Medicine and Health Sciences Commons^™

Antarctic Moss Biflavonoids Show High Antioxidant And Ultraviolet-Screening Activity, Melinda J. Waterman, Ari Satia Nugraha, Rudi Hendra, Graham E Ball, Sharon A. Robinson, Paul A. Keller

Faculty of Science, Medicine and Health - Papers: part A

Ceratodon purpureus is a cosmopolitan moss that survives some of the harshest places on Earth: from frozen Antarctica to hot South Australian deserts. In a study on the survival mechanisms of the species, nine compounds were isolated from Australian and Antarctic C. purpureus. This included five biflavonoids, with complete structural elucidation of 1 and 2 reported here for the first time, as well as an additional four known phenolic compounds. Dispersion-corrected DFT calculations suggested a rotational barrier, leading to atropisomerism, resulting in the presence of diastereomers for compound 2. All isolates absorbed strongly in the ultraviolet (UV) spectrum, e.g., biflavone …

Cereal Fibre Intake In Australia: A Cross Sectional Analysis Of The 2011-12 National Nutrition And Physical Activity Survey, Eden Barrett, Yasmine Probst, Eleanor J. Beck

Faculty of Science, Medicine and Health - Papers: part A

Extensive evidence supports health benefits of cereal fibre, however globally no national intake data exists. This study aimed to determine estimates of intake and food sources of cereal fibre, and relationships to dietary fibre intake in an Australian sample population. A cereal fibre database was applied to dietary intake data from the 2011-12 National Nutrition and Physical Activity Survey (n ¼ 12,153). Usual intake based on 2-day intake data was weighted to infer population results. Median daily cereal fibre intake was 6.4 g/d (9.7 g/10 MJ/d) for adults (19-85 years) and 6.2 g/d (10.2 g/10 MJ/d) for children/adolescents (2-18 years). …

Functional Amyloid Protection In The Eye Lens: Retention Of Α-Crystallin Molecular Chaperone Activity After Modification Into Amyloid Fibrils, Megan Garvey, Heath Ecroyd, Nicholas J. Ray, Juliet A. Gerrard, John A. Carver

Illawarra Health and Medical Research Institute

Amyloid fibril formation occurs from a wide range of peptides and proteins and is typically associated with a loss of protein function and/or a gain of toxic function, as the native structure of the protein undergoes major alteration to form a cross β-sheet array. It is now well recognised that some amyloid fibrils have a biological function, which has led to increased interest in the potential that these so-called functional amyloids may either retain the function of the native protein, or gain function upon adopting a fibrillar structure. Herein, we investigate the molecular chaperone ability of α-crystallin, the predominant eye …

Muscle Sympathetic Nerve Activity Is Associated With Liver Insulin Sensitivity In Obese Non-Diabetic Men, Daniel L.T Chen, Rachael Brown, Carsten Liess, Anne Poljak, Aimin Xu, Jialiang Zhang, Michael Trenell, Arthur Jenkins, Donald B. Chisholm, Dorit Samocha-Bonet, Vaughan G. Macefield, Jerry R. Greenfield

Faculty of Science, Medicine and Health - Papers: part A

Introduction: Muscle sympathetic nerve activity (MSNA) may play a role in insulin resistance in obesity. However, the direction and nature of the relationship between MSNA and insulin resistance in obesity remain unclear. We hypothesized that resting MSNA would correlate inversely with both muscle and liver insulin sensitivity and that it would be higher in insulin-resistant vs. insulin-sensitive subjects.

Materials and methods: Forty-five non-diabetic obese subjects were studied. As no significant relationships were found in women, the data presented in on 22 men aged 48 ± 12 years. Two-step (15 and 80 mU/m2/min) hyperinsulinaemic-euglycaemic clamps were performed using deuterated …