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Selective Inhibition Of Intestinal Amino Acid Transport By Three Heavy Metals, Verney Lee Sallee

Biomedical Sciences ETDs

Intestinal absorption of neutral amino acids, an active transport process, selects certain amino acids for transfer on the basis of their chemical structure. However, within the group of transported neutral amino acids, selectivity into secondary groups is not readily apparent, and only a relative variation of transport rate for each amino acid has been noted. A popular hypothesis, consistent with previously reported experimental observations, holds that intestinal transport of neutral amino acids occurs through mediation of one transport system with one effective binding site.

Studies On The Physiology Of Infection Of Micrococcus Studies On The Physiology Of Infection Of Micrococcus Lysodeikticus By Bacteriophage N1.Lysodeikticus By Bacteriophage N1, John Arthur Mayo

Biomedical Sciences ETDs

The experiments reported in this dissertation were aimed at studying two problems. The first of these was the occurrence and role of DNA rings in cells of Micrococcus lysodeikticus infected by any of several bacteriophages, particularly bacteriophage N1. Difficulties in labeling vegetative N1 DNA with radioactive pre­cursors led to the second problem, utilization of nucleosides by bacteriophage N1-infected N1-lysodeikticus.

It had been shown previously that N1-infected M. lysodeikticus contains during the latent period a DNA ring of the same molecular weight as the linear DNA isolated from the intact phage.

This result was confirmed and extended to include M. lysodeikticus …

Studies On Antibody Mediated Suppression Of The Immune Response, John W. Safford Jr.

Biomedical Sciences ETDs

It is well known that passive antibody will specifically suppress an immune response to the corresponding antigen. The goal of this study was to determine if passive antibody had any effect on the development of immunological memory. The nature of the immune response to a second injection of sheep red blood cells (SRBC) following a primary immune response suppressed by passive antibody was investigated. C57Bl/Ks mice received a primary injection of SRBC and homologous anti-SRBC serum; 14 days later they were challenged with a second injection of SRBC. The immune response was evaluated by determining the number of cells synthesizing …