Medicine and Health Sciences Commons^™

Process Modeling The Neuroprotective Effects Of A Plant-Based Diet On Parkinson's Disease, Julia Mitchell

Undergraduate Honors Theses

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor symptoms such as tremors, bradykinesia, rigidity, and postural instability. Recent research suggests an avenue for potential neuroprotection through dietary intervention, specifically the adoption of a plant-based diet. A plant-based diet predominantly comprises foods derived from plants, emphasizing fruits, vegetables, grains, legumes, and nuts while minimizing or excluding animal products. This thesis aims to explore the biochemical pathways implicated in PD progression and the potential impact of dietary choices on these pathways. The investigation focuses on several key pathways: alpha-synuclein aggregation, the blood-brain barrier crossing of levodopa, oxidative stress, ferroptosis, …

Mathematical Modeling And Examination Into Existing And Emerging Parkinson’S Disease Treatments: Levodopa And Ketamine, Gabrielle Riddlemoser

Undergraduate Honors Theses

Parkinson’s disease (PD) is the second most common neurodegenerative disease across the world, affecting over 6 million people worldwide. This disorder is characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta (SNpc) due to the aggregation of α-synuclein within the brain. Patients with PD develop motor symptoms such as tremors, bradykinesia, and postural instability, as well as a host of non-motor symptoms such as behavioral changes, sleep difficulties, and fatigue. The reduction of dopamine within the brain is the primary cause of these symptoms. The main form of treatment for PD is levodopa, a precursor …

Cognitive Decline And Contact Sports: The Relationship Between P3 Amplitude And Sub-Concussive Head Impact, Elizabeth Kerman

Undergraduate Honors Theses

The present study sought to explore the effect of repetitive sub-concussive head impacts on the P3 event-related potential (ERP) amplitude and measures of movement kinematics. University students participating in collision, contact, and non-contact sports at the club and varsity level completed a cued visuomotor adaptation task. Results indicated that participants who estimated experiencing four or more sub-concussive head impacts per week display a significantly reduced P3 amplitude across both normal and adaptive trials. Additionally, participants who estimated experiencing less than four sub-concussive head impacts per week displayed no significant changes in P300 amplitude between “switch” and “stay” trials. This research …

Modeling Perinatal Outcomes In Disaggregated Asian American Subgroups, Suditi Shyamsunder

Undergraduate Honors Theses

Asian mothers, as an aggregate, may be at increased risk for adverse perinatal outcomes, but heterogeneity between disaggregated Asian American subgroups is an understudied topic. The first objective of this study is to examine differences in perinatal outcomes between disaggregated Asian American subgroups and differences compared to Non-Hispanic Whites (NHWs). The second goal is to develop models to predict gestational diabetes, one perinatal outcome, in Asian Indian mothers to see how precision medicine may be able to advance pregnancy care. Using the National Vital Statistics System Natality Dataset (n=10,823,868), odds ratios (OR) were calculated with 95% confidence intervals (CI) for …

Synthesis And Biological Testing Of Small-Molecule Mitochondrial Complex I Inhibitors, Willough Sloan

Undergraduate Honors Theses

This thesis delineates two main projects: the first outlines the structure elucidation efforts toward a Diels-Alder adduct of a novel reaction for the synthesis of chimaphilin, a naphthoquinone-based natural product with apoptotic or antiproliferative activity in certain cancer cells^1,2. The structure elucidation extends to derivatives of chimaphilin synthesized by the same cyclization reaction. While Diels-Alder reactions are usually regioselective, ¹H-NMR and ¹³C-NMR of the adducts was inconclusive and indicated the possibility of regioisomer presence, with one regioisomer being chimaphilin (or derivatives). A multitude of crystallization methods were carried out in order to be able to analyze …

True Price Of A Pack: Tobacco Expenditure And Height-For-Age In Indonesia, Madeline Helfer

Undergraduate Honors Theses

While the negative impact of tobacco on the health of smokers is well known, the ways in which smoking impacts the health of the smoker’s children is less understood. This study explores whether tobacco expenditure increases the risk of stunting among children under the age of five in Indonesia, where smoking and stunting rates are among the highest in Southeast Asia. Given the severe income constraints faced by poor Indonesian households, large tobacco expenditure potentially “crowds-out” spending on nutrition, worsening the nutritional health of children in smoking households. To examine this relationship, I use a sample of children under the …

Student Sleep Patterns When Exposed To Mindfulness Reminders, Zeyanna Dhalla

Undergraduate Honors Theses

University students are plagued with increased levels of stress and anxiety which can lead to poor sleep quality and quantity. Breathing techniques have demonstrated counteractive effects to the chronic stresses that the population encounters on an everyday basis. Wearable technology, such as Apple Watches, contain a mindfulness feature that encourages its users to pause throughout the day and engage in mindfulness through resonant breathing. Wearable technology has become increasingly accessible and is also growing in accuracy to measure different biometrics such as sleep quality and quantity. The purpose of the present study was to examine if the mindfulness reminders initiated …

Machine Learning In Healthcare: Improving The Diagnosis Of Pulmonary Embolism In Covid-19 Patients, Soheb Osmani

Undergraduate Honors Theses

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created new challenges for clinicians diagnosing pulmonary embolism (PE). Clinicians currently rely on D-Dimer levels in conjunction with clinical prediction scores to rule out and diagnose PE. However, patients with COVID-19 (the disease caused by SARS-CoV-2) often present with elevated D-Dimer levels. D-Dimer levels in COVID-19 patients have been found to be positively correlated with the severity of disease. Symptoms of COVID-19 also often align with symptoms of PE. Therefore, it becomes more difficult for clinicians to identify which COVID-19 positive patients should undergo further testing for PE. This study evaluates …

A Mathematical Model Of Vagus Nerve Stimulation In Alzheimer's Disease, Julianne Miranda

Undergraduate Honors Theses

Alzheimer’s Disease is a neurodegenerative condition characterized by cognitive decline as a result of brain atrophy. The exact cause of Alzheimer’s is unknown but current theories involve the aggregation of amyloid beta plaques as well as neurofibrillary tangles. Inflammation is emerging as central to the progression of the disease, with increased amyloid beta plaques and neurofibrillary tangles associated with the Nuclear Factor Kappa B pathway. This project presents a mathematical model of the impact of vagus nerve stimulation in Alzheimer’s Disease, as seen through the Nuclear Factor Kappa B (NFKB) pathway. The model examines several factors involved in the inflammatory …

The Pandemic From Above: Estimating Covid-19 Cases Using Deep Learning And Satellite Imagery, John Hennin

Undergraduate Honors Theses

Monitoring the spread of an outbreak of disease (such as COVID-19) is an important component of any coordinated pandemic response. Across the globe, our ability to conduct such monitoring - especially at early stages of the COVID- 19 pandemic - was highly limited due to a lack of public reporting mechanisms. Today, the process of case data collection remains expensive and, in some regions, is subject to political considerations. Researchers have turned to some techniques leveraging Google Trends and Twitter data to overcome limitations in public data sources. Here, we provide another approach which leverages satellite information to provide estimates …

The Origins Of Inspiratory And Sigh Breathing Rhythms: Ion Channels, Bursting Mechanisms, And Synaptic Topologies Studied In Vitro And In Silico, Cameron J. Grover

Dissertations, Theses, and Masters Projects

Breathing is the rhythmic motor behavior which maintains homeostasis by driving gas exchange between our blood and the atmosphere. This behavior is essential for life in all terrestrial mammals. This behavior involves two distinct but coupled rhythms: the inspiratory rhythm, the normal breathing rhythm that occurs on the order of seconds, and the sigh rhythm, which produces large amplitude breaths that occur on the order of minutes and maintain pulmonary function. The rhythm for both behaviors and their control originates in a specialized neuronal region of the ventral medulla called the preBötzinger complex (preBötC). While we know the anatomical region …

Developing Iron Complexes For Electrocatalytic Hydrogen Generation, Benjamin Travis

Undergraduate Honors Theses

Artificial photosynthesis systems convert solar energy into chemical fuels such as hydrogen gas. Photocatalytic hydrogen generation systems have previously been developed, but reliance on expensive metal catalysts limits the viability of these systems. In order for artificial photosynthesis to be used as a large-scale clean energy solution, it is crucial to discover more active and cost-efficient catalysts.

To this end, several novel iron polypyridyl complexes were synthesized using relatively inexpensive reactants. Electrochemical testing revealed that these complexes are active electrocatalysts for the reduction of protons to generate hydrogen gas. Furthermore, a naphthalene-terminated iron polypyridyl complex was found to be an …

Welcoming The Game Changer Of Human Society: A Defense Of The Moral Permissibility And Obligations Of Human Genetic Engineering, Yongkang Li

Undergraduate Honors Theses

In 2018, a Chinese scientist, Jiankun He, announced the birth of two HIV-resistant babies through his experiment of human genetic engineering. This incidence has soon shocked the entire scientific community and invoked public outrage towards He’s corrupt moral integrity.

However, this event should also act as a harbinger to the human society that the technique of human genetic engineering is rapidly approaching maturity. In that case, how should we respond?

This thesis focuses on the moral issues surrounding human genetic engineering and advertises an accepting moral attitude to this booming technology. This thesis will first discuss the types of human …

Laurence Sterne: A Different Way Of Approaching The Notion Of Life In The Early Novel, Robert Metaxatos

Undergraduate Honors Theses

This thesis employs the later philosophy of Michel Foucault to think through the unique set of socio-cultural problems that emerged alongside the early novel. I endeavor to explain the development of “biopower” and the concomitant (yet historically grounded) concept of a mass population in order to round off a nettlesome tendency among historicist rise-of-the-novel critics to focus on the creation of a bourgeois individual at this time. To that end, the texts of Anglo-Irish author Laurence Sterne bear out a unique narratorial response to biopower that begins with the ‘body’ of his work: i.e., Shandeism. Signaling the importance of the …

The Battle Between Expertise And Misinformation To Influence Public Opinion: A Focus On The Anti-Vaccination Movement, Alexandra Bongiorno

Undergraduate Honors Theses

How do experts and anti-vaccination advocates effectively influence public opinion? This study examines the role of experts and non-experts in influencing public opinion. It uses the anti-vaccination movement as a case study to observe the antagonism between expert opinion and misinformation and how they are perceived by and influence the public. In particular, I examine the relationships between social media, misinformation, and expert opinion and how these relationships impact individuals to form their opinions. Additionally, I measure individual components such as science education background, ideology, and social media use to determine the effects of personal factors on opinion formation. I …

Message Reframing & Covid-19 Safety Precautions, Elise Coberly

Undergraduate Honors Theses

Past research found that the personality aspect Orderliness was more strongly associated with conservatism, while Compassion was more strongly associated with liberalism. The present research aimed to examine whether framing COVID-19 safety precautions (about mask wearing, social distancing, and vaccination) with an Orderliness or Compassion focus would make the message more receptive to liberals and conservatives. We hypothesized that reframing the messages to match with the participants’ personality and ideological leanings would lead to greater support for the message. In our study (N = 679), participants read a COVID-19 safety precaution message with either an Orderliness or Compassion frame …

The Role Of Spider Silk In Peripheral Nerve Regeneration, Langston Forbes-Jackson

Undergraduate Honors Theses

Spider silk neural guidance channels (NGCs) are highly important innovations in the field of regenerative medicine. This paper will discuss the evidence in the literature that supports their function in regenerative medicine and provide a template for future experiments in the field. While many studies within the past 15 years have demonstrated the validity of spider silk as a scaffold for peripheral nerve regeneration, the molecular mechanics that facilitate regeneration are poorly understood. An emphasis on using silk from orb weaving spiders in particular may have caused researchers to overlook other spiders whose silk could prove to have vastly different …

Physiological And Transcriptomic Analyses Of Inspiratory Rhythm- And Pattern- Generating Interneurons Of The Prebötzinger Complex In Mice, Prajkta Shashikant Kallurkar

Dissertations, Theses, and Masters Projects

Breathing is a vital rhythmic behavior essential for life. The preBötzinger complex (preBötC) of the lower brainstem houses a cluster of interneurons that generate the respiratory rhythm in humans and all terrestrial mammals. Neurons of the preBötC produce rhythmic bursts of neural activity that drive inspiration, the only inexorable active phase of the breathing cycle (expiration is normally passive). preBötC interneurons that comprise the core inspiratory rhythm generator are derived from precursors that express the transcription factor developing brain homeobox 1 (Dbx1). Neurons in the preBötC derived from Dbx1-expressing progenitors (hereafter referred to as Dbx1 preBötC neurons) produce rhythmic bursts …

Cellular And Synaptic Mechanisms That Underlie Eupnea And Sigh Rhythms For Breathing Behavior In Mice, Daniel Scott Borrus

Dissertations, Theses, and Masters Projects

Breathing is a lifelong activity that involves the coordination of several rhythmic behaviors. This dissertation investigates the neural origins of two of these breathing rhythms: eupnea and sighing. Eupnea, or regular unlabored breathing, occurs on the order of seconds and serves to drive the exchange of oxygen and carbon dioxide between the circulatory system and the environment. Sighs, deep breaths that are typically 2-5 times the volume of a eupneic breath, occur on the order of minutes and are critical in maintaining pulmonary function. Understanding how these rhythms are generated on a cellular and synaptic level is an essential step …

Examining Dual-Task Cognitive Processing From A Task-Set Perspective, Nicholas Surdel

Dissertations, Theses, and Masters Projects

Despite decades of empirical investigation, there remains active debate about the limitations to dual-task processing. The primary aim of the present research was to determine the roles of attentional and response-set components of task-set in dual-task processing. Through three experiments, we explored the relationships between attentional- and response-set switching in the context of a classic dual-task paradigm. Experiment I (N = 68) validated our novel integration of a dual-task task-switching paradigm. Experiment II (N = 64) replicated and extended Experiment I by integrating a single task subsection of the procedure. Finally, Experiment III (N = 23) integrated electroencephalographic measures of …

Gay Identity In Emerging Adulthood: Testing The Interaction Between Relational Satisfaction, Outness, And Gay Identity, Jeremy R. Goshorn

Dissertations, Theses, and Masters Projects

This work explored the ways in which the theoretical constructs of gay identity development, relational satisfaction, and outness interact in gay-male emerging adults. Informed by the literature on these constructs, the researcher developed a structural model to evaluate the interactive and mediating roles within the model. Three instruments were selected to assist in measuring these theoretical constructs. The Lesbian, Gay, and Bisexual Identity Scale (LGBIS) measured gay identity development, the Gay and Lesbian Relationship Satisfaction Scale (GLRSS) measured relational satisfaction, and the Nebraska Outness Scale (NOS) measured outness. A sample of 206 cisgender gay men in Emerging Adulthood (ages 19-29) …

The Effect Of Vaccination And Host Genetics On Transmission Dynamics Of Infectious Hematopoietic Necrosis Virus And Flavobacterium Psychrophilum In Rainbow Trout (Oncorhynchus Mykiss), Darbi Rae Jones

Dissertations, Theses, and Masters Projects

Globally, infectious diseases are responsible for major conservation and economic losses in wild and farmed fish populations. Prevention tools, including vaccination and breeding for genetic disease resistance, are used in many systems to prevent mortality by such diseases. Studies are often done to evaluate the efficacy of a preventative method at reducing disease, but the impact on transmission is rarely studied. Protection under diverse field conditions, such as variable pathogen exposure dosages, is also not fully understood. Furthermore, there is little information on how preventative methods alter host-pathogen relationships. For example, it is largely unknown how vaccination impacts non-target pathogens …

Posttraumatic Growth Of Young Adults Who Experienced A Parental Death During Adolescence: An Eriksonian Developmental Perspective, Victor Tuazon

Dissertations, Theses, and Masters Projects

Impacting millions of youth in the United States and across the globe, early parental death can be a very stressful and traumatic event and is an important topic to investigate. Utilizing an Eriksonian developmental perspective, this study (N = 256) examined a group of young adults who experienced a parental death during adolescence and a group of young adults who had not experienced an early parental death. The researcher examined the developmental impact of early parental death, and developed a predictive model of posttraumatic growth (PTG) for young adults who have experienced early parental death. When compared to non-bereaved peers, …

Salud Mental: The Conceptualization And Experiences Of Mental Health Among Undocumented Mexican Immigrants, Edith Gonzalez

Dissertations, Theses, and Masters Projects

This research study explored how undocumented immigrants define and experience mental health. A review of literature about undocumented Latinx immigrants emphasized that even in high distress, this population underutilizes mental health services. Data were analyzed through the lens of Latinx Critical Race Theory in an effort to conceptualize the role of multiple marginalization on the mental health state of undocumented Latinx immigrants. Eight undocumented Mexican immigrants in one city in a southern state were interviewed using semi-structured, open-ended questions. A transcendental phenomenology method was used to explore how this population experiences mental health. Data analysis revealed five themes that suggest …

Neuroanatomical And Morphological Properties Of Neurons That Generate Inspiratory Related Breathing Rhythm And Influence Respiratory Motor Pattern In Mice, Victoria Akins

Dissertations, Theses, and Masters Projects

The relationship between neuron morphology and function is a perennial issue in neuroscience. Information about synaptic integration, network connectivity, and the specific roles of neuronal subpopulations can be obtained through morphological analysis of key neurons within any given microcircuit. Breathing is essential behavior for humans and all mammals, yet the neural microcircuit that governs respiration is not completely understood. The respiratory neural microcircuit resides within the ventral respiratory column located in the medulla. Within the respiratory column, the site of respiratory rhythm generation is the bilaterally distributed preBötzinger complex (preBötC). Rhythm-generating neurons in the preBötC are derived from a single …

Role Of Dbx1-Derived Pre-Bötzinger Complex Interneurons In Breathing Behaviors Of Adult Mice, Nikolas C. Vann

Dissertations, Theses, and Masters Projects

Breathing is a rhythmic motor behavior essential to sustain homeostasis and life itself in humans and all terrestrial mammals. A specialized neuronal network is responsible for generating and controlling the rhythm and pattern for breathing. The core rhythm-generating microcircuit in particular is located within a site dubbed the preBötzinger complex (preBötC). The preBötC is a heterogeneous region containing neurons with both respiratory and non-respiratory activity that express excitatory and inhibitory transmitters, peptide transmitters and peptide receptors. More recently, preBötC neurons have been characterized by molecular genetics. The markers historically used to define the respiratory CPG within the preBötC intersect with …

Building A Consensus On The Professional Dispositions Of Counseling Students: A Content Analysis On Counseling Student Retention Policies, Jeffrey Kyle Christensen

Dissertations, Theses, and Masters Projects

No abstract provided.

In The "Spirit Of Investigation And Experiment": John Minson Galt Ii And Social Reform At The Eastern Asylum, Elise Aminta Salles

Dissertations, Theses, and Masters Projects

No abstract provided.

Assessing The Effects Of Workplace Aggression And Normative Unethical Behaviors On Counselors' Perceptions Of Ethicality Using An Integrative Understanding Of Morality, Eleni Maria Honderich

Dissertations, Theses, and Masters Projects

Acting ethically is a core facet of the counseling profession's identity, safeguarding clients from undue harm (ACA, 2005). Through an increased understanding of both detrimental and positive factors that can influence counselors' perceptions of ethical behaviors, the counseling profession can intervene accordingly; this knowledge may assist in managing the problem related to unethical infractions. However, ethical behavior is a multifaceted and complex phenomenon, leaving many factors to be explored and examined. Workplace aggression, exposure to normative unethical behaviors, and an integrated modal of morality constitute some of these factors that warrant further investigation. A dearth of research currently exists within …

Investigating Heat Shock Protein 70 As A Binding Partner Of Mk-Styx, And The Role Of Mk-Styx In Neuronal Differentiation, Lauren Elizabeth Rusnak

Dissertations, Theses, and Masters Projects

No abstract provided.