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Full-Text Articles in Medicine and Health Sciences
Frequently Used Antiemetic Agent Dexamethasone Enhances The Metastatic Behaviour Of Select Breast Cancer Cells, Martin Crozier, Janice Tubman, Bre Anne Fifield, Rosa Maria Ferraiuolo, Jenna Ritchie, Katie Zuccato, Emily Mailloux, Indrajit Sinha, Caroline Hamm, Lisa A. Porter
Frequently Used Antiemetic Agent Dexamethasone Enhances The Metastatic Behaviour Of Select Breast Cancer Cells, Martin Crozier, Janice Tubman, Bre Anne Fifield, Rosa Maria Ferraiuolo, Jenna Ritchie, Katie Zuccato, Emily Mailloux, Indrajit Sinha, Caroline Hamm, Lisa A. Porter
Biomedical Publications
Glucocorticoids, such as dexamethasone (Dex), are used to prevent common side effects induced by chemotherapy and are heavily prescribed for solid cancers such as breast cancer. There is substantial pre-clinical data to support that Dex activation of the glucocorticoid receptor overrides chemotherapy-induced apoptosis in breast cancer cell lines. These findings are compounded by a recent study demonstrating that increased glucocorticoid receptor activation by endogenous stress hormones increased breast cancer heterogeneity and metastasis. Our study is the first to use both in vitro and in vivo models to thoroughly compare the Dex response on the migration of multiple estrogen receptor negative …
Addressing The Barriers To Clinical Trials Accrual In Community Cancer Centres Using A National Clinical Trials Navigator:A Cross-Sectional Analysis, Caroline Hamm, Dora Cavallo-Medved, Devinder Moudgil, Lee Mcgrath, John Huang, Yueyang Li, Tyler W. Stratton, Tyler Robinson, Krista Naccarato, Stephen Sundquist, Janet Dancey
Addressing The Barriers To Clinical Trials Accrual In Community Cancer Centres Using A National Clinical Trials Navigator:A Cross-Sectional Analysis, Caroline Hamm, Dora Cavallo-Medved, Devinder Moudgil, Lee Mcgrath, John Huang, Yueyang Li, Tyler W. Stratton, Tyler Robinson, Krista Naccarato, Stephen Sundquist, Janet Dancey
Biomedical Publications
Introduction: Clinical trials, although academically accepted as the most effective treatment available for cancer patients, poor accrual to clinical trials remains a significant problem. A clinical trials navigator (CTN) program was piloted where patients and/or their healthcare professionals could request a search and provide a list of potential cancer clinical trials in which a patient may be eligible based on their current status and disease. Objectives: This study examined the outcomes of a pilot program to try to improve clinical trials accrual with a focus on patients at medium to small sized cancer programs. Outcomes examined included patient disposition (referral …
Fitted Filtration Efficiency And Breathability Of 2-Ply Cotton Masks: Identification Of Cotton Consumer Categories Acceptable For Homemade Cloth Mask Construction, Ken G. Drouillard, Amanda Tomkins, Sharon Lackie, Scott Laengert, Allison Baker, Catherine M. Clase, Charles F. De Lannoy, Dora Cavallo-Medved, Lisa A. Porter, Rebecca S. Rudman
Fitted Filtration Efficiency And Breathability Of 2-Ply Cotton Masks: Identification Of Cotton Consumer Categories Acceptable For Homemade Cloth Mask Construction, Ken G. Drouillard, Amanda Tomkins, Sharon Lackie, Scott Laengert, Allison Baker, Catherine M. Clase, Charles F. De Lannoy, Dora Cavallo-Medved, Lisa A. Porter, Rebecca S. Rudman
Biomedical Publications
The objective of this study was to characterize commercially-available cotton fabrics to determine their suitability as materials for construction of cloth masks for personal and public use to reduce infectious disease spread. The study focused on cottons because of their widespread availability, moderate performance and they are recommended for inclusion in home-made masks by international health authorities. Fifty-two cottons were analyzed by electron microscopy to determine fabric characteristics and fabric weights. Sixteen fabrics were selected to test for breathability and to construct 2-ply cotton masks of a standard design to use in quantitative fit testing on a human participant. Cotton …