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- Alzheimer disease (1)
- Atrophy (1)
- Biomechanics (1)
- Botulinum toxin type A (1)
- Choline acetyltransferase (1)
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- Chromatin immunoprecipitation (1)
- Chromatin organization (1)
- Epigenetics (1)
- Essential tremor (1)
- Focal therapy (1)
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- Mild cognitive impairment (1)
- Online Motor Control (1)
- Parkinson's Disease; Automaticity; Perception; Bradykinesia; Dopaminergic Therapy (1)
- Parkinson's disease (1)
- Resting state function magnetic resonance imaging (1)
- Scaffolding/matrix attachment regions (1)
- Super-resolution microscopy (1)
- Upper limb (1)
Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
A Non-Canonical Role For Choline Acetyltransferase In Chromatin Organization And The Response To Beta-Amyloid, Warren R. Winick-Ng
A Non-Canonical Role For Choline Acetyltransferase In Chromatin Organization And The Response To Beta-Amyloid, Warren R. Winick-Ng
Electronic Thesis and Dissertation Repository
The three-dimensional structure of chromatin is essential for context-dependent regulation of gene expression in post-mitotic neurons. Chromosomal rearrangements have been observed in the aging brain, and proteins involved in chromatin organization have altered expression and/or localization in Alzheimer’s disease (AD). A human- and primate-specific transcript of choline acetyltransferase produces an 82-kDa protein (82-kDa ChAT) that is localized to the nucleus of cholinergic neurons, but is found in the cytoplasm in individuals with mild cognitive impairment (MCI) and AD. The function of the 82-kDa ChAT protein is unknown, though recent evidence suggests it has a role in gene expression changes in …
Development Of Anatomical And Functional Magnetic Resonance Imaging Measures Of Alzheimer Disease, Samaneh Kazemifar
Development Of Anatomical And Functional Magnetic Resonance Imaging Measures Of Alzheimer Disease, Samaneh Kazemifar
Electronic Thesis and Dissertation Repository
Alzheimer disease is considered to be a progressive neurodegenerative condition, clinically characterized by cognitive dysfunction and memory impairments. Incorporating imaging biomarkers in the early diagnosis and monitoring of disease progression is increasingly important in the evaluation of novel treatments. The purpose of the work in this thesis was to develop and evaluate novel structural and functional biomarkers of disease to improve Alzheimer disease diagnosis and treatment monitoring. Our overarching hypothesis is that magnetic resonance imaging methods that sensitively measure brain structure and functional impairment have the potential to identify people with Alzheimer’s disease prior to the onset of cognitive decline. …
Is Online Motor Control Really Impaired In Parkinson's Disease?, Kate E. Merritt
Is Online Motor Control Really Impaired In Parkinson's Disease?, Kate E. Merritt
Electronic Thesis and Dissertation Repository
Patients with Parkinson’s disease (PD) are thought to be selectively impaired in consciously-mediated online automatic motor control, whereas the ability to perform subconscious online adjustments remains intact. This present study evaluates the hypothesis that the previously alleged deficits in online motor control in PD are not due to the consciousness of the correction, but rather are attributable to aspects of the prior experimental designs disproportionately penalizing patients for PD-related bradykinesia. Here, we implemented a modified traditional double-step paradigm to investigate consciously-mediated online motor control in PD, in a manner that would be unconfounded by disease-related bradykinesia. Further, we investigated the …
Characterization And Personalization Of Botulinum Toxin Type A Therapy For Upper Limb Tremor In Parkinson Disease And Essential Tremor Patients Using Multi-Sensor Kinematic Technology, Olivia Samotus
Electronic Thesis and Dissertation Repository
Tremor commonly affects the upper extremities in essential tremor (ET) and Parkinson disease (PD) patients where many experience functional disability and ultimately seek therapy. As ET and PD tremor features overlap and clinical assessment is challenging due to its highly complex nature, misdiagnosis is common resulting in unsuitable therapies and prognosis. Current treatment options for ET and PD tremor include pharmacotherapy, focal therapy with botulinum toxin type A (BoNT-A) injections, and surgical interventions which provide modest relief of tremor. However, such therapies are commonly associated with significant adverse events and lack long-term efficacy and tolerability. Hence lack of standardized, objective …