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Full-Text Articles in Medicine and Health Sciences
Investigating The Role Of Endogenous Atf4 Upregulation On Neuronal Glutathione Level, Fatemeh Mirshafiei
Investigating The Role Of Endogenous Atf4 Upregulation On Neuronal Glutathione Level, Fatemeh Mirshafiei
Electronic Thesis and Dissertation Repository
ATF4 is a transcription factor that is activated in response to integrated stress response (ISR). In neurons specifically, ATF4 has been suggested to act as a pro-apoptotic transcription factor. The expression of ATF4, as well as its downstream gene targets have been implicated in both in vivo and in vitro models of Alzheimer’s and Parkinson’s Disease. However, the mechanism by which ATF4 promotes cell death remains unclear. It was previously shown that overexpression of ATF4 in primary cortical neurons caused a reduction in glutathione levels, resulting in oxidative stress-induced cell death. The aim of this project was to investigate whether …
Mechanisms Of Atf4-Mediated Neuronal Apoptosis, Patrick Swan
Mechanisms Of Atf4-Mediated Neuronal Apoptosis, Patrick Swan
Electronic Thesis and Dissertation Repository
Abstract to be provided