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Full-Text Articles in Medicine and Health Sciences
Short Linear Motifs Recognized By Sh2, Sh3 And Ser/Thr Kinase Domains Are Conserved In Disordered Protein Regions, Siyun Ren, Vladimir N. Uversky, Zhengjun Chen, A. Keith Dunker, Zoran Obradovic
Short Linear Motifs Recognized By Sh2, Sh3 And Ser/Thr Kinase Domains Are Conserved In Disordered Protein Regions, Siyun Ren, Vladimir N. Uversky, Zhengjun Chen, A. Keith Dunker, Zoran Obradovic
Molecular Medicine Faculty Publications
Background: Protein interactions are essential for most cellular functions. Interactions mediated by domains that appear in a large number of proteins are of particular interest since they are expected to have an impact on diversities of cellular processes such as signal transduction and immune response. Many well represented domains recognize and bind to primary sequences less than 10 amino acids in length called Short Linear Motifs (SLiMs).
Results: In this study, we systematically studied the evolutionary conservation of SLiMs recognized by SH2, SH3 and Ser/Thr Kinase domains in both ordered and disordered protein regions. Disordered protein regions are protein sequences …