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Full-Text Articles in Medicine and Health Sciences
The Role Of Secretory Phospholipase A2 Group Iia In Obesity And Metabolism, Michael S. Kuefner
The Role Of Secretory Phospholipase A2 Group Iia In Obesity And Metabolism, Michael S. Kuefner
Theses and Dissertations (ETD)
Secretory phospholipase A2 group IIA (PLA2G2A) is a member of a family of secretory phospholipases previously implicated in inflammation, atherogenesis, and antibacterial actions. These enzymes hydrolyze glycerophospholipids at the sn-2 position releasing lysophospholipids and fatty acids. Though studies have shown PLA2G2A is pro-inflammatory and promotes atherosclerosis, no research has analyzed the role of this enzyme in obesity and metabolism. Studies in the past 5-10 years utilizing various knock- out or over-expression mouse models have analyzed the role of different secretory phospholipase A2s (sPLA2) in metabolic diseases. From these studies, it is known that at least seven of the 11 sPLA2 …
An Assessment Of Utilization Of Prescription Anti-Hypertension Medications Via A Health Records Database, Ryan Payne
An Assessment Of Utilization Of Prescription Anti-Hypertension Medications Via A Health Records Database, Ryan Payne
Applied Research Projects
Obesity is a growing problem in the United States, though not a new one. It was estimated that over 72 million U.S. adults alone have a diagnosis of obesity. Among all preventable premature deaths, obesity ranks as the second leading cause. Contemporary classifications define obesity as a body mass index (BMI) greater than or equal to 30. Several common comorbidities are widely present in obese populations, particularly hypertension, diabetes, and hyperlipidemia. Among these chronic disease states, hypertension has been identified as the most common and earliest identifiable. The purpose of this study was to make inferences on the prescribing of …