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Full-Text Articles in Medicine and Health Sciences
Pathogenicity In Chickens And Turkeys Of A 2021 United States H5n1 Highly Pathogenic Avian Influenza Clade 2.3.4.4b Wild Bird Virus Compared To Two Previous H5n8 Clade 2.3.4.4 Viruses, Mary J. Pantin-Jackwood, Erica Spackman, Christina Leyson, Sungsu Youk, Scott A. Lee, Linda M. Moon, Mia K. Torchetti, Mary L. Killian, Julianna B. Lenoch, Darrell R. Kapczynski, David E. Swayne, David L. Suarez
Pathogenicity In Chickens And Turkeys Of A 2021 United States H5n1 Highly Pathogenic Avian Influenza Clade 2.3.4.4b Wild Bird Virus Compared To Two Previous H5n8 Clade 2.3.4.4 Viruses, Mary J. Pantin-Jackwood, Erica Spackman, Christina Leyson, Sungsu Youk, Scott A. Lee, Linda M. Moon, Mia K. Torchetti, Mary L. Killian, Julianna B. Lenoch, Darrell R. Kapczynski, David E. Swayne, David L. Suarez
USDA Wildlife Services: Staff Publications
Highly pathogenic avian influenza viruses (HPAIVs) of subtype H5 of the Gs/GD/96 lineage remain a major threat to poultry due to endemicity in wild birds. H5N1 HPAIVs from this lineage were detected in 2021 in the United States (US) and since then have infected many wild and domestic birds. We evaluated the pathobiology of an early US H5N1 HPAIV (clade 2.3.4.4b, 2021) and two H5N8 HPAIVs from previous outbreaks in the US (clade 2.3.4.4c, 2014) and Europe (clade 2.3.4.4b, 2016) in chickens and turkeys. Differences in clinical signs, mean death times (MDTs), and virus transmissibility were found between chickens and …
Limited Accumulation And Persistence Of An Influenza A Virus In Tadpole Snails (Physa Spp.), Paul T. Oesterle, J. Jeffrey Root, Darcy S.O. Mora, Heather Schneider, Alan B. Franklin, Kathryn P. Huyvaert
Limited Accumulation And Persistence Of An Influenza A Virus In Tadpole Snails (Physa Spp.), Paul T. Oesterle, J. Jeffrey Root, Darcy S.O. Mora, Heather Schneider, Alan B. Franklin, Kathryn P. Huyvaert
USDA Wildlife Services: Staff Publications
Waterfowl infected with avian influenza A viruses (IAVs) shed infectious virus into aquatic environments, providing a mechanism for transmission among waterfowl, while also exposing the entire aquatic ecosystem to the virus. Aquatic invertebrates such as freshwater snails are likely exposed to IAVs in the water column and sediment. Freshwater snails comprise a significant portion of some waterfowl species’ diets, so this trophic interaction may serve as a novel route of IAV transmission. In these experiments, tadpole snails (Physa spp.) were exposed to a low-pathogenicity IAV (H3N8) to determine whether snails can accumulate the virus and, if so, how long virus …
H7n9 Influenza A Virus Transmission In A Multispecies Barnyard Model, Angela M. Bosco-Lauth, Anna Rodriguez, Rachel M. Maison, Stephanie M. Porter, J. Jeffrey Root
H7n9 Influenza A Virus Transmission In A Multispecies Barnyard Model, Angela M. Bosco-Lauth, Anna Rodriguez, Rachel M. Maison, Stephanie M. Porter, J. Jeffrey Root
USDA Wildlife Services: Staff Publications
Influenza A viruses are a diverse group of pathogens that have been responsible for millions of human and avian deaths throughout history. Here, we illustrate the transmission potential of H7N9 influenza A virus between Coturnix quail (Coturnix sp.), domestic ducks (Anas platyrhynchos domesticus), chickens (Gallus gallus domesticus), and house sparrows (Passer domesticus) co-housed in an artificial barnyard setting. In each of four replicates, individuals from a single species were infected with the virus. Quail shed virus orally and were a source of infection for both chickens and ducks. Infected chickens transmitted the virus to quail but not to ducks or …
Social Network Analysis Of White-Tailed Deer Scraping Behavior: Implications For Disease Transmission, Michael E. Egan, Kim M. Pepin, Justin Fischer, Scott R. Hygnstrom, Kurt C. Vercauteren, Guillaume Bastille-Rousseau
Social Network Analysis Of White-Tailed Deer Scraping Behavior: Implications For Disease Transmission, Michael E. Egan, Kim M. Pepin, Justin Fischer, Scott R. Hygnstrom, Kurt C. Vercauteren, Guillaume Bastille-Rousseau
USDA Wildlife Services: Staff Publications
Host contact structure affects pathogen transmission in host populations, but many measures of host contact do not distinguish contacts that are relevant to pathogen transmission from those that are not. Scrapes are sites for chemical communication by white-tailed deer (Odocoileus virginianus) during the breeding season and potential sites of transmission of prions, the causative agent of chronic wasting disease (CWD). Scrape-related behaviors vary in their probability of transmitting prions to or from the environment, suggesting that behavior be combined with contact structure to better reflect potential heterogeneity in prion transmission at scrapes. We recorded visits and behaviors by …
Strength In Numbers: Avian Influenza A Virus Transmission To Poultry From A Flocking Passerine, J. Jeffrey Root, Jeremy W. Ellis, Susan A. Shriner
Strength In Numbers: Avian Influenza A Virus Transmission To Poultry From A Flocking Passerine, J. Jeffrey Root, Jeremy W. Ellis, Susan A. Shriner
USDA Wildlife Services: Staff Publications
The effects of flock size of European starlings (Sturnus vulgaris) was experimentally manipulated to assess the potential of influenza A virus (IAV; H4N6) transmission from a flocking passerine to bobwhite quail (Colinus virginianus) through shared food and water resources to mimic starling intrusions into free-range and backyard poultry operations. Of the three starling flock sizes tested (n = 30, n = 20 and n = 10), all successfully transmitted the virus to all or most of the quail in each animal room (6/6, 6/6 and 5/6) by the end of the experimental period, as determined by seroconversion and/or viral RNAshedding. …
A Model For Leveraging Animal Movement To Understand Spatio-Temporal Disease Dynamics, Mark Q. Wilber, Anni Yang, Raoul Boughton, Kezia R. Manlove, Ryan S. Miller, Kim M. Pepin, George Wittemyer
A Model For Leveraging Animal Movement To Understand Spatio-Temporal Disease Dynamics, Mark Q. Wilber, Anni Yang, Raoul Boughton, Kezia R. Manlove, Ryan S. Miller, Kim M. Pepin, George Wittemyer
USDA Wildlife Services: Staff Publications
The ongoing explosion of fine-resolution movement data in animal systems provides a unique opportunity to empirically quantify spatial, temporal and individual variation in transmission risk and improve our ability to forecast disease outbreaks. However, we lack a generalizable model that can leverage movement data to quantify transmission risk and how it affects pathogen invasion and persistence on heterogeneous landscapes. We developed a flexible model ‘Movement-driven modelling of spatio-temporal infection risk’ (MoveSTIR) that leverages diverse data on animal movement to derive metrics of direct and indirect contact by decomposing transmission into constituent processes of contact formation and duration and pathogen deposition …
How Do Genetic Relatedness And Spatial Proximity Shape African Swine Fever Infections In Wild Boar?, Tomasz Podgórski, Kim M. Pepin, Anna Radko, Angelika Podbielska, Magdalena Łyjak, Grzegorz Woźniakowski, Tomasz Borowik
How Do Genetic Relatedness And Spatial Proximity Shape African Swine Fever Infections In Wild Boar?, Tomasz Podgórski, Kim M. Pepin, Anna Radko, Angelika Podbielska, Magdalena Łyjak, Grzegorz Woźniakowski, Tomasz Borowik
USDA Wildlife Services: Staff Publications
The importance of social and spatial structuring of wildlife populations for disease spread, though widely recognized, is still poorly understood in many host-pathogen systems. In particular, system-specific kin relationships among hosts can create contact heterogeneities and differential disease transmission rates. Here, we investigate how distance-dependent infection risk is influenced by genetic relatedness in a novel host-pathogen system: wild boar (Sus scrofa) and African swine fever (ASF).We hypothesized that infection risk would correlate positively with proximity and relatedness to ASF-infected individuals but expected those relationships to weaken with the distance between individuals due to decay in contact rates and …
Variation In Angiostrongylus Cantonensis Infection In Definitive And Intermediate Hosts In Hawaii, A Global Hotspot Of Rat Lungworm Disease, Chris Niebuhr, Shane R. Siers, Israel Leinbach, Lisa M. Kaluna, Susan I. Jarvi
Variation In Angiostrongylus Cantonensis Infection In Definitive And Intermediate Hosts In Hawaii, A Global Hotspot Of Rat Lungworm Disease, Chris Niebuhr, Shane R. Siers, Israel Leinbach, Lisa M. Kaluna, Susan I. Jarvi
USDA Wildlife Services: Staff Publications
Angiostrongylus cantonensis (rat lungworm) is a tropical and subtropical parasitic nematode, with infections in humans causing angiostrongyliasis (rat lungworm disease), characterized by eosinophilic meningitis. Hawaii has been identified as a global hotspot of infection, with recent reports of high infection rates in humans, as well as rat definitive and snail intermediate hosts. This study investigated variation in A. cantonensis infection, both prevalence and intensity, in wild populations of two species of rats (Rattus exulans and R. rattus) and one species of snail (Parmarion martensi). An overall infection prevalence of 86.2% was observed in P. martensi and …
Effects Of Freshwater Crayfish On Influenza A Virus Persistence In Water, J. Jeffrey Root, Jeremy W. Ellis, Susan A. Shriner
Effects Of Freshwater Crayfish On Influenza A Virus Persistence In Water, J. Jeffrey Root, Jeremy W. Ellis, Susan A. Shriner
USDA Wildlife Services: Staff Publications
Several investigations have recently assessed the ability of some aquatic invertebrates to act as tools for avian influenza A virus (IAV) surveillance as well as their potential role(s) in IAV ecology. Because of this, as well as the high IAV seroprevalence rates noted in select mesocarnivores that commonly inhabit aquatic and semi-aquatic habitats, we evaluated the effects that freshwater crayfish have on IAV in water at three dose levels and monitored for the presence of IAV in crayfish tissues (gill and green gland) and haemolymph at multiple time points. At relatively high, medium 432 and low (approximately 10 , 10 …
Ecological Drivers Of African Swine Fever Virus Persistence In Wild Boar Populations: Insight For Control, Kim M. Pepin, Andrew J. Golnar, Zaid Abdo, Tomasz Podgórski
Ecological Drivers Of African Swine Fever Virus Persistence In Wild Boar Populations: Insight For Control, Kim M. Pepin, Andrew J. Golnar, Zaid Abdo, Tomasz Podgórski
USDA Wildlife Services: Staff Publications
Environmental sources of infection can play a primary role in shaping epidemiological dynamics; however, the relative impact of environmental transmission on host-pathogen systems is rarely estimated. We developed and fit a spatially explicit model of African swine fever virus (ASFV) in wild boar to estimate what proportion of carcassbased transmission is contributing to the low-level persistence of ASFV in Eastern European wild boar. Our model was developed based on ecological insight and data from field studies of ASFV and wild boar in Eastern Poland. We predicted that carcass- based transmission would play a substantial role in persistence, especially in low-density …
Influenza A Viruses In Peridomestic Mammals, J. Jeffrey Root, Susan A. Shriner
Influenza A Viruses In Peridomestic Mammals, J. Jeffrey Root, Susan A. Shriner
USDA Wildlife Services: Staff Publications
During recent years, serological evidence has shown that a number of peridomestic mammals (e.g., those commonly found in or around human structures) are naturally exposed to influenza A viruses (IAVs). In addition, experimental studies have demonstrated that many of these species can successfully replicate several different IAVs, including IAVs of high consequence to public or agricultural health. The replication of some IAVs within this group of mammals could have implications for biosecurity associated with poultry production and live bird markets in some regions of the world. Given this evidence, the need for further study and understanding of the role that …
Tissue Tropisms Of Avian Influenza A Viruses Affect Their Spillovers From Wild Birds To Pigs, Xiaojian Zhang, Fred L. Cunningham, Lei Li, Katie Hanson-Dorr, Liyuan Liu, Kaitlyn Waters, Minhui Guan, Alicia K. Olivier, Brandon S. Schmit, Jacqueline M. Nolting, Andrew S. Bowman, Mia Kim Torchetti, Thomas J. Deliberto, Xiu-Feng Wan
Tissue Tropisms Of Avian Influenza A Viruses Affect Their Spillovers From Wild Birds To Pigs, Xiaojian Zhang, Fred L. Cunningham, Lei Li, Katie Hanson-Dorr, Liyuan Liu, Kaitlyn Waters, Minhui Guan, Alicia K. Olivier, Brandon S. Schmit, Jacqueline M. Nolting, Andrew S. Bowman, Mia Kim Torchetti, Thomas J. Deliberto, Xiu-Feng Wan
USDA Wildlife Services: Staff Publications
Wild aquatic birds maintain a large, genetically diverse pool of influenza A viruses (IAVs), which can be transmitted to lower mammals and, ultimately, humans. Through phenotypic analyses of viral replication efficiency, only a small set of avian IAVs were found to replicate well in epithelial cells of the swine upper respiratory tract, and these viruses were shown to infect and cause virus shedding in pigs. Such a phenotypic trait of the viral replication efficiency appears to emerge randomly and is distributed among IAVs across multiple avian species and geographic and temporal orders. It is not determined by receptor binding preference …
Confronting Models With Data: The Challenges Of Estimating Disease Spillover, Paul C. Cross, Diann J. Prosser, Andrew M. Ramey, Ephraim M. Hanks, Kim M. Pepin
Confronting Models With Data: The Challenges Of Estimating Disease Spillover, Paul C. Cross, Diann J. Prosser, Andrew M. Ramey, Ephraim M. Hanks, Kim M. Pepin
USDA Wildlife Services: Staff Publications
For pathogens known to transmit across host species, strategic investment in disease control requires knowledge about where and when spillover transmission is likely. One approach to estimating spillover is to directly correlate observed spillover events with covariates. An alternative is to mechanistically combine information on host density, distribution and pathogen prevalence to predict where and when spillover events are expected to occur. We use several case studies at the wildlife–livestock disease interface to highlight the challenges, and potential solutions, to estimating spatiotemporal variation in spillover risk. Datasets on multiple host species often do not align in space, time or resolution, …