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Adam10 Exacerbation Of Allergic Disease Is Potentially Explained By Its Role In Cd23 Exosomal Sorting., Joel Mathews
Adam10 Exacerbation Of Allergic Disease Is Potentially Explained By Its Role In Cd23 Exosomal Sorting., Joel Mathews
Theses and Dissertations
CD23, the natural negative regulator of IgE, has been shown to be involved in asthma progression through its regulation of IgE. To investigate if its sheddase, ADAM10, is also involved in asthma progression, three mouse models were utilized; an IgE/mast cell dependent model, an IgE dependent, mast cell independent model and a mast cell and IgE independent model. Experimental asthma was then induced in mice which were selectively deficient for ADAM10 in B cells (ADAM10-/-) and compared to WT controls. The ADAM-/- mice had decreased signs of asthma, including eosinophilia, AHR and IgE synthesis in the IgE dependent model compared …