Medicine and Health Sciences Commons^™

A Computational Model Of Multiple Interconnected Capillary Modules In Skeletal Muscle, Raashi Vijay

Electronic Thesis and Dissertation Repository

Background: Skeletal muscle (SM), with its precise O₂ supply-demand matching, is ideal for studying microvascular (MV) function, which is crucial in cardiovascular physiology and disease. Our goal is to gain understanding of SM microcirculation using recent capillary network module (CM) data from rat in a computational model.

Methods: We construct a 4-CM network, with single-vessel equivalents for each CM, three arterioles, and two venules. A two-phase (plasma/RBCs) steady-state model is used to calculate blood flow. An iterative boundary pressure finding method is developed to match flow in CMs.

Results: We validate our flow and pressure models …

Exploring Novel Intradialytic Techniques To Identify & Ameliorate Of Hemodialysis-Induced Myocardial Ischemic Injury, Jarrin D. Penny

Electronic Thesis and Dissertation Repository

Patients with chronic kidney disease requiring hemodialysis to sustain life have extremely high rates of cardiovascular morbidity/mortality. This is both a consequence of the disease process and treatment. Hemodialysis induces systemic circulatory stress is largely due to the extracorporeal circuit and volume removal. The stress induced by intermitted hemodialysis is repetitive with cumulative cardiovascular effect and is the principal driver of heart failure and sudden death in this vulnerable population. The insults imposed by hemodialysis result in left ventricular regional wall motion abnormalities and lead to myocardial stunning with permanent damage to the vasculature and myocardium. Currently, the adversity caused …