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Articles 1 - 12 of 12
Full-Text Articles in Medicine and Health Sciences
On The Potential Therapeutic Roles Of Taurine In Autism Spectrum Disorder, Alberto Rubio-Casillas, Elrashdy M. Redwan, Vladimir N. Uversky
On The Potential Therapeutic Roles Of Taurine In Autism Spectrum Disorder, Alberto Rubio-Casillas, Elrashdy M. Redwan, Vladimir N. Uversky
Molecular Medicine Faculty Publications
Contemporary research has found that people with autism spectrum disorder (ASD) exhibit aberrant immunological function, with a shift toward increased cytokine production and unusual cell function. Microglia and astroglia were found to be significantly activated in immuno-cytochemical studies, and cytokine analysis revealed that the macrophage chemoattractant protein-1 (MCP-1), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and transforming growth factor β-1 (TGFB-1), all generated in the neuroglia, constituted the most predominant cytokines in the brain. Taurine (2-aminoethanesulfonic acid) is a promising therapeutic molecule able to increase the activity of antioxidant enzymes and ATPase, which may be protective against aluminum-induced neurotoxicity. …
Can Covid-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading To?, Altijana Hromić-Jahjefendić, Debmalya Barh, Vladimir N. Uversky, Alaa A. A. Aljabali, Murtaza M. Tambuwala, Fuad M. Alzahrani, Saleh Alshammeri, Kenneth Lundstrom
Can Covid-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading To?, Altijana Hromić-Jahjefendić, Debmalya Barh, Vladimir N. Uversky, Alaa A. A. Aljabali, Murtaza M. Tambuwala, Fuad M. Alzahrani, Saleh Alshammeri, Kenneth Lundstrom
Molecular Medicine Faculty Publications
According to the WHO, as of January 2023, more than 850 million cases and over 6.6 million deaths from COVID-19 have been reported worldwide. Currently, the death rate has been reduced due to the decreased pathogenicity of new SARS-CoV-2 variants, but the major factor in the reduced death rates is the administration of more than 12.8 billion vaccine doses globally. While the COVID-19 vaccines are saving lives, serious side effects have been reported after vaccinations for several premature non-communicable diseases (NCDs). However, the reported adverse events are low in number. The scientific community must investigate the entire spectrum of COVID-19-vaccine-induced …
Pre-Molten, Wet, And Dry Molten Globules En Route To The Functional State Of Proteins, Munishwar Nath Gupta, Vladimir N. Uversky
Pre-Molten, Wet, And Dry Molten Globules En Route To The Functional State Of Proteins, Munishwar Nath Gupta, Vladimir N. Uversky
Molecular Medicine Faculty Publications
Transitions between the unfolded and native states of the ordered globular proteins are accompanied by the accumulation of several intermediates, such as pre-molten globules, wet molten globules, and dry molten globules. Structurally equivalent conformations can serve as native functional states of intrinsically disordered proteins. This overview captures the characteristics and importance of these molten globules in both structured and intrinsically disordered proteins. It also discusses examples of engineered molten globules. The formation of these intermediates under conditions of macromolecular crowding and their interactions with nanomaterials are also reviewed.
Limosilactobacillus Fermentum 3872 That Produces Class Iii Bacteriocin Forms Co-Aggregates With The Antibiotic-Resistant Staphylococcus Aureus Strains And Induces Their Lethal Damage, Vyacheslav M. Abramov, Igor V. Kosarev, Andrey V. Machulin, Tatiana V. Priputnevich, Eugenia I. Deryusheva, Ekaterina L. Nemashkalova, Irina O. Chikileva, Tatiana N. Abashina, Alexander N. Panin, Vyacheslav G. Melnikov, Natalia E. Suzina, Ilya N. Nikonov, Marina V. Selina, Valentin S. Khlebnikov, Vadim K. Sakulin, Vladimir A. Samoilenko, Alexey B. Gordeev, Gennady T. Sukhikh, Vladimir N. Uversky, Andrey V. Karlyshev
Limosilactobacillus Fermentum 3872 That Produces Class Iii Bacteriocin Forms Co-Aggregates With The Antibiotic-Resistant Staphylococcus Aureus Strains And Induces Their Lethal Damage, Vyacheslav M. Abramov, Igor V. Kosarev, Andrey V. Machulin, Tatiana V. Priputnevich, Eugenia I. Deryusheva, Ekaterina L. Nemashkalova, Irina O. Chikileva, Tatiana N. Abashina, Alexander N. Panin, Vyacheslav G. Melnikov, Natalia E. Suzina, Ilya N. Nikonov, Marina V. Selina, Valentin S. Khlebnikov, Vadim K. Sakulin, Vladimir A. Samoilenko, Alexey B. Gordeev, Gennady T. Sukhikh, Vladimir N. Uversky, Andrey V. Karlyshev
Molecular Medicine Faculty Publications
LF3872 was isolated from the milk of a healthy lactating and breastfeeding woman. Earlier, the genome of LF3872 was sequenced, and a gene encoding unique bacteriocin was discovered. We have shown here that the LF3872 strain produces a novel thermolabile class III bacteriolysin (BLF3872), exhibiting antimicrobial activity against antibiotic-resistant Staphylococcus aureus strains. Sequence analysis revealed the two-domain structural (lysozyme-like domain and peptidase M23 domain) organization of BLF3872. At least 25% residues of this protein are expected to be intrinsically disordered. Furthermore, BLF3872 is predicted to have a very high liquid-liquid phase separation. According to the electron microscopy data, the bacterial …
Exploring The Mechanisms By Which Camel Lactoferrin Can Kill Salmonella Enterica Serovar Typhimurium And Shigella Sonnei, Hussein A. Almehdar, Nawal Abd El-Baky, Ehab H. Mattar, Raed S. Albiheyri, Atif Bamagoos, Abdullah A. Aljaddawi, Vladimir N. Uversky, Elrashdy M. Redwan
Exploring The Mechanisms By Which Camel Lactoferrin Can Kill Salmonella Enterica Serovar Typhimurium And Shigella Sonnei, Hussein A. Almehdar, Nawal Abd El-Baky, Ehab H. Mattar, Raed S. Albiheyri, Atif Bamagoos, Abdullah A. Aljaddawi, Vladimir N. Uversky, Elrashdy M. Redwan
Molecular Medicine Faculty Publications
There is a continuously increasing pressure associated with the appearance of Salmonella enterica Serovar typhimurium (S. typhimurium) and Shigella sonnei (S. sonnei) that have developed pathogenic multiple antibiotic resistance and the cost of cure and control of these enterobacteriaceae infections increases annually. The current report for first time demonstrated the distinguished antimicrobial action of camel lactoferrin (cLf) obtained from the milk of different clans of camel in Saudi Arabia against S. typhimurium and S. sonnei. These cLf subtypes showed comparable antimicrobial potential when tested against the two bacterial strains but were superior to either bovine (bLf) …
Liaisons Dangereuses: Intrinsic Disorder In Cellular Proteins Recruited To Viral Infection-Related Biocondensates, Greta Bianchi, Stefania Brocca, Sonia Longhi, Vladimir N. Uversky
Liaisons Dangereuses: Intrinsic Disorder In Cellular Proteins Recruited To Viral Infection-Related Biocondensates, Greta Bianchi, Stefania Brocca, Sonia Longhi, Vladimir N. Uversky
Molecular Medicine Faculty Publications
Liquid–liquid phase separation (LLPS) is responsible for the formation of so-called membrane-less organelles (MLOs) that are essential for the spatio-temporal organization of the cell. Intrinsically disordered proteins (IDPs) or regions (IDRs), either alone or in conjunction with nucleic acids, are involved in the formation of these intracellular condensates. Notably, viruses exploit LLPS at their own benefit to form viral replication compartments. Beyond giving rise to biomolecular condensates, viral proteins are also known to partition into cellular MLOs, thus raising the question as to whether these cellular phase-separating proteins are drivers of LLPS or behave as clients/regulators. Here, we focus on …
Yield And Composition Variations Of The Milk From Different Camel Breeds In Saudi Arabia, Amr A. El-Hanafy, Yasser M. Saad, Saleh A. Alkarim, Hussein A. Almehdar, Fuad M. Alzahrani, Mohammed A. Almatry, Vladimir N. Uversky, Elrashdy M. Redwan
Yield And Composition Variations Of The Milk From Different Camel Breeds In Saudi Arabia, Amr A. El-Hanafy, Yasser M. Saad, Saleh A. Alkarim, Hussein A. Almehdar, Fuad M. Alzahrani, Mohammed A. Almatry, Vladimir N. Uversky, Elrashdy M. Redwan
Molecular Medicine Faculty Publications
With the increasing interest in the identification of differences between camel breeds over the last decade, this study was conducted to estimate the variability of milk production and composition of four Saudi camel breeds during different seasons. Milk records were taken two days per week from females of Majahem, Safra, Wadha, and Hamra breeds distributed over Saudi Arabia. The milk yield during winter indicated that the weekly average of the Wadha breed was significantly lower (27.13 kg/week) than Majahem and Hamra breeds. The Safra breed had the lowest milk yield (30.7 kg/week) during summer. During winter, the Hamra breed had …
From The Hydrophobic Core To The Globular-Disorder Interface: New Challenges And Insights Into Protein Design, Sankar Basu, Devlina Chakravarty, Qingzhen Hou, Vladimir N. Uversky
From The Hydrophobic Core To The Globular-Disorder Interface: New Challenges And Insights Into Protein Design, Sankar Basu, Devlina Chakravarty, Qingzhen Hou, Vladimir N. Uversky
Molecular Medicine Faculty Publications
No abstract provided.
Advanced Phytochemical-Based Nanocarrier Systems For The Treatment Of Breast Cancer, Vivek P. Chavda, Lakshmi Vineela Nalla, Pankti Balar, Rajashri Bezbaruah, Vasso Apostolopoulos, Rajeev K. Singla, Avinash Khadela, Lalitkumar K. Vora, Vladimir N. Uversky
Advanced Phytochemical-Based Nanocarrier Systems For The Treatment Of Breast Cancer, Vivek P. Chavda, Lakshmi Vineela Nalla, Pankti Balar, Rajashri Bezbaruah, Vasso Apostolopoulos, Rajeev K. Singla, Avinash Khadela, Lalitkumar K. Vora, Vladimir N. Uversky
Molecular Medicine Faculty Publications
As the world’s most prevalent cancer, breast cancer imposes a significant societal health burden and is among the leading causes of cancer death in women worldwide. Despite the notable improvements in survival in countries with early detection programs, combined with different modes of treatment to eradicate invasive disease, the current chemotherapy regimen faces significant challenges associated with chemotherapy-induced side effects and the development of drug resistance. Therefore, serious concerns regarding current chemotherapeutics are pressuring researchers to develop alternative therapeutics with better efficacy and safety. Due to their extremely biocompatible nature and efficient destruction of cancer cells via numerous mechanisms, phytochemicals …
Sumoylation-Mediated Psme3-20s Proteasomal Degradation Of Transcription Factor Cp2c Is Crucial For Cell Cycle Progression, Seung Han Son, Min Young Kim, Young Su Lim, Hyeon Cheol Jin, June Ho Shin, Jae Kyu Yi, Sungwoo Choi, Mi Ae Park, Ji Hyung Chae, Ho Chul Kang, Young Jin Lee, Vladimir N. Uversky, Chul Geun Kim
Sumoylation-Mediated Psme3-20s Proteasomal Degradation Of Transcription Factor Cp2c Is Crucial For Cell Cycle Progression, Seung Han Son, Min Young Kim, Young Su Lim, Hyeon Cheol Jin, June Ho Shin, Jae Kyu Yi, Sungwoo Choi, Mi Ae Park, Ji Hyung Chae, Ho Chul Kang, Young Jin Lee, Vladimir N. Uversky, Chul Geun Kim
Molecular Medicine Faculty Publications
Transcription factor CP2c (also known as TFCP2, α-CP2, LSF, and LBP-1c) is involved in diverse ubiquitous and tissue/stage-specific cellular processes and in human malignancies such as cancer. Despite its importance, many fundamental regulatory mechanisms of CP2c are still unclear. Here, we uncover an unprecedented mechanism of CP2c degradation via a previously unidentified SUMO1/PSME3/20S proteasome pathway and its biological meaning. CP2c is SUMOylated in a SUMO1-dependent way, and SUMOylated CP2c is degraded through the ubiquitin-independent PSME3 (also known as REGγ or PA28)/20S proteasome system. SUMOylated PSME3 could also interact with CP2c to degrade CP2c via the 20S proteasomal pathway. Moreover, precisely …
Paving The Way For Synthetic Intrinsically Disordered Polymers For Soft Robotics, Orkid Coskuner-Weber, Elif Yuce-Erarslan, Vladimir N. Uversky
Paving The Way For Synthetic Intrinsically Disordered Polymers For Soft Robotics, Orkid Coskuner-Weber, Elif Yuce-Erarslan, Vladimir N. Uversky
Molecular Medicine Faculty Publications
Nature is full of examples of processes that, through evolution, have been perfected over the ages to effectively use matter and sustain life. Here, we present our strategies for designing intrinsically disordered smart polymers for soft robotics applications that are bio-inspired by intrinsically disordered proteins. Bio-inspired intrinsically disordered smart and soft polymers designed using our deep understanding of intrinsically disordered proteins have the potential to open new avenues in soft robotics. Together with other desirable traits, such as robustness, dynamic self-organization, and self-healing abilities, these systems possess ideal characteristics that human-made formations strive for but often fail to achieve. Our …
Biomolecular Condensates: Insights Into Early And Late Steps Of The Hiv-1 Replication Cycle, Francesca Di Nunzio, Vladimir N. Uversky, Andrew J. Mouland
Biomolecular Condensates: Insights Into Early And Late Steps Of The Hiv-1 Replication Cycle, Francesca Di Nunzio, Vladimir N. Uversky, Andrew J. Mouland
Molecular Medicine Faculty Publications
A rapidly evolving understanding of phase separation in the biological and physical sciences has led to the redefining of virus-engineered replication compartments in many viruses with RNA genomes. Condensation of viral, host and genomic and subgenomic RNAs can take place to evade the innate immunity response and to help viral replication. Divergent viruses prompt liquid–liquid phase separation (LLPS) to invade the host cell. During HIV replication there are several steps involving LLPS. In this review, we characterize the ability of individual viral and host partners that assemble into biomolecular condensates (BMCs). Of note, bioinformatic analyses predict models of phase separation …