, which induces intense inflammatory response resulting in microcirculatory dysfunction, neutrophil activation and cell injury. Increased intracompartmental pressure is the hallmark of ACS. Decompression by fasciotomy is the gold standard treatment. While fasciotomy saves the limb from ischaemic threat, paradoxically, it causes further damage to the muscle by reperfusion injury. In addition, it does not address the inflammatory element purported to increase the tissue injury in ACS.
Recent evidence suggests that hydrogen sulfide (H2S) can mitigate the damage associated with ischaemia-reperfusion injury. The purpose of this thesis …