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Full-Text Articles in Medicine and Health Sciences
Reelin Supplementation For The Rescue Of Fragile X Syndrome., Nicole K. Morrill
Reelin Supplementation For The Rescue Of Fragile X Syndrome., Nicole K. Morrill
USF Tampa Graduate Theses and Dissertations
Reelin is a large, extracellular matrix glycoprotein involved in neuronal migration during embryonic brain development and synaptic plasticity in the adult brain. Reelin consists of eight EGF-like repeats and undergoes natural cleavage at two sites, between repeats 2 and 3 and repeats 5 and 6, resulting in five naturally occurring fragments. The role of Reelin in the developing central nervous system has been extensively characterized, and loss of Reelin or disruption in the signaling cascade may contribute to the cognitive impairments seen in numerous neurodevelopmental or aging diseases such as schizophrenia, autism, depression, epilepsy, and Alzheimer’s disease. Reelin’s signaling potentiates …
Small Heat Shock Protein 22 Preserves Neuronal Function In A Murine Model Of Tauopathy, Santiago Rodriguez Ospina
Small Heat Shock Protein 22 Preserves Neuronal Function In A Murine Model Of Tauopathy, Santiago Rodriguez Ospina
USF Tampa Graduate Theses and Dissertations
Proteinopathies is a family of diseases associated with the pathological aggregation of protein. There are a multitude of proteinopathies, like tauopathy and synucleinopathy that contribute to neurodegenerative diseases like Alzheimer’s disease (AD), Creutzfeldt-Jakob, Pick’s disease, Frontotemporal dementia, and Parkinson’s disease (PD). Currently, one focus of research in the field is mitigating aggregation-prone proteins contributing to disease state. One method of targeting aggregation is the use of chaperones. Chaperones are molecular machinery that help maintain homeostasis in the cells, through various roles and mechanisms, one of those methods is to regulate protein aggregation. Chaperones can achieve this by affecting protein-protein interactions, …