Medicine and Health Sciences Commons^™

Viloxazine In The Treatment Of Attention Deficit Hyperactivity Disorder, Amber N. Edinoff, Haseeb A. Akuly, John H. Wagner, Megan A. Boudreaux, Leah A. Kaplan, Shadman Yusuf, Elisa E. Neuchat, Elyse M. Cornett, Andrea G. Boyer, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in children. Over the past twenty years, research on the disease and its characteristics and treatment options has grown exponentially. The first-line pharmacologic treatment of ADHD is stimulants, which have a response rate of ~70%. With the support of four phase 3 studies involving more than 1,000 pediatric patients 6–17 years old, the FDA has approved the non-stimulant, serotonin-norepinephrine modulating agent (SNMA) viloxazine in an extended-release capsule (viloxazine ER) for treatment of ADHD in children aged 6–17. Viloxazine modulates serotonergic activity as a selective 5-HT22B receptor antagonist and 5-HT2C …

Similarities And Disparities Between Available Interventions For Ptsd In Veterans And The Formerly Incarcerated, James Mackey, Richard Oliva

MSW Capstone Conference

No abstract provided.

The Effects Of Covid-19 On Healthcare Professionals Mental Health: A Year Later, Eli Frank Mall, Britlyn Faith Neary

MSW Capstone Conference

No abstract provided.

African Americans With Type 1 And Type 2 Diabetes In San Joaquin County: Barriers Associated To Biases And Stereotypes In Diabetes Care, Leacha Clark, Alexis Jones

MSW Capstone Conference

No abstract provided.

Social Determinants Of Health That Bring People With Diabetes To The Emergency Department In Stockton, California, Ana Diaz-Garcia, Denise Mendez

MSW Capstone Conference

No abstract provided.

Master Of Social Work Capstone Projects: 2021: Executive Summary, University Of The Pacific

MSW Capstone Conference

Full program of the 2021 Master of Social Work Capstone Projects. See individual reports here: https://scholarlycommons.pacific.edu/msw-conference/

Chronic Illness And Rehospitalization: A Study Of Patients Experiencing Homelessness In Stockton, Sandra Leon, Marisela Cruz-Castro, Princess Nguyen

MSW Capstone Conference

No abstract provided.

Diabetes In The Workplace, Diana Madera Escobedo, Guadalupe Gomez, Sarah Vang

MSW Capstone Conference

No abstract provided.

Telehealth Services For Transgender Individuals, Cohen Price, Gina Girardi, Miguel Nazario

MSW Capstone Conference

This study looked into the positive and negative effects of telehealth services on the transgender community during the Covid- 19 pandemic. Via collaboration with the gender health. Center in Sacramento, five participants were interviewed utilizing a semi-structured questionnaire. Some of the major points that have been found in this study show that there are about an equal number of positive and negative effects telehealth and Covid- 19 has had on the transgender community. Interviewers noted that they were generally affected by the Covid- 19 pandemic which led to isolation and deterioration of their mental health. Some participants found the telehealth …

Shelter Seeker: A Vision To Connect Individuals Experiencing Housing Insecurities To Community Resources, Lex Acuna, Megan Asher, Jessica Carranza, Lexi Herman, Karinne Osumi, Karina Phan, Naima Reddick, Katie White

Occupational Therapy Student Research

Shelter Seeker is envisioned as a resource-based app and website that connects individuals experiencing housing insecurities to basic necessity services in Sacramento, CA. The ultimate goal is to improve accessibility to resources; listing them close to the user's location. This resource is envisioned to be available in multiple languages.

Assistive Technology: Foldable Shower Seat, Bernard Yaghobian, Katherine Enriquez, Dora Vang, Mitchell Johnston, Jennifer Luong, Yuen Ching Tam, Nupinder Kaur

Occupational Therapy Student Research

The goal of the foldable shower seat is to reduce the efforts required for showering, targeting individuals with circumstances that reduce their energy levels so they can reserve energy to carry out other meaningful activities.

Population:

• Older adults
• Individuals recovering from injuries
• Individuals with permanent disabilities

Wearable Technology For Fall Detection In The Rancho Yolo Community, Ashlyn Emberley, Brenda Fonseca, Carolina Mendiola, Hannah Gantuangco, Harleen Pabla, Janelle Candaza, Michelle Drawdy

Occupational Therapy Student Research

● Problem Statement: Community members have shared concern about leaving their home due to their fear of falling. This fear of falling decreases social, occupational, and community engagement.

● Category: Accommodations and Consumer Access, Priorities, and Benefits over the Lifespan

● Overview: Wearable assistive technology devices that assist in the incidence of falls to increase independence and promote engagement in a fulfilling life.

● Solution: Fall detection wearables provide medical help at the push of a button, including low and high technology devices for detection of falls.

Benzodiazepines: Uses, Dangers, And Clinical Considerations, Amber N. Edinoff, Catherine A. Nix, Janice W. Hollier, Caroline E. Sagrera, Blake M. Delacroix, Tunde Abubakar, Elyse M. Cornett, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Benzodiazepines (BZDs) are among one of the most widely prescribed drug classes in the United States. BZDs are a class of psychoactive drugs known for their depressant effect on the central nervous system (CNS). They quickly diffuse through the blood–brain barrier to affect the inhibitory neurotransmitter GABA and exert sedative effects. Related to their rapid onset and immediate symptom relief, BZDs are used for those struggling with sleep, anxiety, spasticity due to CNS pathology, muscle relaxation, and epilepsy. One of the debilitating side effects of BZDs is their addictive potential. The dependence on BZDs generally leads to withdrawal symptoms, requiring …

Catatonia: Clinical Overview Of The Diagnosis, Treatment, And Clinical Challenges, Amber N. Edinoff, Sarah E. Kaufman, Janice W. Hollier, Celina G. Virgen, Christian A. Karam, Garett W. Malone, Elyse M. Cornett, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Catatonia is a syndrome that has been associated with several mental illness disorders but that has also presented as a result of other medical conditions. Schizophrenia and other psychiatric disorders such as mania and depression are known to be associated with catatonia; however, several case reports have been published of certain medical conditions inducing catatonia, including hypo-natremia, cerebral venous sinus thrombosis, and liver transplantation. Neuroleptic Malignant Syndrome and anti-NMDA receptor encephalitis are also prominent causes of catatonia. Patients taking benzodiazepines or clozapine are also at risk of developing catatonia following the withdrawal of these medications—it is speculated that the prolonged …

Conolidine: A Novel Plant Extract For Chronic Pain, Amber N. Edinoff, Akash S. Patel, Mitchell W. Baker, Jesse Lawson, Christopher Wolcott, Elyse M. Cornett, Kambiz Sadegi, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Pain, the most common symptom reported among patients in the primary care setting, is complex to manage. Opioids are among the most potent analgesics agents for managing pain. Since the mid-1990s, the number of opioid prescriptions for the management of chronic non-cancer pain (CNCP) has increased by more than 400%, and this increased availability has significantly contributed to opioid diversion, overdose, tolerance, dependence, and addiction. Despite the questionable effectiveness of opioids in managing CNCP and their high rates of side effects, the absence of available alternative medications and their clinical limitations and slower onset of action has led to an …

Differential Involvement Of The Canonical And Noncanonical Inflammasomes In The Immune Response Against Infection By The Periodontal Bacteria Porphyromonas Gingivalis And Fusobacterium Nucleatum, Kívia Queiroz De Andrade, Cassio Luiz Coutinho Almeida-Da-Silva, David M. Ojcius, Robson Coutinho-Silva

All Dugoni School of Dentistry Faculty Articles

We examined the involvement of the P2 × 7 receptor and the canonical and noncanonical inflammasomes in the control of single-species or dual-species infection by the periodontal bacteria Porphyromonas gingivalis and Fusobacterium nucleatum in cells and mice. Stimulation of the P2 × 7 receptor leads to activation of the canonical NLRP3 inflammasome and activation of caspase-1, which leads to cleavage of pro-IL-1β to IL-1β, a key cytokine in the host inflammatory response in periodontal disease. The non-canonical inflammasome pathway involves caspase-11. Thus, wildtype (WT), P2 × 7^−/−, caspase-11^−/− and caspase-1/11^−/− mice were co-infected with both bacterial …

Online Learning During Covid-19 Produced Equivalent Or Better Student Course Performance As Compared With Pre-Pandemic: Empirical Evidence From A School-Wide Comparative Study, Meixun S. Zheng, Daniel Bender, Cindy Lyon

All Dugoni School of Dentistry Faculty Articles

Background: The COVID-19 pandemic forced dental schools to close their campuses and move didactic instruction online. The abrupt transition to online learning, however, has raised several issues that have not been resolved. While several studies have investigated dental students’ attitude towards online learning during the pandemic, mixed results have been reported. Additionally, little research has been conducted to identify and understand factors, especially pedagogical factors, that impacted students’ acceptance of online learning during campus closure. Furthermore, how online learning during the pandemic impacted students’ learning performance has not been empirically investigated. In March 2020, the dental school studied here moved …

Evaluation Of Usage-Induced Degradation Of Different Endodontic File Systems, Shekhar Bhatia, Venkateshbabu Nagendrababu, Ove A. Peters, Amr Fawzy, Umer Daood

All Dugoni School of Dentistry Faculty Articles

To evaluate structural profiles and mechanical behaviour of WaveOne Gold (WOG), Twisted File Adaptive (TFA) and XP-endo shaper (XPS) instruments after root canal preparation. Standardized in vitro shaping was performed in presence of 5.25% sodium hypochlorite. File morphology was analyzed using scanning electron microscopy; X-ray diffraction analysis was performed before and after use along with Raman spectroscopy. Nanoindentation was carried out to characterize surface topography. Ni2+ release was measured at 1, 3, 5 and 7 days. X-ray photoelectron spectroscopy (XPS) analysis was done before and after use. After allocating scan line shifts like in WOG, mechanical deformation was shown using …

“Now I Feel A Little Bit More Secure”: The Impact Of Snap Enrollment On Older Adult Ssi Recipients, Katie Savin, Alena Morales, Ronli Levi, Dora Alvarez, Hilary Seligman

All Faculty Scholarship

In June 2019, California expanded Supplemental Nutrition Assistance Program (SNAP) eligibility to Supplemental Security Income (SSI) beneficiaries for the first time. This research assesses the experience and impact of new SNAP enrollment among older adult SSI recipients, a population characterized by social and economic precarity. We conducted semi-structured, in-depth interviews with 20 SNAP participants to explore their experiences with new SNAP benefits. Following initial coding, member-check groups allowed for participants to provide feedback on preliminary data analysis. Findings demonstrate that SNAP enrollment improved participants’ access to nutritious foods of their choice, contributed to overall budgets, eased mental distress resulting from …

Author Correction To: Corticostriatal Functional Connectivity Of Bothersome Tinnitus In Single-Sided Deafness (Scientific Reports, (2019), 9, 1, (19552), 10.1038/S41598-019-56127-1), Jennifer Henderson-Sabes, Yingying Shang, Philip L. Perez, Jolie L. Chang, Seth E. Pross, Anne M. Findlay, Danielle Mizuiri, Leighton B. Hinkley, Srikantan S. Nagarajan, Steven W. Cheung

All Faculty Scholarship

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Contact Point Autumn 2021, Kara Sanchez

Contact Point

No abstract provided.

Insight - Fall 2021, Dugoni School Of Dentistry

Insight

Spotlighting the work of people at the Dugoni School, including clinical and biomedical research, the scholarship of teaching and learning, improvement of the health care system, professional partnerships that advance the field and more.

Interactions 2021, Thomas J. Long School Of Pharmacy And Health Sciences

Interactions

In each issue of Interactions, the School’s annual magazine you will find stories about students, faculty and alumni from each of our disciplines. Learn about the ways our students, faculty and alumni are impacting their communities through health care outreach. Read about their research and how they are contributing to advances in patient care. Meet our Alumni of the Year and get to know our faculty.

Pharmacologic And Clinical Considerations Of Nalmefene, A Long Duration Opioid Antagonist, In Opioid Overdose, Adam M. Kaye, Amber N. Edinoff, Catherine A. Nix, Tanner D. Reed, Elizabeth M. Bozner, Mark R. Alvarez, Mitchell C. Fuller, Fatimah Anwar, Elyse M. Cornett, Alan David Kaye

School of Pharmacy Faculty Articles

Opioid use disorder is a well-established and growing problem in the United States. It is responsible for both psychosocial and physical damage to the affected individuals with a significant mortality rate. Given both the medical and non-medical consequences of this epidemic, it is important to understand the current treatments and approaches to opioid use disorder and acute opioid overdose. Naloxone is a competitive mu-opioid receptor antagonist that is used for the reversal of opioid intoxication. When given intravenously, naloxone has an onset of action of approximately 2 min with a duration of action of 60–90 min. Related to its empirical …

Year In Review 2020-2021, Dugoni School Of Dentistry

Dugoni Academic Year in Review

Highlights of academic programs, clinical services, research, community outreach and other areas of University of the Pacific's Arthur A. Dugoni School of Dentistry.

The Influence Of Cbct-Derived 3d-Printed Models On Endodontic Microsurgical Treatment Planning And Confidence Of The Operator, Shreyas Oza, Johnah C. Galicia

Orthodontics and Endodontics Theses

Aims Use of 3D printed models in Endodontics has been gaining popularity since the technology to create them became more affordable. Currently, there are no studies that evaluate the influence of 3D models on endodontic surgical treatment planning and on operator confidence. Therefore, aims of this study were to: (i) Determine whether the availability of a 3D printed analogue can influence treatment-planning and operator confidence; and, (ii) Assess which factors of operator confidence are influenced, if any.

Materials and Methods Endodontists were asked to analyze a pre-selected CBCT scan of an endodontic surgical case and to answer a questionnaire that …

Paliperidone 3-Month Injection For Treatment Of Schizophrenia: A Narrative Review, Amber N. Edinoff, Prithvi K. Doppalapudi, Claudia V. Orellana, Caroline Ochoa, Shelby J. Patti, Yahya A. Ghaffar, Elyse M. Cornett, Aaron J. Kaye, Omar Viswanath, Ivan Urits, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Given the typical age onset of schizophrenia, there are tremendous economic and social impacts that extend beyond the person and their families. One critical determinant of the diseases' impact is the patient's adherence to antipsychotic drug treatment. Approved in 2015 for the treatment of schizophrenia, paliperidone palmitate (Invega Trinza, a 3-month injection, noted as PP3M) is a second-generation long-acting injectable antipsychotic medication. Among the different formulations offered for palmitate paliperidone, including the 1 and 3-month formulations, the longer duration 3-month formulation was better at preventing relapse in schizophrenic patients. To date, different formulations of palmitate paliperidone that have been studied …

Variants Of Facial Shape Genes In Patients With Class Ii Or Class I Malocclusion, Mahsa Mortazavi, Marie M. Tolarová Md, Phd, Drsc, Mirek Tolar

Orthodontics and Endodontics Theses

Background and purpose: In recent years, questions regarding the genetic and environmental factors affecting variation in human craniofacial morphology have received increasing attention. Medical and clinical genetic research using family studies has proven foundational for our understanding of which genes affect craniofacial variation. On the other hand, cephalometricbased studies showed a relationship between the cranial base and midface characteristics among individuals with different skeletal pattern of malocclusion. The purpose of our pilot study was to analyze specific variants of facial genes that were suggested to be associated with cranial base width and depth in Class II and Class I malocclusions. …

Variants Of Pax Gene Family In Patients With Class Ii Or Class I Malocclusion, Mana Naeim, Marie M. Tolarová Md, Phd, Drsc, Mirek Tolar

Orthodontics and Endodontics Theses

Background and Purpose. Orthodontic treatment helps to ensure proper function of teeth and to create healthy smiles. To this aim, the orthodontist’s goal is establishment of an esthetic harmony between soft and hard tissues of the face. Dimensions of facial width and height are crucial for accurate diagnosis and formulation of an efficient treatment plan. A knowledge of genetic determinants of these dimensions in Class II patients will deepen our understanding of etiology of skeletal Class II malocclusions and would make it possible to personalize a patient’s treatment plan. The purpose of our pilot study was to analyze, if specific …

Brexanolone, A GabaA Modulator, In The Treatment Of Postpartum Depression In Adults: A Comprehensive Review, Amber N. Edinoff, Amira S. Odisho, Kendall Lewis, Amir Kaskas, Grace Hunt, Elyse M. Cornett, Alan David Kaye, Adam M. Kaye, John Morgan, P. Scott Barrilleaux, David Lewis, Omar Viswanath, Ivan Urits

School of Pharmacy Faculty Articles

Postpartum depression (PPD) is one of the three major categories on the spectrum of postpartum psychiatric syndromes. Postpartum psychiatric syndromes are classified as either postpartum blues, postpartum depression, or postpartum psychosis. Postpartum depression is important to recognize clinically because of the effect it can have on the mother-child bond. The neurosteroid allopregnanolone, a progesterone derivative, is important for its role in positively modulating GABAA receptors. GABA-mediated signaling has been previously implicated in major depressive disorder. Allopregnanolone-mediated signaling has been identified as an important therapeutic target. Treatment with an allopregnanolone-analog, brexanolone, has been shown to improve depression scores in trials for …