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Full-Text Articles in Medicine and Health Sciences
Intrinsic Disorder Is A Common Feature Of Hub Proteins From Four Eukaryotic Interactomes, Chad Haynes, Christopher J. Oldfield, Fei Ji, Niels Klitgord, Michael E. Cusick, Predrag Radivojac, Vladimir N. Uversky, Mark Vidal, Lilia M. Iakoucheva
Intrinsic Disorder Is A Common Feature Of Hub Proteins From Four Eukaryotic Interactomes, Chad Haynes, Christopher J. Oldfield, Fei Ji, Niels Klitgord, Michael E. Cusick, Predrag Radivojac, Vladimir N. Uversky, Mark Vidal, Lilia M. Iakoucheva
Molecular Medicine Faculty Publications
Recent proteome-wide screening approaches have provided a wealth of information about interacting proteins in various organisms. To test for a potential association between protein connectivity and the amount of predicted structural disorder, the disorder propensities of proteins with various numbers of interacting partners from four eukaryotic organisms (Caenorhabditis elegans, Saccharomyces cerevisiae, Drosophila melanogaster, and Homo sapiens) were investigated. The results of PONDR VL-XT disorder analysis show that for all four studied organisms, hub proteins, defined here as those that interact with ≥10 partners, are significantly more disordered than end proteins, defined here as those that interact with just one partner. …