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Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Seeing The Big Picture: System Architecture Trends In Endoscopy And Led-Based Hyperspectral Subsystem Intergration, Craig M. Browning
Seeing The Big Picture: System Architecture Trends In Endoscopy And Led-Based Hyperspectral Subsystem Intergration, Craig M. Browning
<strong> Theses and Dissertations </strong>
Early-stage colorectal lesions remain difficult to detect. Early development of neoplasia tends to be small (less than 10 mm) and flat and difficult to distinguish from surrounding mucosa. Additionally, optical diagnosis of neoplasia as benign or malignant is problematic. Low rates of detection of these lesions allow for continued growth in the colorectum and increased risk of cancer formation. Therefore, it is crucial to detect neoplasia and other non-neoplastic lesions to determine risk and guide future treatment. Technology for detection needs to enhance contrast of subtle tissue differences in the colorectum and track multiple biomarkers simultaneously. This work implements one …
How Valuable Are Clinical Neuropsychological Assessments? A Meta-Analysis Of Neuropsychological Tests With Comparison To Common Medical Tests And Treatments, Murphy N. Harrell
How Valuable Are Clinical Neuropsychological Assessments? A Meta-Analysis Of Neuropsychological Tests With Comparison To Common Medical Tests And Treatments, Murphy N. Harrell
<strong> Theses and Dissertations </strong>
There has been a general decrease in neuropsychological assessments at a time when medical diagnostic technology and treatments have expanded, leading to a faulty assumption that medical tests and healthcare treatments provide more reliable or valid data than psychological assessments. A landmark report from the American Psychological Association’s (APA) Psychological Assessment Work Group (PAWG) found that validity coefficients for many psychological tests were indistinguishable from those of medical tests (Meyer et al., 2001). An updated systematic review of the advancement in neuropsychological testing is essential to the continued advancement of the value of neuropsychological assessment in healthcare. This meta-analysis sought …
Infection And Transmission Determinants Of Flea-Borne Rickettsioses, Hanna J. Laukaitis
Infection And Transmission Determinants Of Flea-Borne Rickettsioses, Hanna J. Laukaitis
<strong> Theses and Dissertations </strong>
The genus Rickettsia is comprised of Gram-negative, obligate intracellular bacteria that are spread by hematophagous arthropods. Elucidating the factors conferring rickettsial virulence has perplexed investigators for decades, complicated by the lack of efficient genetic tools necessary to uncover rickettsial- and vector-specific factors contributing to persistence. The advent of transposon mutagenesis has enabled the field to make vast developments in uncovering novel rickettsial mechanisms utilized in various host backgrounds. Thus, the aim of this study was to generate Rickettsia felis transposon mutants and characterize novel phenotypes associated with genetic disruption in an arthropod background. Distribution of rickettsiae is reliant on the …
An Examination Of Sex-Differences In Quadriceps Fatigability During High- And Low-Intensity Contractions, Katie G. Kennedy
An Examination Of Sex-Differences In Quadriceps Fatigability During High- And Low-Intensity Contractions, Katie G. Kennedy
<strong> Theses and Dissertations </strong>
The purpose of the current study was to compare sex-differences in quadriceps fatigability following both high- and low-intensity repeated, isometric contractions. Twenty-four (12 males, 12 females) participants completed two experimental visits consisting of repeated, isometric contractions of the knee extensors at 30% (LT) and 70% (HT) of maximal voluntary force (MVIC) until failure. Prior to, and immediately following the fatiguing contractions, strength, voluntary activation (VA), and peak twitch torque (PTT) were assessed while measuring surface electromyographic amplitude of the vastus lateralis (VLAMP) and vastus medialis (VMAMP ). Fatiguing bouts were assessed via mean torque (TQMEAN), total repetitions completed, torque coefficient …
Role Of Type 4 Phosphodiesterases In Thermoregulation And Salivation In Mice, Abigail Grace Boyd
Role Of Type 4 Phosphodiesterases In Thermoregulation And Salivation In Mice, Abigail Grace Boyd
<strong> Theses and Dissertations </strong>
Type 4 cAMP phosphodiesterases (PDE4s) comprise a family of four isoenzymes, PDE4A to D, that hydrolyze and inactivate the second messenger cAMP. Non/PAN selective PDE4 inhibitors, which inhibit all four subtypes simultaneously, produce many promising therapeutic benefits, such as anti-inflammatory or cognition- and memory-enhancing effects. However, unwanted side effects, principally, nausea, diarrhea, and emesis, have long hampered their clinical and commercial success. Targeting individual PDE4 subtypes has been proposed for developing drugs with an improved safety profile, but which PDE4 subtype(s) is/are actually responsible for nausea and emesis remains ill defined. In mice treated with PAN-selective inhibitors, there is substantial …
Deficits In Health Literacy And Inadequacies Of Specialized Health Care In The South For Deaf And Hard Of Hearing Patients, Kaleb Kittrell
Deficits In Health Literacy And Inadequacies Of Specialized Health Care In The South For Deaf And Hard Of Hearing Patients, Kaleb Kittrell
Honors Theses
Health literacy is a constantly evolving concept that requires similarly evolving adaptation and specialization of health care to increase the quality of life for all. One demographic that is largely ignored when it comes to research in health literacy, specifically in the traditional South, is the d/Deaf and hard of hearing/Hard of Hearing (DHH) population. The purpose of this study is to determine the general health literacy of this specific demographic and compare results with that of other demographics to highlight the anticipated deficit in health literacy levels and emphasize the critical need for specialized care. This prospective, non-experimental, descriptive …
Applying Mci-062, A Novel Pan-Ras Inhibitor, To Treat Kras-Mutant Lung Cancer, Richard Fu
Applying Mci-062, A Novel Pan-Ras Inhibitor, To Treat Kras-Mutant Lung Cancer, Richard Fu
Honors Theses
RAS is a prevalent oncogene that is mutated in 27% of human cancers. Gain-of-function RAS mutations activate multiple downstream pathways, including the RAS-RAF-MEK-ERK and PI3K/AKT/mTOR pathways, which are critical in tumorigenesis and cancer cell proliferation. RAS proteins such as KRAS, a member of the RAS protein family, and their downstream effectors are attractive targets for cancer therapy since their mutations act as frequent drivers in lung, colorectal, and pancreatic cancers. However, RAS proteins have relatively smooth surfaces that lack traditional binding pockets, making inhibitors specific to RAS difficult to create. Recently, a novel small molecule pan-RAS inhibitor named MCI-062 was …