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Effects Of Meloxicam And Etoricoxib On Blood Pressure And Vascular Reactivity In Rats, P Trongtorsak, S Sukpat, D Buapool, K. Thornola

Chulalongkorn Medical Journal

Background : Treatment with selective cyclooxygenase-2 (COX-2) inhibitor is associated with increased risk of cardiovascular events. Inhibition of COX-2 reduces vascular prostacyclin synthesis without disrupting COX-1-derived thromboxane synthesis, which may alter vascular tone and responsiveness. Objective : To examine the effects of two COX-2 inhibitors, meloxicam and etoricoxib, on blood pressure and vascular reactivity in rats. Methods : Unconscious blood pressure was obtained from Sprague Dawley rats by a tail-cuff method, and then the rats were divided into 3 groups (n = 9 in all groups): 1) non - treated control, 2) meloxicam 1 mg/kg/d, 3) etoricoxib 3 mg/kg/d. Drugs …