Medicine and Health Sciences Commons^™

Prediction Of Disordered Regions And Their Roles In The Anti-Pathogenic And Immunomodulatory Functions Of Butyrophilins, Elrashdy M. Redwan, Ahmed M. Al-Hejin, Hussein A. Almehdar, Abdulrahman Elsaway, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Butyrophilins (BTNs) are a group of the moonlighting proteins, some members of which are secreted in milk. They constitute a large family of structurally similar type 1 transmembrane proteins from the immunoglobulin superfamily. Although the founding member of this family is related to lactation, participating in the secretion, formation and stabilization of milk fat globules, it may also have a cell surface receptor function. Generally, the BTN family members are known to modulate co-stimulatory responses, T cell selection, differentiation, and cell fate determination. Polymorphism of these genes was shown to be associated with the pathology of several human diseases. Despite …