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Full-Text Articles in Medicine and Health Sciences
Characterization Of Disease-Related Covariance Topographies With Ssmpca Toolbox: Effects Of Spatial Normalization And Pet Scanners, S. C. Peng, Y. L. Ma, P. G. Spetsieris, P. Mattis, Andrew Feigin, V. Dhawan, D. Eidelberg
Characterization Of Disease-Related Covariance Topographies With Ssmpca Toolbox: Effects Of Spatial Normalization And Pet Scanners, S. C. Peng, Y. L. Ma, P. G. Spetsieris, P. Mattis, Andrew Feigin, V. Dhawan, D. Eidelberg
Journal Articles
To generate imaging biomarkers from disease-specific brain networks, we have implemented a general toolbox to rapidly perform scaled subprofile modeling (SSM) based on principal component analysis (PCA) on brain images of patients and normals. This SSMPCA toolbox can define spatial covariance patterns whose expression in individual subjects can discriminate patients from controls or predict behavioral measures. The technique may depend on differences in spatial normalization algorithms and brain imaging systems. We have evaluated the reproducibility of characteristic metabolic patterns generated by SSMPCA in patients with Parkinson's disease (PD). We used [F-18]fluorodeoxyglucose PET scans from patients with PD and normal controls. …
Evoked Effective Connectivity Of The Human Neocortex, L. Entz, E. Toth, C. J. Keller, S. Bickel, D. M. Groppe, D. Fabo, L. R. Kozak, L. Eross, I. Ulbert, A. D. Mehta
Evoked Effective Connectivity Of The Human Neocortex, L. Entz, E. Toth, C. J. Keller, S. Bickel, D. M. Groppe, D. Fabo, L. R. Kozak, L. Eross, I. Ulbert, A. D. Mehta
Journal Articles
The role of cortical connectivity in brain function and pathology is increasingly being recognized. While in vivo magnetic resonance imaging studies have provided important insights into anatomical and functional connectivity, these methodologies are limited in their ability to detect electrophysiological activity and the causal relationships that underlie effective connectivity. Here, we describe results of cortico-cortical evoked potential (CCEP) mapping using single pulse electrical stimulation in 25 patients undergoing seizure monitoring with subdural electrode arrays. Mapping was performed by stimulating adjacent electrode pairs and recording CCEPs from the remainder of the electrode array. CCEPs reliably revealed functional networks and showed an …
Comparative Definitions For Moderate-Severe Ischemia In Stress Nuclear, Echocardiography, And Magnetic Resonance Imaging, L. J. Shaw, D. S. Berman, M. H. Picard, G. W. Stone, R. Senior, J. K. Min, R. Hachamovitch, M. Scherrer-Crosbie, J. H. Mieres, P. S. Douglas, +19 Additional Authors
Comparative Definitions For Moderate-Severe Ischemia In Stress Nuclear, Echocardiography, And Magnetic Resonance Imaging, L. J. Shaw, D. S. Berman, M. H. Picard, G. W. Stone, R. Senior, J. K. Min, R. Hachamovitch, M. Scherrer-Crosbie, J. H. Mieres, P. S. Douglas, +19 Additional Authors
Journal Articles
The lack of standardized reporting of the magnitude of ischemia on noninvasive imaging contributes to variability in translating the severity of ischemia across stress imaging modalities. We identified the risk of coronary artery disease (CAD) death or myocardial infarction (MI) associated with >= 10% ischemic myocardium on stress nuclear imaging as the risk threshold for stress echocardiography and cardiac magnetic resonance. A narrative review revealed that >= 10% ischemic myocardium on stress nuclear imaging was associated with a median rate of CAD death or MI of 4.9%/year (interquartile range: 3.75% to 5.3%). For stress echocardiography, >= 3 newly dysfunctional segments …
Reliability Of Neuroanatomical Measurements In A Multisite Longitudinal Study Of Youth At Risk For Psychosis, T. D. Cannon, L. J. Seidman, H. W. Thermenos, B. A. Cornblatt, D. M. Olvet, D. Perkins, M. L. Qiu, D. H. Mathalon, P. Thompson, A. W. Toga, +19 Additional Authors
Reliability Of Neuroanatomical Measurements In A Multisite Longitudinal Study Of Youth At Risk For Psychosis, T. D. Cannon, L. J. Seidman, H. W. Thermenos, B. A. Cornblatt, D. M. Olvet, D. Perkins, M. L. Qiu, D. H. Mathalon, P. Thompson, A. W. Toga, +19 Additional Authors
Journal Articles
Multisite longitudinal neuroimaging designs are used to identify differential brain structural change associated with onset or progression of disease. The reliability of neuroanatomical measurements over time and across sites is a crucial aspect of power in such studies. Prior work has found that while within-site reliabilities of neuroanatomical measurements are excellent, between-site reliability is generally more modest. Factors that may increase between-site reliability include standardization of scanner platform and sequence parameters and correction for between-scanner variations in gradient nonlinearities. Factors that may improve both between- and within-site reliability include use of registration algorithms that account for individual differences in cortical …
Reliability Of Functional Magnetic Resonance Imaging Activation During Working Memory In A Multi-Site Study: Analysis From The North American Prodrome Longitudinal Study, J. K. Forsyth, C. E. Bearden, J. Addington, B. Goodyear, K. S. Cadenhead, H. Mirzakhanian, B. A. Cornblatt, D. M. Olvet, M. L. Qiu, T. D. Cannon, +13 Additional Authors
Reliability Of Functional Magnetic Resonance Imaging Activation During Working Memory In A Multi-Site Study: Analysis From The North American Prodrome Longitudinal Study, J. K. Forsyth, C. E. Bearden, J. Addington, B. Goodyear, K. S. Cadenhead, H. Mirzakhanian, B. A. Cornblatt, D. M. Olvet, M. L. Qiu, T. D. Cannon, +13 Additional Authors
Journal Articles
Multi-site neuroimaging studies offer an efficient means to study brain functioning in large samples of individuals with rare conditions; however, they present new challenges given that aggregating data across sites introduces additional variability into measures of interest. Assessing the reliability of brain activation across study sites and comparing statistical methods for pooling functional data are critical to ensuring the validity of aggregating data across sites. The current study used two samples of healthy individuals to assess the feasibility and reliability of aggregating multi-site functional magnetic resonance imaging (fMRI) data from a Sternberg-style verbal working memory task. Participants were recruited as …
Independent Component Analysis Of Resting State Activity In Pediatric Obsessive-Compulsive Disorder, P. Gruner, A. Vo, M. Argyelan, T. Ikuta, A. J. Degnan, M. John, B. D. Peters, A. K. Malhotra, A. M. Ulug, P. Szeszko
Independent Component Analysis Of Resting State Activity In Pediatric Obsessive-Compulsive Disorder, P. Gruner, A. Vo, M. Argyelan, T. Ikuta, A. J. Degnan, M. John, B. D. Peters, A. K. Malhotra, A. M. Ulug, P. Szeszko
Journal Articles
Obsessive-compulsive disorder (OCD) is an often severely disabling illness with onset generally in childhood or adolescence. Little is known, however, regarding the pattern of brain resting state activity in OCD early in the course of illness. We therefore examined differences in brain resting state activity in patients with pediatric OCD compared with healthy volunteers and their clinical correlates. Twenty-three pediatric OCD patients and 23 healthy volunteers (age range 9-17), matched for sex, age, handedness, and IQ completed a resting state functional magnetic resonance imaging exam at 3T. Patients completed the Children's Yale Brown Obsessive Scale. Data were decomposed into 36 …
Appropriate Use Of Ct Perfusion Following Aneurysmal Subarachnoid Hemorrhage: A Bayesian Analysis Approach, R. P. Killeen, A. Gupta, H. Delaney, C. E. Johnson, A. J. Tsiouris, M. E. Fink, H. S. Mangat, A. Z. Segal, A. I. Mushlin, P. C. Sanelli, +1 Additional Author
Appropriate Use Of Ct Perfusion Following Aneurysmal Subarachnoid Hemorrhage: A Bayesian Analysis Approach, R. P. Killeen, A. Gupta, H. Delaney, C. E. Johnson, A. J. Tsiouris, M. E. Fink, H. S. Mangat, A. Z. Segal, A. I. Mushlin, P. C. Sanelli, +1 Additional Author
Journal Articles
These investigators evaluated the test characteristics of CTP in patients with SAH for detection of delayed cerebral ischemia. Ninety-seven patients were assessed with CTP for ischemia and with DSA for vasospasm. The authors concluded that positive CTP findings identified patients who should be carefully considered for induced hypertension, hypervolemia, and hemodilution and/or intra-arterial therapy while negative CTP findings are useful in guiding a no-treatment decision. BACKGROUND AND PURPOSE: In recent years CTP has been used as a complementary diagnostic tool in the evaluation of delayed cerebral ischemia and vasospasm. Our aim was to determine the test characteristics of CTP for …
Ct Perfusion For Detection Of Delayed Cerebral Ischemia In Aneurysmal Subarachnoid Hemorrhage: A Systematic Review And Meta-Analysis, D. I. A. Mir, A. Gupta, A. Dunning, L. Puchi, C. L. Robinson, H. A. B. Epstein, P. C. Sanelli
Ct Perfusion For Detection Of Delayed Cerebral Ischemia In Aneurysmal Subarachnoid Hemorrhage: A Systematic Review And Meta-Analysis, D. I. A. Mir, A. Gupta, A. Dunning, L. Puchi, C. L. Robinson, H. A. B. Epstein, P. C. Sanelli
Journal Articles
BACKGROUND AND PURPOSE: Delayed cerebral ischemia is a significant cause of morbidity and mortality after aneurysmal SAH, leading to poor outcomes. The purpose of this study was to evaluate the usefulness of CTP in determining delayed cerebral ischemia in patients with aneurysmal SAH. MATERIALS AND METHODS: We conducted a systematic review evaluating studies that assessed CTP in patients with aneurysmal SAH for determining delayed cerebral ischemia. Studies using any of the following definitions of delayed cerebral ischemia were included in the systematic review: 1) new onset of clinical deterioration, 2) cerebral infarction identified on follow-up CT or MR imaging, and …
Does The Location Of The Arterial Input Function Affect Quantitative Ctp In Patients With Vasospasm?, B. J. Shin, N. Anumula, S. Hurtado-Rua, P. Masi, R. Campbell, R. Spandorfer, A. Ferrone, T. Caruso, A. Gupta, P. C. Sanelli, +2 Additional Authors
Does The Location Of The Arterial Input Function Affect Quantitative Ctp In Patients With Vasospasm?, B. J. Shin, N. Anumula, S. Hurtado-Rua, P. Masi, R. Campbell, R. Spandorfer, A. Ferrone, T. Caruso, A. Gupta, P. C. Sanelli, +2 Additional Authors
Journal Articles
BACKGROUND AND PURPOSE: In recent years, there has been increasing use of CTP imaging in patients with aneurysmal SAH to evaluate for vasospasm. Given the critical role of the arterial input function for generation of accurate CTP data, several studies have evaluated the effect of varying the arterial input function location in patients with acute stroke. Our aim was to determine the effect on quantitative CTP data when the arterial input function location is distal to significant vasospasm in patients with aneurysmal SAH. MATERIALS AND METHODS: A retrospective study was conducted of patients with aneurysmal SAH admitted from 2005 to …
Imaging And Treatment Of Patients With Acute Stroke: An Evidence-Based Review, P. C. Sanelli, J. B. Sykes, A. L. Ford, J. M. Lee, K. D. Vo, D. K. Hallam
Imaging And Treatment Of Patients With Acute Stroke: An Evidence-Based Review, P. C. Sanelli, J. B. Sykes, A. L. Ford, J. M. Lee, K. D. Vo, D. K. Hallam
Journal Articles
Evidence-based medicine has emerged as a valuable tool to guide clinical decision-making, by summarizing the best possible evidence for both diagnostic and treatment strategies. Imaging plays a critical role in the evaluation and treatment of patients with acute ischemic stroke, especially those who are being considered for thrombolytic or endovascular therapy. Time from stroke-symptom onset to treatment is a strong predictor of long-term functional outcome after stroke. Therefore, imaging and treatment decisions must occur rapidly in this setting, while minimizing unnecessary delays in treatment. The aim of this review was to summarize the best available evidence for the diagnostic and …
Delayed Cerebral Ischemia In Aneurysmal Subarachnoid Hemorrhage: Proposal Of An Evidence-Based Combined Clinical And Imaging Reference Standard, P. C. Sanelli, S. Kishore, A. Gupta, H. Mangat, A. Rosengart, H. Kamel, A. Segal
Delayed Cerebral Ischemia In Aneurysmal Subarachnoid Hemorrhage: Proposal Of An Evidence-Based Combined Clinical And Imaging Reference Standard, P. C. Sanelli, S. Kishore, A. Gupta, H. Mangat, A. Rosengart, H. Kamel, A. Segal
Journal Articles
Aneurysmal subarachnoid hemorrhage is associated with high morbidity and mortality, with delayed neurologic deficits from delayed cerebral ischemia contributing to a large portion of the adverse outcomes in this patient population. There is currently no consensus reference standard for establishing the diagnosis of delayed cerebral ischemia either in the research or clinical settings, ultimately limiting strategies for preventing delayed infarction and permanent neurologic deficits. There are currently both clinical and imaging-based criteria for the diagnosis of delayed neurologic deficits and vasospasm, respectively, however, neither clinical nor angiographic assessment alone has been shown to identify patients who develop adverse outcomes from …