Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Genetic Analysis Of Cortical Thickness And Fractional Anisotropy Of Water Diffusion In The Brain, Peter Kochunov, David C. Glahn, Thomas E. Nichols, Anderson M. Winkler, Elliot L. Hong, Joanne E. Curran, Rene L. Olvera, Matthew P. Johnson, Shelley A. Cole, John Blangero
Genetic Analysis Of Cortical Thickness And Fractional Anisotropy Of Water Diffusion In The Brain, Peter Kochunov, David C. Glahn, Thomas E. Nichols, Anderson M. Winkler, Elliot L. Hong, Joanne E. Curran, Rene L. Olvera, Matthew P. Johnson, Shelley A. Cole, John Blangero
School of Medicine Publications and Presentations
Objectives: The thickness of the brain’s cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated by common biological mechanisms. We employed four types of genetic analyses to localize individual genes acting pleiotropically upon these phenotypes.
Methods: Whole-brain and regional GM thickness and FA values were measured from high-resolution anatomical and diffusion tensor MR images collected from 712, Mexican American participants (438 females, age = 47.9 ± 13.2 years) recruited from 73 (9.7 ± 9.3 individuals/family) large …