Medicine and Health Sciences Commons^™

Demographic And Psychosocial Factors Associated With Suicide Mortality Among Childbearing-Aged Individuals: A Case-Control Study, Katerina A. Furman, Amy Loree Phd, Lyuba Gavrilova Bs, Leah Hecht Phd, Hsueh-Han Yeh, Frances Lynch, Brian Ahmedani, Rebecca Rossom, Anne Beck Phd, Yihe Daida Phd, Gregory Simon Md, Christine Lu Phd, Joslyn Westphal Mph, Ashii Owen-Smith Phd, Stephen Waring, Cathrine Frank Md

Medical Student Research Symposium

Objective: Examine pregnancy-related, demographic, psychosocial and healthcare utilization factors associated with suicide mortality among childbearing-aged women. Methods: Data from nine health care systems in the Mental Health Research Network were included. A case-control study design was used in which 290 childbearing-age women who died by suicide (cases) from 2000-2015 were matched with 2,900 childbearing-age women from the same healthcare system and enrolled during the same time period who did not die by suicide. Conditional logistic regression was used to analyze associations between patient characteristics and suicide. Results: Women who died by suicide were more likely to have mental health or …

The Application Of Exercise Prescription Education In Medical Training, Thomas Sprys-Tellner, Diane L. Levine Md, Asim Kagzi

Medical Student Research Symposium

Objective: Physical inactivity is a significant contributor to many acute and chronic medical conditions. While the dangers of physical inactivity are well understood and physicians have a desire to address them, a lack of education in exercise prescription (ERx) may be a barrier to properly prescribing exercise to patients. The aim of this research was to explore the need for ERx education amongst students and physicians in training and determine the effectiveness of ER_x didactic.

Methods: A one hour curriculum was developed based on the American College of Sports Medicine principles of ERx. Pre- and post-surveys were administered immediately …

Differentiating Axonal From Demyelinating Neuropathies Using Multiparametric Quantitative Mri Of Peripheral Nerves, Jacob D. Baraz, Stephanie Xuan, Sadaf Saba, Xue Yang, Ryan Castoro, Yang Xuan, Alison Roth, Richard D. Dortch, Jun Li, Yongsheng Chen

Medical Student Research Symposium

Objectives: To develop a multiparametric quantitative MRI (qMRI) method to track pathological changes in the peripheral neuropathies.

Background: Irrespective of the causes or types of polyneuropathies, peripheral nerves are mainly afflicted by two kinds of pathologies – axonal loss and demyelination. It is critical to differentiate between the two as treatments are different for the two conditions. While nerve conduction studies (NCS) have been used to differentiate the two pathologies in the distal nerves, there are no tools to probe the pathologies in the proximal peripheral nerves. This is particularly needed when distal nerves become non-responsive in NCS.

Methods: We …

Medical Student Perceptions Comparing In-Person To Virtual Interviews In The Medical School Admissions Process, Iyanna Peppers, Sean Mccarthy, Abhinav Chinna Krishnan

Medical Student Research Symposium

Title: Medical Student Perceptions Comparing In-Person to Virtual Interviews in the Medical School Admissions Process

Background:

At Wayne State University School of Medicine (WSUSOM), prospective applicants are interviewed using three interview modalities: one faculty/alumni interview, one medical student interview, and five multiple-mini-interviews. Following COVID-19 induced institutional protocols, WSUSOM transitioned from in-person to a virtual format. In order to better understand how medical student interviewers viewed this transition, surveys were administered to those who experienced both in-person interviews (IPI) and virtual interviews (VI). The objective was to identify student perceptions of IPI and VI.

Methods:

This prospective, mixed …

Return To Play And Performance Following Anterior Cruciate Ligament Reconstruction In The National Women’S Soccer League, Varag Abed, Ajith Dupati, Gregory S. Hawk, Darren Johnson, Caitlin Conley, Austin V. Stone

Medical Student Research Symposium

Background: The anterior cruciate ligament (ACL) is a commonly injured ligament in athletes, usually requiring ACL reconstruction (ACLR).

Hypothesis/Purpose: To compare the return to play (RTP) and performance level of players following ACLR in the National Women’s Soccer League (NWSL). We hypothesized that there would be a high return to play rate following ACLR in the NWSL, but with a decrease in performance.

Methods: NWSL players that underwent ACLR were identified by cross-referencing multiple online resources that were identified between the 2013 and 2020 seasons. Players were classified into the following positions: forward, defender, midfielder, and goalkeeper. The following RTP …

Benzene Metabolite, Hydroquinone, Activates The Aryl Hydrocarbon Receptor Pathway In Trophoblasts, Darby P. Richards, Anthony Maxwell, Laura Stephan, Jiahui Ding, Gil Mor

Medical Student Research Symposium

Introduction: Benzene is the 6th most produced chemical in the world and a major pollutant that has been shown to have adverse effects on pregnancy. We previously showed that maternal benzene exposure during pregnancy induces maternal immune activation and also leads to an increase in fetal reabsorptions. The molecular mechanism in which benzene induces these negative effects is poorly understood. Here we developed a cellular model of benzene exposure to understand the molecular effect of benzene on trophoblast cells. Specifically, cells were exposed hydroquinone, a major benzene metabolite, in order to determine the molecular mechanism behind the observed maternal immune …

Worse Postoperative Outcomes And Higher Reoperation In Smokers Compared To Nonsmokers For Arthroscopic Rotator Cuff Repair, Susan G. Wager, Spencer Brown, Michael Gaudiani, Joshua P. Castle, Eric Jiang, Vasilios Moutzouros, Eric Makhni, Stephanie J. Muh

Medical Student Research Symposium

Introduction: Smoking impairs healing potential and is a significant risk factor for complications following orthopaedic surgeries. The purpose of this study was to determine if a cohort of former or current smokers at time of surgery met the minimally clinical important difference (MCID) for Patient-Reported Outcomes Measurement Information System Upper Extremity (PROMIS-UE), Depression (PROMIS-D), and Pain Interference (PROMIS-PI) scores in comparison to nonsmokers.

Methods: A retrospective review of patients who underwent rotator cuff repair was performed. Patients who completed preoperative and 6-month postoperative PROMIS scores were included. The MCID was calculated using a distribution technique with a threshold of 0.5 …

Group-Based Four-Dimensional Brain Mapping Of Executive Control, Matthew T. Brennan, Kazuki Sakakura Md, Masaki Sonoda Md, Phd, Aimee Luat Md, Neena Marupudi, Sandeep Sood Md, Eishi Asano Md, Phd

Medical Student Research Symposium

Rationale: Humans utilize executive control processes to carry out non-automatic tasks. These tasks require coordination from higher brain centers to both suppress inappropriate behaviors and initiate correct responses. The goal of this study is to generate a novel, dynamic brain atlas to visualize and understand the network dynamics underlying executive control.

Methods: We studied 547 non-epileptic intracranial electrode sites sampled from seven patients with focal epilepsy. Each patient performed two types of verbal tasks: word-reading and Stroop color-naming. Mixed model analysis compared high-gamma cortical activation prior to response onset between the word-reading and Stroop color-naming tasks. Based on mixed model …

The Top 50 Most Cited Articles On The Medial Patellofemoral Ligament (Mpfl): A Bibliometric Analysis, Varag Abed, Alex Duvall, Jonathan D. Rexroth, Alyssa Goodwin, Joseph Liu, Austin Stone

Medical Student Research Symposium

Objectives: To determine which original articles on the topic of the medial patellofemoral ligament (MPFL) have been cited the most in the literature utilizing a bibliometric approach. Secondarily, to determine temporal trends between article types.

Methods: Articles on the topic of the MPFL were identified by utilizing the Web of Science Database. The search yielded 1,596 results and the top 50 cited original articles were collected for further analysis. The following information was gathered for all included articles: title, first author's name, journal name, year of publication, impact factor of the journal in 2021, total number of citations of the …

Loss Of Connective Tissue Growth Factor Expression Promotes Remodeling Of The Extracellular Matrix And Epithelial-To-Mesenchymal Transition In Ovarian Cancer, Mc Harry Ramos, Sandra Galoforo, Colton Morris, Gil Mor, Ayesha Alvero, Radhika Gogoi

Medical Student Research Symposium

Background: Ovarian Cancer (OC) is the leading cause of death from gynecologic malignancies in the United States largely due to the advanced stage at the time of diagnosis. Epithelial-to-mesenchymal transition (EMT) is a key biological process implicated in the pathophysiology of the metastatic spread of OC. Discovering the “trigger/s,” its downstream targets, and therapeutic targeting are essential to substantively improve the survival of women with OC. The objective of our study is to evaluate the role of Connective Tissue Growth Factor (CTGF) in EMT in OC.

Methods: R182 and R2615 are well-described epithelial OC cell and MR182 and MR2615 are …

Gender Gap In Industry Payments To Urologists, Matthew Davis, Mohit Butaney, Alexandra Rogers, Taylor J. Malchow, Samantha Wilder, Alex Stephens, Sohrab Arora, Akshay Sood, Alexander Cole, Quoc-Dien Trinh, Craig Rogers, Firas Abdollah

Medical Student Research Symposium

Background: The Open Payments Program (OPP) was established in 2013 under the Sunshine Act, which mandated that medical device and pharmaceutical manufacturers submit public records of any financial incentive given to physicians. The study aim is to characterize the gap in general and research payments between male and female urologists over the past 7 years.

Methods: The study sample included all urologists in the US who received at least one general (GP) or research payment from 2015 to 2021. In order to identify urologists’ genders, the OPP was matched with the National Provider Index dataset. Payments to male …

Crohn’S Disease And Treatment In A Predominantly African American General Gi Clinic, Paul M. Kim, Angy Hanna, Jing Wang, Neel Patel, Maryam Haider, Bashar Mohamad, Paul Naylor, Milton Mutchnick

Medical Student Research Symposium

Given the high percentage of African Americans (AA) in our GI clinics and the paucity of AA focused studies on Crohn’s Disease (CD), we assessed racial disparity of the disease and its treatment in our predominately AA patient population. Patient records were examined to determine the accuracy of the CD diagnosis and to obtain relevant information for characterizing patients’ characteristics and treatments. In addition to race, patients were also categorized by GI visits to distinguish between patients under long term care (three or more visits) and those being seen to establish care (one or two visits). The 146 CD patients …

Comparing The Safety And Efficacy Of A Rapid High-Sensitivity Cardiac Troponin I Protocol Between Hospital-Based And Free-Standing Emergency Departments, Arqam Husain, Joseph B. Miller, Satheesh Gunaga, Seth Krupp, Howard Klausner, Elizabeth Plemmons, Hashem Nasseredine, Jacob Tuttle, Bernard Cook, James K. Mccord

Medical Student Research Symposium

Study Objectives: Current high sensitivity cardiac troponin I (hs-cTnI) research has been conducted almost exclusively in hospital-based emergency department (HBED) settings and the translation of these protocols into free-standing emergency departments (FSED) has yet to be explored. This study compared the safety and efficacy of applying a rapid-rule out protocol using hs-cTnI for exclusion of acute myocardial infarction (AMI) in HBEDs and FSEDs.

Methods: This was a secondary analysis of a randomized trial of patients evaluated for possible AMI in 9 emergency departments (ED) from July 2020 through March 2021. The trial arms included a new 0/1-hour rapid protocol using …

Failure To Treat Hcv In Patients Seen In A Predominately African American Socioeconomically Challenged Population, Crisshy Auguste, Paul H. Naylor Phd, Murray N. Ehrinpreis Md, Milton G. Mutchnik Md

Medical Student Research Symposium

The research objective of this proposal is to investigate the impediment with respect to moving a patient from initial antibody/PCR positive to successful completion of treatment. Secondary objectives include determining the most effective way for patients to progress from initial antibody/PCR positive to treatment and identifying the roadblocks for HCV antibody/PCR positive patients to be treated effectively.

Data was collected from 2019 HCV patient EMR charts, including demographics, laboratory studies, and treatment history. Concerning treatment, we evaluated linkage to the care; we defined success as treatment within six months of the initial visit. Thus, data on treatment initiation was collected …

Misinformation Regarding Monkeypox On Tiktok, Madison Meyer, Rajaa Shoukfeh, Dilara Turks, Geoffrey Potts

Medical Student Research Symposium

TikTok is the newest and most popular form of social media for young audiences around the world. Healthcare professionals can present medical information to all audiences in an engaging and short-length video manner. Our study evaluates the reliability of Monkeypox-related information presented on TikTok. We assessed the quality of the information presented using DISCERN, a peer-reviewed tool used for the evaluation of health information presented to consumers. Findings from our study suggest physicians, members of the healthcare field, and non-medical individuals post videos supplying viewers with information that is rated unreliable. Physicians and other healthcare professionals should prioritize providing reliable …

The Relationship Among Depression, Motivational Factors, And Diabetes Management In Emerging Adults With Type 1 Diabetes, Sahar Elmenini, April Idalski Carcone, Deborah Ellis

Medical Student Research Symposium

Self-determination theory (SDT) posits intrinsic motivation arises from fulfilling three psychological needs – autonomy, self-efficacy, and relatedness. SDT is useful for understanding the challenges emerging adults (EA, age 18-30) living with a chronic illness, like type 1 diabetes (T1D), face including developing independence, autonomy and new relationships while parental support and involvement decrease. This places EAs at risk for sub-optimal health. Depression can further decrease motivation. The aim of this study is to test the hypothesis that depressive symptoms are associated with motivation (autonomy and self-efficacy) which are associated with diabetes management (DM) in EAs with T1D. Participants (N=52) were …

The Effects Of Tert-Butyl Hydroquinone (Tbhq) On Estrogen Receptor Alpha (Erα) And Tumor Suppressor Protein P53 In T-47d And Mcf-7 Breast Cancer Cell Lines, Samantha E. Pfiffner, Katelyn Farrar, Erin Hallman, Kaylin Whittaker, Aisha Zanib, Sumi Dinda Ph.D.

Medical Student Research Symposium

Tert-butyl hydroquinone (TBHQ) is an aromatic compound that is commonly used as a preservative in processed food to prevent rancidity and lengthen shelf life. TBHQ is known to act as an antioxidant by protecting cells from radical oxygen species and thus preventing DNA damage. Although previous studies have found TBHQ to cause cancer cell death at high concentrations, they have also contrastingly found TBHQ, when studied in animal models, to enhance carcinogenic effects. However, the effect of TBHQ on breast cancer has not been thoroughly explored. With the prevalence of breast cancer and the wide use of TBHQ in processed …

Evaluation Of A Portable Gynecological Examination Table On Increasing Access To Cervical Cancer Screenings, Brennan Burrows, Giuliana Motta, Vibhasri Davuluri, Urvee Deo, Aman Tahir, Brindha Rajakumar, Jacob Blumenstein, Eliza Steinberg, Mariam Tobia, Asmita Tuladhar, Abigail Ahn

Medical Student Research Symposium

Introduction: Cervical cancer is a preventable disease affecting millions of women worldwide, with higher prevalence and mortality in developing countries. One explanation of this disparity is due to reduced access to screenings, especially in rural communities where mobile health clinics are limited by what medical equipment they can bring. To address these barriers, an engineering team called Project MESA (Making Examinations Safe and Accessible) designed a gynecological examination table that is portable, lightweight, and easily sanitizable.

Objective: This study aims to (1) evaluate whether the implementation of this device improves the clinician’s ability to perform pap smears as opposed to …

Surgical Management Of Velopharyngeal Dysfunction: Major Techniques And Trends For The 21st Century, Dominic Alessio-Bilowus, Sadaf Hashemian, Kylie Nikolli, Ahmed Hashem Md

Medical Student Research Symposium

INTRODUCTION: Surgical management of velopharyngeal dysfunction (VPD) has become increasingly complex over recent decades with advances in diagnosis, evaluation and technique, and research focus in this area is expected to shift accordingly. This study aims to educate readers on updates in management of VPD and explore changes in surgical methods through the 21st century.

METHODS: A systematic review was conducted of all literature published on surgical treatment of VPD since the year 2000, following PRISMA reporting guidelines. Adult-acquired VPD, any non-surgical management, implants and prosthetic devices, animal or cadaver models, and case series involving less than 10 subjects were excluded. …

Relative Contribution Of Different Upper Glycolytic Components In The Maintenance Of The Retinal Vascular Endothelial Cell Barrier, Nicole B. Oska, Ahmed S. Ibrahim, Mohamed Shawky, Diego Galarza Ramirez, Shaimaa Eltanani

Medical Student Research Symposium

Introduction: Damage to the retinal vascular endothelium is implicated in the progression of retinal degenerative diseases, including diabetic retinopathy (DR) and diabetic macular edema (DME). The retinal endothelial cells constitute the inner blood-retinal barrier (iBRB), and disruption of this barrier allows for the dysregulation of fluid and solute passage into the retina. Moreover, under normal physiological conditions, glycolytic metabolism is critical to the functioning of endothelial cells and maintenance of the iBRB. Conversely, in hyperglycemic environments, unregulated glycolytic metabolism leads to a buildup of glycolytic intermediates, which is thought to contribute to disruption of the iBRB and is associated with …

How Long Is Too Long?, Muhammad Ahmed, Sikander Chohan, Arqam Husain, Chelsea Meixner, Ujwal Patel, Benjamin Wright, Vijaya Kumar

Medical Student Research Symposium

Background: The United States is experiencing a nationwide shortage of nurses. Emergency departments (EDs) are at the forefront of this crisis which is contributing to long wait times for patients. Existing literature shows a strong correlation between increased wait times and patients leaving without being seen (LWBS). This likely increases the incidence of adverse events (AE).

Studies examining the impact of nursing coverage on the incidence of AE have been conducted primarily in inpatient settings. Our study aims to assess the relationship between nursing coverage and incidence of LWBS/AE in the ED.

Methods: This is a retrospective cohort study from …

Longitudinal Professional Identity Development Amongst Medical Students, Tala Al-Saghir, Mikaela Grudzien, Bridget Croniger, Margo Mekjian, Rachel Monconduit, Rubab Imtiaz, Alisha Williams, Sonja Klumpp, Jennifer Mendez

Medical Student Research Symposium

Abstract Title: Longitudinal Professional Identity Development Amongst Medical Students

Background:

Professional development is a core competency for medical student education. A standardized model for assessment of student longitudinal professional identity development will allow medical schools to better implement interventions.

Methods:

To assess professional development at a large, Midwest, allopathic medical school, a survey with seven statements regarding professional development was created. The statements encompassed domains of mentorship, communication skills, professionalism, and innovation and asked students to rank each statement from 1-5 (1 - highly deficient, 5 - highly proficient). The online, anonymous survey was emailed to all students (n = …

Learning Community Student-Resident Physician Mentorship, Kyla Kosidowski, Sahar Elmenini, Jack Considine, Madison Graifman, Dhruvil Patel, Megan Seyerle, Elise Turke, Kathleen Young, Nicole White, Chelsea Yu, Latoya Sherman, Eric Ayers Md

Medical Student Research Symposium

Wayne State University School of Medicine (WSUSOM) in 2018 formed Learning Communities (LCs), that facilitate student engagement, comradery, and mentoring. These programs include medical student-premed, near-peer, and faculty/attending mentorships. There has been an identified gap in mentorship between near-peer and faculty/attending mentorship, and that is near-peer mentors at WSUSOM have yet to complete the residency process to guide other students through it. Moreover, faculty/attending mentors are more removed from residency and may not have relevant advice for students. As resident physicians are recent graduates, they are more likely to provide relevant insight about residency applications, academic challenges, and efficiency than …

Central Corneal Thickness: A Retrospective Comparison Of Handheld Ultrasound Pachymetry And Optical Biometric Analysis Measurements, Hanna Simmons, Parker Williams, Jacob Diskin, Jacob Im, Kim Chaesik, Faisal Ridha Al-Timimi

Medical Student Research Symposium

Purpose

To determine if the measure of central cornea thickness among suspected and confirmed glaucomatous patients is significantly influenced by instrument device.

Methods

We retrospectively examined the charts of all patients having a central corneal thickness (CCT) measured with both ultrasound pachymetry and IOL Master 700 at the Kresge Eye Institute within the past year. Intraocular pressure and demographic data including age and race, were also collected. Significant corneal disease such as Fuchs corneal dystrophy, other corneal dystrophies, corneal transplant, and corneal edema were excluded. Statistical analysis of the paired CCT measurements were performed with a paired t-test and regression …

Childhood-Onset Attention-Deficit/Hyperactivity Disorder Exacerbates Opioid Use Disorder Consequences: Mediation By Impulsive Phenotypes, Liam R. Browning, Ciara Cannoy, Tabitha E. H. Moses, Leslie H. Lundahl Phd, David M. Ledgerwood Phd, Mark K. Greenwald Phd

Medical Student Research Symposium

Background: Attention deficit hyperactivity disorder (ADHD) is highly prevalent and associated with opioid use disorder (OUD). Yet, little is known about the mechanisms by which ADHD (which is a heterogeneous construct/diagnosis) might alter the trajectory of OUD outcomes.

Aim: This cross-sectional study examines relationships between childhood ADHD (inferred as predating substance use) and the extent to which the effects of ADHD on lifetime heroin-use consequences are mediated by foreshortened time perspective and drug-use impulsivity.

Methods: Individuals who report heroin use (N=214) were screened using the Assessment of Hyperactivity and Attention (AHA), Impulsive Relapse Questionnaire (IRQ), Stanford Time Perception Inventory (STPI), …

Professional Development Of Medical Students Transitioning From Preclinical To Clinical Training ​, Bridget Croniger, Mikaela Grudzien, Rubab Imtiaz, Jennifer Mendez

Medical Student Research Symposium

Background:

Personal and professional development (PPD) is a competency domain for graduated U.S. medical students. Current research shows that PPD is lowest at transitional periods, such as the transition from preclinical to clinical training.

Methods:

To assess professional development at a large, allopathic medical school, a survey with seven statements regarding professional development was formed. The statements encompassed domains of mentorship, communication skills, professionalism, team work, and innovation and asked students to rank each statement from 1-5 (1 - highly deficient, 5 - highly proficient). The online, anonymous survey was emailed to all second year medical students at Wayne State …

Glycine Is Dysregulated In Human Retinal Endothelial Cells And Proliferative Diabetic Retinopathy, Andrew Gregory, Shaimaa Eltanani, Thangal Yumnamcha, Mohamed Shawky, Bing Ross, Xihui Lin, Ahmed Ibrahim

Medical Student Research Symposium

Introduction: Diabetic retinopathy (DR) is a leading cause of blindness when it progresses to the proliferative diabetic retinopathy (PDR) stage. However, the alterations in amino acid (AA) profiles in PDR are largely unknown. In the present study, we aimed to characterize the AA profiles and identify the enriched pathways that are dysregulated commonly in both patients with PDR and human retinal endothelial cells (HRECs) subjected to the dual effect of high glucose (HG) and hypoxia, which are common risk factors associated with PDR.

Methods: HRECs were treated with osmotic control (Mannitol, 25 mM) or high glucose (HG, 25 mM) for …

Synergies Between Lactic And Acetic Acids In The Inhibition And Killing Of Strains Of Candida, Andrea Prenkocevic, Robert A. Akins

Medical Student Research Symposium

The most common vaginal diseases are bacterial vaginosis (BV) and vaginal candidiasis (VC), experienced by 29% and 75% of women, respectively. BV is characterized by a depletion of vaginal Lactobacillus species, displaced by dozens of BV-associated species; VC results from high abundance of Candida albicans or C. glabrata. It is not clear whether vaginal colonization or symptomatic infection by Candida is influenced by the vaginal microbiome and whether BV increases risk for VVC. Whether intravaginal Candida can flourish may depend on the major acids produced by Lactobacillus (lactate) versus non-Lactobacillus species in BV (acetate). The BV environment is typically pH …

Inhibitors Of Histone Deacetylase And Mcl-1 Synergistically Reduce Proliferation In Malignant Melanoma, Mehrnoosh Ghafouri, Chester Gauss, Yue Xi Phd, William Azkoul Ii Md, Abby Knudsen, Jordan Zuckerman, Sharon K. Michelhaugh Phd, Sandeep Mittal Md, Andrew M. Fribley Phd

Medical Student Research Symposium

Melanoma is a skin cancer that arises in melanocytes; it is the fifth most common cancer in the United States with approximately 100,000 new cases per year. Current treatments for malignant melanoma are surgical excision, radiation therapy and systemic therapy; however, the five-year survival rate for patients with stage IV is 29.8%. There is an urgent unmet clinical need to investigate novel treatments for these patients. Panobinostat is an orally available histone deacetylase inhibitor used in several hematologic malignancies, but it was ineffective as a single agent against melanoma in Phase 1. To address the insufficiency of options for melanoma …

Longitudinal Associations Between Dietary Fructose And Sodium And Systolic And Diastolic Blood Pressure Among Us Black And White Adults In The Cardia Study, Rana Elhamzawy, Dragana Komnenov, Daniel Domin

Medical Student Research Symposium

Longitudinal associations between dietary fructose and sodium and systolic and diastolic blood pressure among US Black and White adults in the CARDIA study

Authors: Rana Elhamzawy, Daniel Domin, Dragana Komnenov

Hypertension is one of the leading risk factors for major adverse cardiovascular events (MACE). Likewise, suboptimal dietary habits, including high fructose and sodium intake, are major contributors to mortality. High dietary fructose alone predisposes to salt-sensitivity of blood pressure, which is an independent, significant cardiovascular risk factor. We previously showed in our rat model of fructose-salt-sensitive hypertension that even a short term (4 weeks) feeding with 20% fructose and 4% …