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Follow-Up Study Evaluating The Long Term Outcome Of Chondromimetic In The Treatment Of Osteochondral Defects In The Knee, Agnes Berta, Matthew S. Shive, Andrew K. Lynn, Alan Getgood, Saara Totterman, Grahame Busby, Jerome Hollenstein, Gábor Vásárhelyi, Imre Kéki, László Hangody
Follow-Up Study Evaluating The Long Term Outcome Of Chondromimetic In The Treatment Of Osteochondral Defects In The Knee, Agnes Berta, Matthew S. Shive, Andrew K. Lynn, Alan Getgood, Saara Totterman, Grahame Busby, Jerome Hollenstein, Gábor Vásárhelyi, Imre Kéki, László Hangody
Bone and Joint Institute
© 2020 by the authors. Scaffolds are thought to be a key element needed for successful cartilage repair treatments, and this prospective extension study aimed to evaluate long-term structural and clinical outcomes following osteochondral defect treatment with a cell-free biphasic scaffold. Structural outcomes were assessed using quantitative 3-D magnetic resonance imaging (MRI) and morphological segmentation to determine the percentage of defect filling and repair cartilage T2 relaxation times, and clinical outcomes were determined with the modified Cincinnati Rating System, and the Knee Injury and Osteoarthritis Outcome Score (KOOS). Seventeen subjects with osteochondral defects in the knee were treated with ChondroMimetic …
Healing Of Osteochondral Defects Via Endochondral Ossification In An Ovine Model, Helen Lydon, Alan Getgood, Frances M.D. Henson
Healing Of Osteochondral Defects Via Endochondral Ossification In An Ovine Model, Helen Lydon, Alan Getgood, Frances M.D. Henson
Bone and Joint Institute
© The Author(s) 2017. Objective: The objective of this study was to describe the mechanism of healing of osteochondral defects of the distal femur in the sheep, a commonly used translational model. Information on the healing mechanism be useful to inform the design of tissue engineering devices for joint surface defect repair. Design: A retrospective study was conducted examining 7-mm diameter osteochondral defects made in the distal medial femoral condyle of 40 adult female sheep, comprising control animals from 3 separate structures. The healing of the defects was studied at post mortem at up to 26 weeks. Results: Osteochondral defects …