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Full-Text Articles in Medicine and Health Sciences
Exploring The Relationship Between Early Severity Of Epilepsy And Depressive Symptoms In Youth Ten Years After Diagnosis, Samanpreet Brar
Exploring The Relationship Between Early Severity Of Epilepsy And Depressive Symptoms In Youth Ten Years After Diagnosis, Samanpreet Brar
Electronic Thesis and Dissertation Repository
This study assessed the association between early severity of epilepsy and subsequent depressive symptoms in youth and the extent to which family and clinical factors mediated this relationship. Data were obtained from the Health-Related Quality of Life in Children with Epilepsy Study, a multi-centre prospective study of children with new-onset epilepsy. A multiple linear regression analysis revealed severity of epilepsy 2 years post-diagnosis to be positively associated with depressive symptoms 10 years post-diagnosis (b=2.10, 95%CI:0.42,3.79). The results of generalized estimating equation models found family functioning, family resources, parental depressive symptoms, and antiepileptic drug use to not be mediators. Five-year seizure …
Fatigue In Children And Adolescents With Duchenne Muscular Dystrophy, Basmah El-Aloul
Fatigue In Children And Adolescents With Duchenne Muscular Dystrophy, Basmah El-Aloul
Electronic Thesis and Dissertation Repository
Fatigue was recently reported to be the largest predictor of poor health-related quality of life (HRQOL) in children and adolescents with Duchenne muscular dystrophy (DMD). The objectives of this thesis were to describe fatigue from patients’ and parents’ perspectives and to explore associations of patient characteristics with fatigue in children and adolescents with DMD using a multicentre cross-sectional study design. Eligible patients and their parents were identified via the Canadian Neuromuscular Disease Registry and received mailed paper questionnaires. Children and adolescents with DMD experienced greater fatigue compared to healthy controls from published data. Fatigue was a significant issue in children …