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Describing Functional Brain Connectivity's Role In The Relationship Of Multimodal Interventions To Improve Cognitive And Physical Function In Vulnerable (Frailty & Mild Cognitive Impairment) Older Adults., Nicholas (Nick) W. Bray
Describing Functional Brain Connectivity's Role In The Relationship Of Multimodal Interventions To Improve Cognitive And Physical Function In Vulnerable (Frailty & Mild Cognitive Impairment) Older Adults., Nicholas (Nick) W. Bray
Electronic Thesis and Dissertation Repository
Aging is associated with declining cognitive and physical function. The decline accelerates in older adults diagnosed with mild cognitive impairment (MCI), a pre-dementia state, and frailty, a state of decreased physiological reserve. Previous work shows that frailty modifies the relationship between dementia pathology and clinical symptoms. Functional brain network connectivity (FBNC) refers to brain areas that are anatomically separate but temporally related in their neural signaling; it is believed to enable the completion of complex cognitive and physical functions. FBNC is considered a sensitive biomarker for monitoring the progression of dementia syndromes and investigating the efficacy of interventional strategies. Therefore, …