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Full-Text Articles in Medicine and Health Sciences
Mri Investigations Of Metabolic And Structural Brain Changes In Alzheimer’S Disease And Vitamin D Deprivation, Dickson Wong
Mri Investigations Of Metabolic And Structural Brain Changes In Alzheimer’S Disease And Vitamin D Deprivation, Dickson Wong
Electronic Thesis and Dissertation Repository
Alzheimer's disease (AD) is a neurodegenerative disorder of the brain that presents as progressive impairment across several cognitive domains. The biological mechanisms underlying the development of AD remain unclear, with amyloid-beta plaques, neurofibrillary tangles, calcium dysregulation, and oxidative stress all contributing to neurodegeneration in AD. Vitamin D (VitD) deficiency, a common condition in the elderly, may modulate these mechanisms and complicate the AD process. Due to this complicated pathogenesis, the diagnosis of AD requires subjective clinical judgement, staging of AD is challenging, and it remains difficult to predict when and who will progress to AD. The purpose of this thesis …
Identifying Neuroimaging And Genetic Correlates Of Delusions And Hallucinations In Alzheimer’S Disease, Juweiriya Ahmed
Identifying Neuroimaging And Genetic Correlates Of Delusions And Hallucinations In Alzheimer’S Disease, Juweiriya Ahmed
Electronic Thesis and Dissertation Repository
The co-occurrence of psychotic symptoms and Alzheimer’s disease (AD) is a devastating phenotype that affects around 50% of individuals with AD. We hypothesized that distinct interactions between brain structures and genetic variants in dopaminergic, cholinergic and glutamatergic neurotransmitter systems may be associated with the presence of hallucinations and delusions in AD. Using the Alzheimer’s Disease Neuroimaging Initiative, we identified participants that presented with symptoms of delusions, hallucinations, or both symptoms. PLS-CA was used to identify differences in patterns of interactions between 15 single nucleotide polymorphisms and 82 neuroanatomical regions of interest between AD patients endorsing symptoms of delusions, hallucinations, and …
Can Self-Efficacy Training Improve Memory And Functional Activation In Older Adults With Mild Cognitive Impairment? A Proof-Of-Concept Intervention Study, Brainscan, Western University, Lindsay Nagamatsu, Derek Mitchell, Paul Minda, Amer Burhan, Becky Horst
Can Self-Efficacy Training Improve Memory And Functional Activation In Older Adults With Mild Cognitive Impairment? A Proof-Of-Concept Intervention Study, Brainscan, Western University, Lindsay Nagamatsu, Derek Mitchell, Paul Minda, Amer Burhan, Becky Horst
Project Summaries
The goal of this study is to examine the changes in brain activity after a memory self-efficacy training program to better understand the mechanisms of memory self-efficacy. We will conduct a proof-of-concept six-week memory self-efficacy intervention in older adults with MCI, in order to demonstrate that self-efficacy impacts brain function. This will allow us to determine whether self-efficacy interventions may be a potential strategy for combating AD in the future.