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Population Analysis Of Adverse Events In Different Age Groups Using Big Clinical Trials Data, Jake Luo, Christina Eldredge, Chi C. Cho, Ron A. Cisler
Population Analysis Of Adverse Events In Different Age Groups Using Big Clinical Trials Data, Jake Luo, Christina Eldredge, Chi C. Cho, Ron A. Cisler
School of Information Faculty Publications
BACKGROUND: Understanding adverse event patterns in clinical studies across populations is important for patient safety and protection in clinical trials as well as for developing appropriate drug therapies, procedures, and treatment plans.
OBJECTIVES: The objective of our study was to conduct a data-driven population-based analysis to estimate the incidence, diversity, and association patterns of adverse events by age of the clinical trials patients and participants.
METHODS: Two aspects of adverse event patterns were measured: (1) the adverse event incidence rate in each of the patient age groups and (2) the diversity of adverse events defined as distinct types of adverse …