Medicine and Health Sciences Commons^™

Covid-19 And Chronic Diabetes: The Perfect Storm For Reactivation Tuberculosis?: A Case Series, Genesis P. Aguillón-Durán, Ericka Prieto-Martinez Dr, Doris Ayala, Juan García Jr., John M. Thomas Iii, Juan Ignacio García, Brandon Michael Henry, Jordi B. Torrelles, Joanne Turner, Eder Ledezma-Campos, Blanca I. Restrepo

School of Medicine Publications and Presentations

Background

The coronavirus disease 2019 pandemic is predicted to have a net negative effect on tuberculosis control, with an estimated excess of 6.3 million tuberculosis cases and 1.4 million deaths by 2025. Programmatic issues such as the lockdown of tuberculosis services affect all patients, while biosocial factors have a differential impact on an individual’s risk for tuberculosis or adverse tuberculosis outcomes.

Case presentation

We report three Hispanic cases of incident tuberculosis (two males, 43 and 44 years old; one female, 49 years old) after resolution of coronavirus disease episodes. Coincidentally, all cases shared a common risk factor: a chronic history …

Efficacy And Safety Of Covid-19 Convalescent Plasma In Hospitalized Patients: A Randomized Clinical Trial, Mila B. Ortigoza, Hyunah Yoon, Keith S. Goldfeld, Andrea B. Troxel, Johanna P. Daily, Yinxiang Wu, Yi Li, Danni Wu, Gia F. Cobb, Andrew N. Dentino

School of Medicine Publications and Presentations

Importance: There is clinical equipoise for COVID-19 convalescent plasma (CCP) use in patients hospitalized with COVID-19.

Objective: To determine the safety and efficacy of CCP compared with placebo in hospitalized patients with COVID-19 receiving noninvasive supplemental oxygen.

Design, setting, and participants: CONTAIN COVID-19, a randomized, double-blind, placebo-controlled trial of CCP in hospitalized adults with COVID-19, was conducted at 21 US hospitals from April 17, 2020, to March 15, 2021. The trial enrolled 941 participants who were hospitalized for 3 or less days or presented 7 or less days after symptom onset and required noninvasive oxygen supplementation.

Interventions: A unit of …

A Statistical Comparison Of Covid-19 In The United States Across Political Affiliations And Census Regions, Margarito Torres

Theses and Dissertations

In mid-January 2020, the United States reported their first cases of the coronavirus disease (COVID-19) from a passenger returning from Wuhan, China. Initially, the situation wasn’t very alarming as in China and European countries, but the situation began to worsen in March 2020 when the number of cases began to multiply. Then, in a matter of a few months, the United States became the number one country in terms of total cases and total deaths from COVID-19. We have been closely observing the United States and the world since July 2020. Our study aims to compare the political affiliations and …

College Students’ Well-Being During The Covid-19 Pandemic: A Systematic Review Of The Literature, Michaela Q. Iglesia, Ming-Tsan Lu

School of Medicine Publications and Presentations

Studies have shown increased levels of distress during the coronavirus disease-19 (COVID-19) pandemic, and college students are becoming more recognized as a vulnerable population. This narrative systematic review aims to synthesize the current understanding of mental health, lifestyle, and socioeconomic impacts that the pandemic had on college students in the United States. A search was conducted on PubMed, PsycInfo, and Web of Science. A total of 34 observational studies were included which examined aspects of college students’ health and experiences during the COVID-19 pandemic in the United States. A great deal of students was shown to experience a moderate level …

Drug-Based Therapeutic Strategies For Covid-19-Infected Patients And Their Challenges, Khatereh Zarkesh, Elaheh Entezar-Almahdi, Parisa Ghasemiyeh, Mohsen Akbarian, Marzieh Bahmani, Shahrzad Roudaki, Rahil Fazlinejad, Soliman Mohammadi-Samani, Negar Firouzabadi, Majid Hosseini, Fatemeh Farjadian

Manufacturing & Industrial Engineering Faculty Publications and Presentations

Emerging epidemic-prone diseases have introduced numerous health and economic challenges in recent years. Given current knowledge of COVID-19, herd immunity through vaccines alone is unlikely. In addition, vaccination of the global population is an ongoing challenge. Besides, the questions regarding the prevalence and the timing of immunization are still under investigation. Therefore, medical treatment remains essential in the management of COVID-19. Herein, recent advances from beginning observations of COVID-19 outbreak to an understanding of the essential factors contributing to the spread and transmission of COVID-19 and its treatment are reviewed. Furthermore, an in-depth discussion on the epidemiological aspects, clinical symptoms …

Evaluation Of The United States Covid-19 Vaccine Allocation Strategy, Md Rafiul Islam, Tamer Oraby, Audrey Mccombs, Mohammad Mihrab Chowdhury, Mohammad Al-Mamun, Michael G. Tyshenko, Claus Kadelkai

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

Background: Anticipating an initial shortage of vaccines for COVID-19, the Centers for Disease Control (CDC) in the United States developed priority vaccine allocations for specific demographic groups in the population. This study evaluates the performance of the CDC vaccine allocation strategy with respect to multiple potentially competing vaccination goals (minimizing mortality, cases, infections, and years of life lost (YLL)), under the same framework as the CDC allocation: four priority vaccination groups and population demographics stratified by age, comorbidities, occupation and living condition (congested or non-congested).

Methods and findings: We developed a compartmental disease model that incorporates key elements of the …

Impact Of Covid-19 On Otolaryngology Literature, Yeshwant R. Chillakuru, Eleanor F. Gerhard, Timothy Shim, Samuel H. Selesnick, Lawrence R. Lustig, John H. Krouse, Ehab Y. Hanna, Timothy L. Smith, Edward W. Fisher, Joseph E. Kerschner, Ashkan Monfared

School of Medicine Publications and Presentations

Objective

To understand the effect of the COVID-19 pandemic on the volume, quality, and impact of otolaryngology publications.

Methods

Fifteen of the top peer-reviewed otolaryngology journals were queried on PubMed for COVID and non-COVID related articles from April 1, 2020 - March 31, 2021 (pandemic period) and pre-COVID articles from the year prior. Information on total number of submissions and rate of acceptance were collected from seven top-ranked journals.

Results

Our PubMed query returned 759 COVID articles, 4885 non-COVID articles, and 4200 pre-COVID articles, corresponding to a 34% increase in ENT publications during the pandemic period. Meta-analysis/reviews and miscellaneous publication …

A Case Report Of A Patient On Therapeutic Warfarin Who Died Of Covid-19 Infection With A Sudden Rise In D-Dimer, Reita N. Agarwal, Hersheth Aggarwal, Ashmit Verma, Manish Tripathi

School of Medicine Publications and Presentations

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has disrupted social and economic life globally. The global pandemic COVID-19 caused by this novel SARS-CoV-2 shows variable clinical manifestations, complicated further by cytokine storm, co-infections, and coagulopathy, leading to severe cases and death. Thrombotic complications arise due to complex and unique interplay between coronaviruses and host cells, inflammatory response, and the coagulation system. Heparin and derivatives are World Health Organization (WHO) recommended anticoagulants for moderate and severe Corona Virus Disease 19 (COVID-19), that can also inhibit viral adhesion to the cell membrane by interfering with heparan sulfate-dependent binding to angiotensin-converting enzyme …

Implications Of Helminth Immunomodulation On Covid-19 Co-Infections, Nathalie Chacon, Leonor Chacin-Bonilla, Italo M. Cesar

School of Medicine Publications and Presentations

Coronavirus disease 2019 (COVID-19) and helminths infections can be in a synergistic epidemic in developing and suburban areas of industrialized countries. The coinfected hosts will derive a parasite-specific Th2 innate and adaptive immune response with CD4+ T cells, eosinophils, interleukin-4, interleukin-5, and interleukin-10. In the early stages of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, virus-specific Th1 cytotoxic CD8+ T cell, interleukin-6, interferon-γ, and interleukin-27 by lung are keys in controlling viral replication in the lung epithelial cells and limiting the pathology to other organs, like the intestine. CD4+ and CD8+ T cells are associated with protective immunity …

Endothelial Senescence And Chronic Fatigue Syndrome, A Covid-19 Based Hypothesis, Adonis Sfera, Carolina Osorio, Carlos M. Zapata Martín Del Campo, Shaniah Pereida, Jose Campo Maldonado, Zisis Kozlakidis

School of Medicine Publications and Presentations

Myalgic encephalomyelitis/chronic fatigue syndrome is a serious illness of unknown etiology, characterized by debilitating exhaustion, memory impairment, pain and sleep abnormalities. Viral infections are believed to initiate the pathogenesis of this syndrome although the definite proof remains elusive. With the unfolding of COVID-19 pandemic, the interest in this condition has resurfaced as excessive tiredness, a major complaint of patients infected with the SARS-CoV-2 virus, often lingers for a long time, resulting in disability, and poor life quality. In a previous article, we hypothesized that COVID-19-upregulated angiotensin II triggered premature endothelial cell senescence, disrupting the intestinal and blood brain barriers. Here, …

End Of Life Decision-Making Challenges In A Latino Patient With Covid-19: Facing Barriers, Irma Huayanay, Celia Pantoja, Chelsea Chang

School of Medicine Publications and Presentations

COVID-19 pandemic brought difficult scenarios that patients and families are facing about end- of-life decisions. This exposed some weak areas in the healthcare system where we can continue improve in reducing disparities and emphasizing advance care planning from a primary level of care. We present a case of challenges in end-of-life decision-making in a Latino patient.

Emerging Issues In Covid-19 Vaccination In Tropical Areas: Impact Of The Immune Response Against Helminths In Endemic Areas, Leonor Chacin-Bonilla, Nathalie Chacón-Fonseca, Alfonso J. Rodriguez-Morales

School of Medicine Publications and Presentations

The Coronavirus Disease 2019 (COVID-19) pandemic has affected over 165 million people and caused the death of 3.4 million worldwide (up to May 20, 2021) (https://coronavirus.jhu.edu/map.html), becoming a serious problem of global public health and the worst epidemic in the last century, after the pandemic 1918 influenza. Researchers worldwide are trying to find valuable drugs against the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). Some of them focused as antivirals, others targeted in other ways (e.g. immunomodulation) to relieve the symptoms of the infected patients and help lower the death toll throughout the world. Unfortunately, there is a lack of …

Covid-19 Student Mental Health Check Ii, Dianna Blankenship, Irma S. Jones

Criminal Justice Faculty Publications and Presentations

The year 2020 will forever be known as the year of the COVID-19 pandemic which has affected the entire population in one way or another. What began in January 2020 still has the world population firmly in its grip a year later. The students’ responses, in their own words, to changes in living, daily `routines, and health fears can be seen in the following paper. In this article, the responses of students in several undergraduate classes at a Hispanic serving institution in south Texas were collected and synthesized. The 155 responses were divided into seven frequently observed and repeated themes: …

Media Framing, Moral Panic And Covid-19: A Comparative Analysis Of China, South Korea, And The Us., Deena Devore, Sinyong Choi, Yudu Li, Hong Lu

Criminal Justice Faculty Publications and Presentations

COVID-19 is perhaps the single most impactful event defining 2020 globally. Drawing on theory on media typology involving freedom and responsibility, media framing and moral panic theories, this paper examines media coverage on COVID-19 in three countries, China, South Korea and the United States. Data were obtained from six news outlets, Xinhua News, South China Morning Post, Chosun, Hankyoreh, CNN and Breitbart, two from each of the three countries. More than 1,000 COVID-19 related reports, spanning six days (the last day of January to June, 2020) were selected and coded based on common priming themes such as tone, the othering, …

Social Distancing And Testing As Optimal Strategies Against The Spread Of Covid-19 In The Rio Grande Valley Of Texas, Kristina P. Vatcheva, Josef A. Sifuentes, Tamer Oraby, Jose Campo Maldonado, Timothy Huber, Cristina Villalobos

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

At the beginning of August 2020, the Rio Grande Valley (RGV) of Texas experienced a rapid increase of coronavirus disease 2019 (abbreviated as COVID-19) cases and deaths. This study aims to determine the optimal levels of effective social distancing and testing to slow the virus spread at the outset of the pandemic. We use an age-stratified eight compartment epidemiological model to depict COVID-19 transmission in the community and within households. With a simulated 120-day outbreak period data we obtain a post 180-days period optimal control strategy solution. Our results show that easing social distancing between adults by the end of …

Application Of An Evidence-Based, Out-Patient Treatment Strategy For Covid-19: Multidisciplinary Medical Practice Principles To Prevent Severe Disease☆, Elliot M. Frohman, Nicole R. Villemarette-Pittman, Adriana Rodriguez, Robert Glanzman, Sarah Rugheimer, Oleg Komogortsev, Scott S. Zamvil, Roberto A. Cruz, Thomas C. Varkey, Ashley N. Frohman

School of Medicine Publications and Presentations

The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to hitch a ride on our global transportation systems, means that we are will likely continue to confront an invisible, yet devastating foe. The enemy targets one of …

Significant Stakeholders: Toward An Agile Knowledge Management System In The Time Of Coronavirus Crisis, Yaojie Li, Yi Zhou, Thomas Stafford, Xuan Wang

Information Systems Faculty Publications and Presentations

Effective crisis response requires sophisticated knowledge management in organizations. Agile systems development capabilities for such crisis response systems are important, particularly for purposes of tailoring a crisis-oriented knowledge management system to a rapidly shifting threat landscape. We propose an architecture for achieving both of these ends in the form of an Agile Crisis Management System involving three specific stakeholders, and we discuss the steps, outcomes, and implications of such a system.

Sars-Cov-2: Potencial Transmisión Feco-Oral E Implicaciones En La Propagación Y Gravedad Del Covid-19 En Venezuela. Mini-Revisión. [Sars-Cov-2: Potential Feco-Oral Transmission And Implications On The Spread And Severity Of Covid-19 In Venezuela. Mini-Review.], Leonor Chacin-Bonilla, Nathalie Chacon

School of Medicine Publications and Presentations

The recognized human-to-human transmission of SARS-CoV-2 is through respiratory droplets and contact with contaminated surfaces. However, the high transmissibility of the virus and the pattern of symptoms of COVID-19 suggest the likelihood of other forms of spread. Increasing evidence suggests that SARS‐CoV‐2 could be transmitted by the feco‐oral route. SARS-CoV-2 is known to infect gastrointestinal epithelial cells and a significant number of infected people have gastrointestinal symptoms. Viable viruses, viral RNA, and prolonged shedding of viral RNA have been detected in the feces of COVID-19 patients. The virus has been found in sewage and surface waters of several countries. The …

Modeling The Effect Of Lockdown Timing As A Covid‑19 Control Measure In Countries With Differing Social Contacts, Tamer Oraby, Michael G. Tyshenko, Jose Campo Maldonado, Kristina Vatcheva, Susie Elsaadany, Walid Q. Alali, Joseph C. Longenecker, Mustafa Al‑Zoughool

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

The application, timing, and duration of lockdown strategies during a pandemic remain poorly quantified with regards to expected public health outcomes. Previous projection models have reached conflicting conclusions about the effect of complete lockdowns on COVID-19 outcomes. We developed a stochastic continuous-time Markov chain (CTMC) model with eight states including the environment (SEAMHQRD-V), and derived a formula for the basic reproduction number, R0, for that model. Applying the R 0 formula as a function in previously-published social contact matrices from 152 countries, we produced the distribution and four categories of possible R 0 for the 152 countries and chose one …

Endovascular Thrombectomy Time Metrics In The Era Of Covid-19: Observations From The Society Of Vascular And Interventional Neurology Multicenter Collaboration, Alexandra L. Czap, Alicia M. Zha, Jacob Sebaugh, Ameer E. Hassan

School of Medicine Publications and Presentations

Background Unprecedented workflow shifts during the coronavirus disease 2019 (COVID-19) pandemic have contributed to delays in acute care delivery, but whether it adversely affected endovascular thrombectomy metrics in acute large vessel occlusion (LVO) is unknown.

Methods We performed a retrospective review of observational data from 14 comprehensive stroke centers in nine US states with acute LVO. EVT metrics were compared between March to July 2019 against March to July 2020 (primary analysis), and between statespecific pre-peak and peak COVID-19 months (secondary analysis), with multivariable adjustment.

Results Of the 1364 patients included in the primary analysis (51% female, median NIHSS 14 …

Strategically Rational Risk Taking By Age In Covid-19, And The Heterogeneous Agent Behavioral Sir Model, Siamak Javadi, Elena Quercioli, Lones Smith

Economics and Finance Faculty Publications and Presentations

Given the dramatic age variation in COVID death rates, we create a heterogeneous agent version of the Behavioral SIR contagion model of Engle et al. (2020). The Bayes Nash equilibrium of our infection avoidance game yields a simple new log-linear relationship between the case fatality rate (CFR) and COVID incidence: Everyone knows that everyone optimizes vigilance both for the prevalence and their CFR. We explain 2020 CDC incidence data for the USA north-east in terms of the CFR to age-specific COVID death data for Massachusetts. Our model is statistically significant: A 10% higher CFR reduces incidence by about 1%.

Development Of Learners Engaging With Hispanic Communities To Address Covid-19 Inequities- Si Se Puede!, Giuiseppe A. Fonseca

MEDI 9331 Scholarly Activities Clinical Years

The coronavirus disease 2019 (COVID-19) pandemic has highlighted the health disparities that exist in marginalized communities across the country. Communities of color across the entire country have higher mortality and morbidity rates (Jordan 2020) due to COVID-19. The Rio Grande Valley (RGV) is a four-county region that consists of a population of over 90% Hispanic. Furthermore, the RGV harbors some of the highest rates of obesity, diabetes, and heart disease nationwide. The University of Texas Rio Grande Valley School of Medicine (UTRGVSOM) working alongside the Association of American Medical Colleges (AAMC) Nurturing Experiences for Tomorrow’s Community Leaders (NEXT) developed …

Covid-19 Student Mental Health Check, Dianna Blankenship, Irma S. Jones

Criminal Justice Faculty Publications and Presentations

The COVID-19 pandemic has produced many changes in the lives of our students and families. In this article, the responses of students in criminal justice classes at a Hispanic serving institution in south Texas were collected and synthesized. The 252 responses were divided into seven frequently observed and repeated themes: jobs and job related, school and courses, graduation, routine, family, positivity, and groceries/shopping. Findings for this time period matched what much of what the national and international news and reports have all reported. It indicates that, as teaching professionals, we must be mindful to provide the added support to assist …

Analysis Of Intervention Effectiveness Using Early Outbreak Transmission Dynamics To Guide Future Pandemic Management And Decision-Making In Kuwait, Michael G. Tyshenko, Tamer Oraby, Joseph C. Longenecker, Harri Vainio, Janvier Gasana, Walid Q. Alali, Mohammad Alseaidan, Susie Elsaadany, Mustafa Al-Zoughool

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a World Health Organization designated pandemic that can result in severe symptoms and death that disproportionately affects older patients or those with comorbidities. Kuwait reported its first imported cases of COVID-19 on February 24, 2020. Analysis of data from the first three months of community transmission of the COVID-19 outbreak in Kuwait can provide important guidance for decision-making when dealing with future SARS-CoV-2 epidemic wave management. The analysis of intervention scenarios can help to evaluate the possible impacts of various outbreak control measures going forward which aim to reduce the effective reproduction …

Comparing The Trends Of Postpartum Depression Screening Scores During And Before The Covid-19 Pandemic, Elif S. Duran, Dung Dang, Tony Ogburn

MEDI 9331 Scholarly Activities Clinical Years

Introduction:

Postpartum depression includes major and minor depressive disorders affecting women in the time period after childbirth. The studies reviewed in our literature found that the COVID-19 pandemic has increased the risk of postpartum depression for women. Our study location, the Rio Grande Valley is one of the hardest-hit locations by the COVID-19 pandemic in the United States. Our patient population is also one with the higher risk factors for postpartum depression. As such, we are expecting the psychological impact of the pandemic to be even more magnified, and thus, actions need to be taken to support the vulnerable population …

Mortality Outcomes In Therapeutic Versus Prophylactic Anticoagulation In Obese Patients In Predominantly Hispanic Population, Dave Patel, Moktar Ahmed Sheikh-Salah, Raul Garcia, Jewel Udenwagu, Jose Campo Maldonado, Christopher Romero

MEDI 9331 Scholarly Activities Clinical Years

Introduction: As of January 26, 2021, there have been 1,988,063 confirmed cases with 34,701 fatalities from COVID-19 in the state of Texas. As the fatalities increased in Rio Grande Valley, there was overwhelming evidence that showed that obesity, an already hypercoagulable state, was a risk factor that contributed to the severity of COVID-19 infection (Sanchis-Gomar, et. Al. 2020). The prevalence of obesity amongst the population in in the RGV presents an opportunity to correlate trends in outcomes with the obese population that are admitted for inpatient management of COVID-19.

Materials and Methods: This retrospective cohort study looks at patient’s electronic …

Sentiment Analysis Of Long-Term Social Data During The Covid-19 Pandemic, Sophanna Ek, Marco Curci, Xiaokun Yang, Beiyu Lin, Pinchao Liu, Hailu Xu

Computer Science Faculty Publications and Presentations

The COVID-19 pandemic has bringing the “infodemic” in the social media worlds. Various social platforms play a significant role in instantly acquiring the latest updates of the pandemic. Social media such as Twitter and Facebook produce vast amounts of posts related to the virus, vaccines, economics, and politics. In order to figure out how public opinion and sentiments are expressed during the pandemic, this work analyzes the long-term social posts from social media and conducts sentiment analysis on tweets within 12 months. Our findings show the trend topics of long-term social communities during the pandemic and express people’s attitudes towards …

Association Between Race/Ethnicity And Covid-19 Disease Outcomes In The United States: A Qualitative Systematic Review Of The Literature, Jacob Smith

MEDI 9331 Scholarly Activities Clinical Years

Background/Objective: As studies have shown disparities in coronavirus disease-19 prevalence and severity, we sought to evaluate differences in outcomes of acute SARS-CoV-2 infection by race/ethnicity.

Design: Systematic review

Data Source: Studies from PubMed were included.

Review methods: Articles published in English language from January 1, 2019 through March 22, 2020. Studies included were observational studies that examined racial or ethnic disparities in SARS-CoV-2 infection outcomes in the United States. One reviewer performed data extraction.

Results: Out of a possible 1,944 articles, 99 observational studies (82 individual-level and 17 population-level) were included. Differential rates of hospitalization or otherwise severe illness …

Crispr Systems For Covid-19 Diagnosis, Hossein Rahimi, Marziyeh Salehiabar, Murat Barsbay, Mohammadreza Ghaffarlou, Taras Kavetskyy, Ali Sharafi, Soodabeh Davaran, Subhash C. Chauhan, Hossein Danafar, Murali M. Yallapu

School of Medicine Publications and Presentations

The emergence of the new coronavirus 2019 (COVID-19) was first seen in December 2019, which has spread rapidly and become a global pandemic. The number of cases of COVID-19 and its associated mortality have raised serious concerns worldwide. Early diagnosis of viral infection undoubtedly allows rapid intervention, disease management, and substantial control of the rapid spread of the disease. Currently, the standard approach for COVID-19 diagnosis globally is the RTqPCR test; however, the limited access to kits and associated reagents, the need for specialized lab equipment, and the need for highly skilled personnel has led to a detection slowdown. Recently, …

Stroke Etiologies In Patients With Covid-19: The Svin Covid-19 Multinational Registry, María E. Ramos-Araque, James E. Siegler, Marc Ribo, Manuel Requena, Cristina López, Mercedes De Lera, Juan F. Arenillas, Isabel Hernández Pérez, Beatriz Gómez-Vicente, Ameer E. Hassan

School of Medicine Publications and Presentations

Background and purpose: Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause of which is frequently cryptogenic. In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and inhospital mortality among patients according to stroke etiology.

Methods: We explored clinical characteristics and short-term outcomes of consecutively evaluated patients 18 years of age or older with acute ischemic stroke (AIS) and laboratory-confirmed COVID-19 from 31 hospitals in 4 countries (3/1/20–6/16/20).

Results:Of the 14.483 laboratory-confirmed patients with COVID-19, 156 (1.1%) were diagnosed …