Medicine and Health Sciences Commons^™

Effects Of Benzodiazepines, Antidepressants And Opioids On Driving: A Systematic Review And Meta-Analysis Of Epidemiological And Experimental Evidence, Tharaka L. Dassanayake, Patricia Michie, Gregory Carter, Alison L. Jones

Graduate School of Medicine - Papers (Archive)

Background: Many individuals in the community are prescribed psychoactive drugs with sedative effects. These drugs may affect their daily functions, of which automobile driving is a major component. Objective: To examine the association of three classes of commonly used psychoactive drugs (viz. benzodiazepines and newer non-benzodiazepine hypnotics, antidepressants and opioids) with (i) the risk of traffic accidents (as indexed by epidemiological indicators of risk); and (ii) driving performance (as indexed by experimental measures of driving performance). Methods: A literature search for material published in the English language between January 1966 and January 2010 in PubMed and EMBASE databases was combined …

Defining The Host Mucosal And Gut Microflora Interactions In Crohn's Disease Using Redundancy Analysis On Microarray Datasets, Caroline A. Kerr, J Shaw, Christopher S. Mcsweeney, Seungha Kang, M J. Buckley, T Lockett, Peter Pavlik

Graduate School of Medicine - Papers (Archive)

Introduction: Crohn’s disease (CD) is an inflammatory bowel disease that is characterised by chronic relapsing inflammation of the digestive tract. There is a significant body of evidence that suggests the intestinal mucosal microbiome interacts with the immune response to produce pathological inflammation and together these factors play a major role in the pathogenesis of CD. The aim of this study is to investigate interactions between the human intestinal mucosal transcriptome and mucosal microbiome using multivariate redundancy analysis on microarray datasets.

Methods: DNA and RNA were extracted from the same mucosal biopsies collected from CD patients (terminal ileum: n=5 from sites …

A Psychometric Analysis Of The Mental Health Consumer Participation Questionnaire, Brenda Happell, Lorna Moxham, Chris Platania-Phung

Faculty of Health and Behavioural Sciences - Papers (Archive)

If consumer participation is to be translated from rhetoric into reality, the attitudes of health professionals need to be addressed. Educational strategies can play an important role, but measures of attitudes are needed to determine the effectiveness of these strategies. This paper seeks to establish the Mental Health Consumer Participation Questionnaire (MHCPQ) on psychometric grounds, and explore attitude levels. Overall, the 150 nursing students who participated saw consumer participation in a favourable light, although this varied with the nature and extent of involvement. Psychometric properties, attitude structure, and attitude differences are reported. The MHCPQ displays good face validity and can …

Toward Consensus In The Analysis Of Urinary 8-Oxo-7,8-Dihydro-2′- Deoxyguanosine As A Noninvasive Biomarker Of Oxidative Stress, M D Evans, R Olinski, S Loft, M S Cooke, Jr P Rossner, R Sram, T Henriksen, H E Poulsen, Allan Weimann, A Barbieri, L Sabatini, F Violante, S Kino, T Ochi, K Sakai, M Takeuchi, H Kasai, J H N Meerman, D Gackowski, R Rozalski, A Siomek, Barry Halliwell, Andrew M. Jenner, H Wang, C Cerda, G Saez, S Haghdoost, P Svoboda, C-W Hu, M-R Chao, K-Y Peng, W-C Shih, K-Y Wu, H Orhan, N S Istanbullu, V Mistry, P B Farmer, J Sandhu, R Singh, C Cortez, Y Su, R M Santella, P Lambert, R Smith

Illawarra Health and Medical Research Institute

Of the DNA-derived biomarkers of oxidative stress, urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is the most frequently measured. However, there is significant discrepancy between chromatographic and immunoassay approaches, and intratechnique agreement among all available chromatography-based assays and ELISAs is yet to be established. This is a significant obstacle to their use in large molecular epidemiological studies. To evaluate the accuracy of intra/intertechnique and interlaboratory measurements, samples of phosphate buffered saline and urine, spiked with different concentrations of 8-oxoG, together with a series of urine samples from healthy individuals were distributed to ESCULA members. All laboratories received identical samples, including 2 negative controls that …