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Assessment Of Particulate Matter Toxicity And Physicochemistry At The Claim 28 Uranium Mine Site In Blue Gap, Az, Jessica G. Begay
Assessment Of Particulate Matter Toxicity And Physicochemistry At The Claim 28 Uranium Mine Site In Blue Gap, Az, Jessica G. Begay
Biomedical Sciences ETDs
Particulate matter (PM) inhalation is known to have adverse effects on the respiratory and cardiovascular systems. Community concerns in the southwestern US have been expressed in regions of extensive open-pit hard-rock (especially uranium) mining that windblown dusts may pose an excess health risk. To address these concerns, we have undertaken a campaign to detail: (1) the amount and composition of the PM2.5 in the region, (2) meteorological characteristics, such as wind speed and direction, and (3) and immunological and physiological responses of mice after PM2.5 exposures.
For toxicity studies, C57BL/6 and apolipoprotein E-null (ApoE-/-, a vascular …