Medicine and Health Sciences Commons^™

Choosing A Medical Specialty: The Difference Between What Students Want And What Society Needs, David M. Mirvis

Faculty Publications and Other Works -- UT Graduate School of Medicine

The choice of a specialty by medical students is a complex one that has significant implications for the future supply of physician manpower. The study by Weissman et al. portrays this choice as reflecting the degree of congruence between a student’s needs and values and his or her perception of the characteristics of the various specialties. The existing shortages in the supply of various specialists in Israel may be interpreted as signifying a lack of alignment of student needs and perceptions. This commentary will extend the implications of this work to include the connection between students’ choices and the physician …

Odontogenic Ameloblast-Associated Protein (Odam) Inhibits Growth And Migration Of Human Melanoma Cells And Elicits Pten Elevation And Inactivation Of Pi3k/Akt Signaling, James S. Foster, Lindsay M. Fish, Jonathan E. Phipps, Charles T. Bruker, James M. Lewis, John L. Bell, Alan Solomon, Daniel P. Kestler

Faculty Publications and Other Works -- UT Graduate School of Medicine

Background

The Odontogenic Ameloblast-associated Protein (ODAM) is expressed in a wide range of normal epithelial, and neoplastic tissues, and we have posited that ODAM serves as a novel prognostic biomarker for breast cancer and melanoma. Transfection of ODAM into breast cancer cells yields suppression of cellular growth, motility, and in vivo tumorigenicity. Herein we have extended these studies to the effects of ODAM on cultured melanoma cell lines.

Methods

The A375 and C8161 melanoma cell lines were stably transfected with ODAM and assayed for properties associated with tumorigenicity including cell growth, motility, and extracellular matrix adhesion. In addition, ODAM–transfected cells …