Medicine and Health Sciences Commons^™

Airway Epithelial Innate Immunity, Sebastian L. Johnston, David L. Goldblatt, Scott E. Evans, Michael J. Tuvim, Burton F. Dickey

School of Medicine Publications and Presentations

Besides providing an essential protective barrier, airway epithelial cells directly sense pathogens and respond defensively. This is a frontline component of the innate immune system with specificity for different pathogen classes. It occurs in the context of numerous interactions with leukocytes, but here we focus on intrinsic epithelial mechanisms. Type 1 immune responses are directed primarily at intracellular pathogens, particularly viruses. Prominent stimuli include microbial nucleic acids and interferons released from neighboring epithelial cells. Epithelial responses revolve around changes in the expression of interferon-sensitive genes (ISGs) that interfere with viral replication, as well as the further induction of interferons that …

In Silico Cd4+, Cd8+ & Humoral Immunity Associated Antigenic Epitope Prediction And Hla Distribution Analysis Of Htlv-I, Tasneem Bano, Essam Mohammed Janahi, Anupam Dhasmana, Mohtashim Lohani, Shafiul Haque, Raju K. Mandel, Sajad A. Dar, Arshad Jawed, Mohd Wahid, Naseem Akhter, Mohammaed Y. Areeshi

School of Medicine Publications and Presentations

Purpose: The linkage of human T-cell leukemia virus type 1 (HTLV-1) to fatal diseases is a well known fact for many years. However, there has been no significant progress in the field of the treatment that can lead to the development of a successful vaccine. Furthermore, there are no means of assessing the risk of disease and its prognosis in the infected people.

Methods:The current study has taken the cognizance of the importance of host’s immune response in reducing the risk of infectious diseases to carry out immunoinformatics driven epitope screening strategy of vaccine candidates against HTLV-1. In this …