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Effects Of Hmgn Variants On The Cellular Transcription Profile, Mark Rochman, Leila Taher, Toshihiro Kurahashi, Srujana Cherukuri, Vladimir N. Uversky, David Landsman, Ivan Ovcharenko, Michael Bustin

Molecular Medicine Faculty Publications

High mobility group N (HMGN) is a family of intrinsically disordered nuclear proteins that bind to nucleosomes, alters the structure of chromatin and affects transcription. A major unresolved question is the extent of functional specificity, or redundancy, between the various members of the HMGN protein family. Here, we analyze the transcriptional profile of cells in which the expression of various HMGN proteins has been either deleted or doubled. We find that both up- and downregulation of HMGN expression altered the cellular transcription profile. Most, but not all of the changes were variant specific, suggesting limited redundancy in transcriptional regulation. Analysis …