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Virginia Commonwealth University
ALPHA THERAPY; MULTICENTER TRIAL; VIRAL-HEPATITIS; VIRUS-RNA; HCV RNA; NON-A; METAANALYSIS; MORTALITY; EFFICACY; DURATION
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Full-Text Articles in Medicine and Health Sciences
Interferon Alfa-2b Alone Or In Combination With Ribavirin As Initial Treatment For Chronic Hepatitis C, John G. Mchutchison , M.D., Stuart C. Gordon , M.D., Eugene R. Schiff , M.D., Mitchell L. Shiffman , M.D., William M. Lee , M.D., Vinod K. Rustgi , M.D., Zachary D. Goodman , M.D., Ph.D., Mei-Hsui Ling , Ph.D., Susannah Cort , M.D., Janice K. Albrecht , Ph.D.
Interferon Alfa-2b Alone Or In Combination With Ribavirin As Initial Treatment For Chronic Hepatitis C, John G. Mchutchison , M.D., Stuart C. Gordon , M.D., Eugene R. Schiff , M.D., Mitchell L. Shiffman , M.D., William M. Lee , M.D., Vinod K. Rustgi , M.D., Zachary D. Goodman , M.D., Ph.D., Mei-Hsui Ling , Ph.D., Susannah Cort , M.D., Janice K. Albrecht , Ph.D.
Internal Medicine Publications
BACKGROUND
Only 15 to 20 percent of patients with chronic hepatitis C have a sustained virologic response to interferon therapy. We compared the efficacy and safety of recombinant interferon alfa-2b alone with those of a combination of interferon alfa-2b and ribavirin for the initial treatment of patients with chronic hepatitis C.
METHODS
We randomly assigned 912 patients with chronic hepatitis C to receive standard-dose interferon alfa-2b alone or in combination with ribavirin (1000 or 1200 mg orally per day, depending on body weight) for 24 or 48 weeks. Efficacy was assessed by measurements of serum hepatitis C virus (HCV) RNA …