Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Role Of The Acid Sensing Ion Channel 1a In The Systemic Circulation, Selina M. Garcia
Role Of The Acid Sensing Ion Channel 1a In The Systemic Circulation, Selina M. Garcia
Biomedical Sciences ETDs
Acid-sensing ion channel 1a (ASIC1a) is a non-selective cation channel that is expressed in vascular smooth muscle cells. However, little is known about the contribution of ASIC1a to vascular reactivity and cardiovascular homeostasis. We have previously shown that ASIC1a contributes to pulmonary vascular smooth muscle cell (VSMC) Ca2+ entry and vasoconstriction as well as chronic hypoxia-induced pulmonary hypertension. However, a role of ASIC1a in the systemic circulation is unclear. Previous reports have shown that ASIC1a is expressed in femoral and cerebral arteries, however, these studies suggest that ASIC1a contributes to vascular reactivity through neuronal regulation rather than vascular. Therefore, …
Mechanisms Responsible For Decreased Rat Pulmonary Arterial H2o2 Levels In A Model Of Chronic Hypoxia-Induced Pulmonary Hypertension, Danielle Plomaritas
Mechanisms Responsible For Decreased Rat Pulmonary Arterial H2o2 Levels In A Model Of Chronic Hypoxia-Induced Pulmonary Hypertension, Danielle Plomaritas
Biomedical Sciences ETDs
Our laboratory has demonstrated an important role for acid-sensing ion channel 1 (ASIC1) in pulmonary hypertension through augmented Ca2+ influx in pulmonary arterial smooth muscle cells (PASMC) following chronic hypoxia (CH). However, this enhanced calcium (Ca2+) influx is not dependent on an increase in ASIC1 protein expression. This suggests other regulatory mechanisms influencing ASIC1 activity are altered following CH. ASIC1 is a redox sensitive ion channel and recent studies from our laboratory have shown that the oxidant hydrogen peroxide (H2O2) inhibits ASIC1-dependent Ca2+ influx in PASMC. Reactive oxygen species are known to be altered in pulmonary hypertension, however the direction …