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Full-Text Articles in Medicine and Health Sciences
Influence Of Metabolic Capacity On The Consequences Of Spreading Depolarization, Katelyn M. Reinhart
Influence Of Metabolic Capacity On The Consequences Of Spreading Depolarization, Katelyn M. Reinhart
Biomedical Sciences ETDs
In the United States, stroke is the fifth leading cause of death and stroke survivors often face long-term disability. After ischemic stroke, the ischemic territory can expand and recruit previously viable tissues into the lesioned area. During this critical period, there is an unsettling lack of interventions that prevent or treat secondary neuronal loss and cognitive decline. Clinical subdural recordings have revealed a close link between infarct progression and waves of spreading depolarizations (SD) in the acutely injured brain. SD is a slowly progressing wave of near-complete neuroglia depolarization that is extremely energetically demanding and this additional metabolic ‘hit’ …
Prenatal Alcohol Exposure Alters Histamine H3 Receptor Modulation Of Glutamate Release And Long-Term Potentiation In The Rat Dentate Gyrus, Rafael Varaschin
Prenatal Alcohol Exposure Alters Histamine H3 Receptor Modulation Of Glutamate Release And Long-Term Potentiation In The Rat Dentate Gyrus, Rafael Varaschin
Biomedical Sciences ETDs
Children with Fetal Alcohol Spectrum Disorder exhibit long lasting behavioral impairments, such as learning disabilities, problems in executive functioning and memory deficits. Currently, there are no rationally designed, clinically available pharmacological tools to circumvent prenatal alcohol-induced cognitive deficits. Recently, using a rat model of voluntary drinking during pregnancy, Savage and collaborators (2010) showed that the inverse agonist of histamine H3 receptors reverses fetal ethanol-induced deficits in learning and memory, without further increasing cognition in control rats. These differential effects and the notion that H3 receptors reside in presynaptic nerve terminals to inhibit neurotransmitter release, led to the hypothesis that fetal …