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Full-Text Articles in Medicine and Health Sciences
Low Soluble Drug Encapsulation Based On Architecture Of Layer-By-Layer Assembly For Longer Circulation Time And Targeted Therapy, Pravin Pattekari
Low Soluble Drug Encapsulation Based On Architecture Of Layer-By-Layer Assembly For Longer Circulation Time And Targeted Therapy, Pravin Pattekari
Doctoral Dissertations
A combined effect of sonication and layer-by-layer assembly (LbL) enhances the solubility of many poorly soluble inorganic and organic materials by forming stable particles with ca. 200 nm size and up to 90 wt% of loading. The entire method is reproducible, easy-to-handle, and flexible for varying surface properties according to the application of the materials. The method develops good colloidal stability of materials in buffers and maintains architecture for future improvement. A top-down approach, with a combined effect of sonication and LbL assembly, ruptures the material and allows adsorption of oppositely charged polyelectrolytes simultaneously. Thus, the approach is applicable for …
Effects Of Untrained Earmold Impression Taking On Custom Hearing Protector Device Performance, Kelly R. Pack
Effects Of Untrained Earmold Impression Taking On Custom Hearing Protector Device Performance, Kelly R. Pack
Doctoral Dissertations
Today's consumer is increasingly turning to the internet for both healthcare information as well as the purchase of custom hearing protection devices (HPDs). These HPDs are often cast from do-it-yourself home ear impression kits that include a syringe and silicone earmold impression material to be injected into the ear canal. Although not required by law, earmold impressions have typically been taken by medical professionals and other individuals formally trained in the procedures and safety measures of effective earmold impression taking. The main purpose of this study was to determine if do-it-yourself earmold impressions produce HPD's with lower attenuation levels than …
The Effect Of Network Transitions On Spontaneous Activity And Sycnhrony In Devloping Neural Networks, Jude P. J. Savarraj
The Effect Of Network Transitions On Spontaneous Activity And Sycnhrony In Devloping Neural Networks, Jude P. J. Savarraj
Doctoral Dissertations
Connectivity patterns of developing neural circuits and the effects of its dynamics on network behavior, particularly the emergence of spontaneous activity and synchrony, are not clear. We attempt to quantify anatomical connectivity patterns of rat cortical cultures during different stages of development. By culturing the networks on dishes embedded with micro electrode arrays, we simultaneously record electrical activity from multiple regions of the developing network and monitor its electrical behavior, particularly its tendency to fire spontaneously and to synchronize under certain conditions. We investigate possible correlations between changes in the network connectivity patterns and spontaneous electrical activity and synchrony. Cocultures …