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'Nephrogenic' Systemic Fibrosis Is Mediated By Myeloid C-C Chemokine Receptor 2 Dataset, Catherine Do, Viktor Drel, Chunyan Tan, Duck-Yoon Lee, Brent Wagner

The Kidney Institute of New Mexico

This dataset presents results of an in vivo model of gadolinium-based contrast agent-induced systemic fibrosis. Figure 1 demonstrates that gadolinium-based contrast agent treatment induces dermal fibrosis and hypercellularity of the same magnitude in patients afflicted with ‘nephrogenic’ systemic fibrosis. Electron microscopy demonstrated that systemic gadolinium treatment induced the formation of multinucleated giant cells in the dermis laden with electron-dense, mesh-like nanostructures. Scanning transmission electron microscopy with energy-dispersive spectroscopy revealed that the electron-dense nanoparticles were gadolinium rich. Figure 2 represents the first chimeric model of mice and gadolinium-induced systemic fibrosis (to our knowledge). Lethally-irradiated mice with 5/6 nephrectomy (to model renal …