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Full-Text Articles in Medicine and Health Sciences
Mesenchymal Stem Cell Therapy Alleviates The Neuroinflammation Associated With Acquired Brain Injury, Brooke Bonsack, Sydney Corey, Alex Shear, Matt Heyck, Blaise Cozene, Nadia Sadanandan, Henry Zhang, Bella Gonzales-Portillo, Michael Sheyner, Cesar V. Borlongan
Mesenchymal Stem Cell Therapy Alleviates The Neuroinflammation Associated With Acquired Brain Injury, Brooke Bonsack, Sydney Corey, Alex Shear, Matt Heyck, Blaise Cozene, Nadia Sadanandan, Henry Zhang, Bella Gonzales-Portillo, Michael Sheyner, Cesar V. Borlongan
Neurosurgery and Brain Repair Faculty Publications
Ischemic stroke and traumatic brain injury (TBI) comprise two particularly prevalent and costly examples of acquired brain injury (ABI). Following stroke or TBI, primary cell death and secondary cell death closely model disease progression and worsen outcomes. Mounting evidence indicates that long-term neuroinflammation extensively exacerbates the secondary deterioration of brain structure and function. Due to their immunomodulatory and regenerative properties, mesenchymal stem cell transplants have emerged as a promising approach to treating this facet of stroke and TBI pathology. In this review, we summarize the classification of cell death in ABI and discuss the prominent role of inflammation. We then …
Potential Of Mesenchymal Stem Cells Alone, Or In Combination, To Treat Traumatic Brain Injury, Alison E. Willing, Mahasweta Das, Mark Howell, Shyam S. Mohapatra, Subhra Mohapatra
Potential Of Mesenchymal Stem Cells Alone, Or In Combination, To Treat Traumatic Brain Injury, Alison E. Willing, Mahasweta Das, Mark Howell, Shyam S. Mohapatra, Subhra Mohapatra
Neurosurgery and Brain Repair Faculty Publications
Traumatic brain injury (TBI) causes death and disability in the United States and around the world. The traumatic insult causes the mechanical injury of the brain and primary cellular death. While a comprehensive pathological mechanism of TBI is still lacking, the focus of the TBI research is concentrated on understanding the pathophysiology and developing suitable therapeutic approaches. Given the complexities in pathophysiology involving interconnected immunologic, inflammatory, and neurological cascades occurring after TBI, the therapies directed to a single mechanism fail in the clinical trials. This has led to the development of the paradigm of a combination therapeutic approach against TBI. …