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Full-Text Articles in Medicine and Health Sciences
Assessment Of Post-Discharge Health Care Utilization In Infants With Neonatal Opioid Withdrawal Syndrome, Shikhar Shrestha
Assessment Of Post-Discharge Health Care Utilization In Infants With Neonatal Opioid Withdrawal Syndrome, Shikhar Shrestha
Pharmaceutical Sciences ETDs
Background/Objectives: Children born to mothers with opioid use disorder often show withdrawal effects characterized by increased stress, hyperirritability, tremors, tachycardia, sleep deprivation, and gastrointestinal discomfort, commonly known as “neonatal opioid withdrawal syndrome” (NOWS). Studies have shown that the effect of NOWS can lead to several health-related disorders later in life leading to increased health care utilization. However, detailed study of post-discharge health care utilization, specifically focusing on encounters with the health care system is currently lacking in the literature. Our objective was to evaluate health care utilization in infants who were diagnosed with NOWS during a one-year follow-up period after …
Strategies To Combat Drug-Resistant Tuberculosis: Inhalable Microparticles Formulated With Anti-Tubercular Antibiotics And Efflux Pump Inhibitors, Elliott K. Miller
Strategies To Combat Drug-Resistant Tuberculosis: Inhalable Microparticles Formulated With Anti-Tubercular Antibiotics And Efflux Pump Inhibitors, Elliott K. Miller
Pharmaceutical Sciences ETDs
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen which can remain dormant within the human body for years (latent tuberculosis), and once active requires extensive multidrug therapies for treatment. Long-term antibiotic(s) exposure have led to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains which require novel treatment approaches to combat Mtb resistance. Mtb may also utilize efflux pumps to expel antibiotics and promote bacterial survival, potentially mediating drug tolerance, which has been hypothesized to contribute to antibiotic resistance. Efflux pump inhibitors (EPIs) such as verapamil (VER) may potentiate effects of first-line anti-tubercular drugs (ATDs) such as rifampicin …
Biphasic Effects Of Vanadium Sulfate On Cerebrovascular Endothelial Cell Barrier Integrity, Yoselin Ordonez Suarez
Biphasic Effects Of Vanadium Sulfate On Cerebrovascular Endothelial Cell Barrier Integrity, Yoselin Ordonez Suarez
Pharmaceutical Sciences ETDs
The objective of this study was to investigate the biphasic effects of vanadyl sulfate in cerebral vascular endothelial cells with a focus on understanding the mechanisms underlying vanadyl sulfate benefits. To first address the effects of vanadyl sulfate on endothelial permeability, mouse cerebrovascular endothelial cells were grown to confluence in 96-well electrode ECIS plates and treated with three different vanadium containing compounds: vanadyl sulfate, vanadium pentoxide, and ammonium metavanadate. Resistance of the endothelial cell monolayer was measured at 4kHz for 24 hours for different concentrations of vanadium containing compounds. The mouse cerebrovascular endothelial cells were also treated with different concentrations …
Serotonin Syndrome And/Or Opioid Withdrawal After The First Dose Of Naltrexone Hcl/Bupropion Hcl: An Observational Study, Stefanie J. Logothetis
Serotonin Syndrome And/Or Opioid Withdrawal After The First Dose Of Naltrexone Hcl/Bupropion Hcl: An Observational Study, Stefanie J. Logothetis
Pharmaceutical Sciences ETDs
In 2014, the Food and Drug Administration approved naltrexone HCl/bupropion HCl, a combination of an antidepressant and an opioid antagonist for chronic weight management therapy. Concurrent use of antidepressants and opioids has the potential to cause drug interactions involving serotonin syndrome. Our primary objective is to identify cases of serotonin syndrome and/or opioid withdrawal after initiation of naltrexone HCl/bupropion HCl. Our secondary objective is to assess which specific opioids are more likely to cause a drug interaction with naltrexone HCl/bupropion HCl. We performed an observational study by reviewing cases in the RADARS® database from January 2014 through December 2018. …