Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Anticonvulsant And Procognitive Effect Of Nonimidazole Histamine H3r Receptor Antagonists /Inverse Agonists In Experimental Animal Models, Alaa Imad Alachkar
Anticonvulsant And Procognitive Effect Of Nonimidazole Histamine H3r Receptor Antagonists /Inverse Agonists In Experimental Animal Models, Alaa Imad Alachkar
Dissertations
Epilepsy is a common chronic neurological disorder accompanied by cognitive impairment. Available antiepileptic drugs (AEDs) have not been reported to have ameliorative effects on epilepsy-associated memory impairment. The potential of histamine H3 receptors (H3R) in several neuropsychiatric diseases, including epilepsy and Alzheimer’s disease, is well recognized. In this study, a series of H3R antagonists (1-16) were screened for their in vivo anticonvulsant effect in several acute-induced seizures in rats. Moreover, the procognitive effect of the most promising H3R antagonist was investigated in dizocilpine (DIZ)-induced amnesic effect applying several behavioral memory tests. Furthermore, the most promising H3R antagonist was assessed for …
Pulmonary And Systemic Pathophysiological Impact Of Silver Nanoparticles: Effects Of Coating, Time, And Dose, Zannatul Ferdous
Pulmonary And Systemic Pathophysiological Impact Of Silver Nanoparticles: Effects Of Coating, Time, And Dose, Zannatul Ferdous
Dissertations
Nanotechnology is rapidly developing, and engineered materials (ENMs) are utilized in a wide array of end-user products owing to their unique physicochemical properties. Of the various forms of ENMs, silver nanoparticles (AgNPs) have gained much attention for potential uses in commercial applications. Due to their unique features, particularly antimicrobial properties, there had been a surge in the production of AgNPs-based products, hence increasing the potential of both occupational and consumer exposure. Among the various routes of human exposure, pulmonary exposure to AgNPs has received increased interest due to their potential to cause pulmonary injury, cross the alveolar-capillary barrier, and distribute …