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Full-Text Articles in Medicine and Health Sciences
Trpm2 In The Central Nervous System: Physiological Role And Critical Regulatory Pathways, Jillian C. Belrose
Trpm2 In The Central Nervous System: Physiological Role And Critical Regulatory Pathways, Jillian C. Belrose
Electronic Thesis and Dissertation Repository
TRPM2 is a non-selective cation channel which is permeable to calcium. Although expression is highest in the brain, the physiological role for TRPM2 in neurons was unknown. Furthermore, our understanding of the pathways regulating TRPM2 channel function required further investigation. In this thesis, we identified that TRPM2 is required for NMDAR-dependent long-term depression (LTD). No change in NMDAR expression or function was observed following genetic deletion of TRPM2. Instead, the loss of NMDAR-LTD in TRPM2 knockout mice results from diminished GSK-3β activation. We next examined whether age in vitro could facilitate TRPM2 currents. We demonstrate that diminished glutathione with age …
Reductions In Muscle Quantity And Quality In Old And Very Old Men: New Insights Into The Progression Of Sarcopenia, William J. Booth
Reductions In Muscle Quantity And Quality In Old And Very Old Men: New Insights Into The Progression Of Sarcopenia, William J. Booth
Electronic Thesis and Dissertation Repository
Healthy adult aging is associated with sarcopenia; a loss of skeletal muscle mass known as. Major contributors to this process include functional and morphological changes in the contractile tissue and within the neuromuscular system. Currently, the relationship between muscle mass, normalized strength, structural integrity, and neuromuscular properties [such as motor unit number estimates (MUNE)], in the tibialis anterior (TA) with aging is largely unknown. Therefore, to examine this relationship we recruited twelve young (25 ± 3 years old), six old (68 ± 5 years old) and six very old (79 ± 3 years old) men. Magnetic resonance (MR) images were …