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Preclinical Pharmacology Of The Mdm2 Antagonist Nutlin-3a, Fan Zhang
Preclinical Pharmacology Of The Mdm2 Antagonist Nutlin-3a, Fan Zhang
Theses and Dissertations (ETD)
Nutlin-3a is an MDM2-p53 interaction antagonist that is under investigation in preclinical models for a variety of pediatric malignancies, including neuroblastoma, retinoblastoma, leukemia, and rhabdomyosarcoma. In the current research, we conducted preclinical pharmacology studies of nutlin-3a to evaluate the synergistic effect of the nutlin-3a and topotecan combination on neuroblastoma cell growth, to assess the effect of nutlin-3a on breast cancer resistance protein (BCRP), and to characterize the disposition of nutlin-3a in the mouse plasma and multiple tissues.
Activating the p53 pathway might offer a new therapy for neuroblastoma. In the first part of the study, we assessed the effect of …