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Baicalein Inhibits Heparin-Induced Tau Aggregation By Initializing Non-Toxic Tau Oligomer Formation, Shweta Kishor Sonawane, Vladimir N. Uversky, Subashchandrabose Chinnathambi

Molecular Medicine Faculty Publications

Background: Amyloid aggregate deposition is the key feature of Alzheimer’s disease. The proteinaceous aggregates found in the afflicted brain are the intra-neuronal neurofibrillary tangles formed by the microtubule-associated protein Tau and extracellular deposits, senile plaques, of amyloid beta (Aβ) peptide proteolytically derived from the amyloid precursor protein. Accumulation of these aggregates has manifestations in the later stages of the disease, such as memory loss and cognitive inabilities originating from the neuronal dysfunction, neurodegeneration, and brain atrophy. Treatment of this disease at the late stages is difficult, and many clinical trials have failed. Hence, the goal is to find means capable …