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University of Texas Rio Grande Valley
Health & Biomedical Sciences Faculty Publications and Presentations
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Full-Text Articles in Medicine and Health Sciences
Bioactive Food Components And Their Inhibitory Actions In Multiple Platelet Pathways, Diptimayee Das, Shubhamay Adhikary, Ranjit Kumar Das, Antara Banerjee, Arun Kumar Radhakrishnan, Sujay Paul, Surajit Pathak, Asim K. Duttaroy
Bioactive Food Components And Their Inhibitory Actions In Multiple Platelet Pathways, Diptimayee Das, Shubhamay Adhikary, Ranjit Kumar Das, Antara Banerjee, Arun Kumar Radhakrishnan, Sujay Paul, Surajit Pathak, Asim K. Duttaroy
Health & Biomedical Sciences Faculty Publications and Presentations
In addition to hemostasis and thrombosis, blood platelets are involved in various processes such as inflammation, infection, immunobiology, cancer metastasis, wound repair and angiogenesis. Platelets' hemostatic and non-hemostatic functions are mediated by the expression of various membrane receptors and the release of proteins, ions and other mediators. Therefore, specific activities of platelets responsible for the non-hemostatic disease are to be inhibited while leaving the platelet's hemostatic function unaffected. Platelets' anti-aggregatory property has been used as a primary criterion for antiplatelet drugs/bioactives; however, their non-hemostatic activities are not well known. This review describes the hemostatic and non-hemostatic function of human blood …
Association Of Interleukin-6 Polymorphisms With Obesity Or Metabolic Traits In Young Mexican-Americans, K. Boeta-Lopez, J. Duran, D. Elizondo, E. Gonzales, Anne R. Rentfro, Andrea E. Schwarzbach, Saraswathy Nair
Association Of Interleukin-6 Polymorphisms With Obesity Or Metabolic Traits In Young Mexican-Americans, K. Boeta-Lopez, J. Duran, D. Elizondo, E. Gonzales, Anne R. Rentfro, Andrea E. Schwarzbach, Saraswathy Nair
Health & Biomedical Sciences Faculty Publications and Presentations
Objective The objective of the study is to investigate the association of interleukin-6 (IL6) promoter single-nucleotide polymorphisms rs1800797 (-597 G/A) and rs1800796 (-572 G/C) with obesity or metabolic syndrome in Mexican-Americans.
Methods The rs1800797 and rs1800796 single-nucleotide polymorphisms were genotyped in Mexican-Americans (n = 437) from South Texas, and results were correlated with measures of obesity and metabolic syndrome including body mass index, waist circumference, blood pressure, cholesterol, triglycerides, glucose, liver enzymes, plasma IL6 and high-sensitive C-reactive protein (hs-CRP).
Results Significant associations were found for the rs1800796 variant with increased waist circumference, insulin resistance, lower IL6 levels and higher hs-CRP …