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Validation Of The Chads2 Clinical Prediction Rule To Predict Ischaemic Stroke. A Systematic Review And Meta-Analysis., Claire Keogh, Emma Wallace, Ciara Dillon, Borislav Dimitrov, Tom Fahey
Validation Of The Chads2 Clinical Prediction Rule To Predict Ischaemic Stroke. A Systematic Review And Meta-Analysis., Claire Keogh, Emma Wallace, Ciara Dillon, Borislav Dimitrov, Tom Fahey
Borislav D Dimitrov
The CHADS2 predicts annual risk of ischaemic stroke in non-valvular atrial fibrillation. This systematic review and meta-analysis aims to determine the predictive value of CHADS2. The literature was systematically searched from 2001 to October 2010. Data was pooled and analysed using discrimination and calibration statistical measures, using a random effects model. Eight data sets (n = 2815) were included. The diagnostic accuracy suggested a cut-point of ≥ 1 has higher sensitivity (92%) than specificity (12%) and a cut-point of ≥ 4 has higher specificity (96%) than sensitivity (33%). Lower summary estimates were observed for cut-points ≥ 2 (sensitivity 79%, specificity …