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Articles 1 - 20 of 20
Full-Text Articles in Medicine and Health Sciences
A Virtual Reality Platform For The Measurement Of Drinking Topography, Victor Schneider, Nicholas Bush, Darya Vitus, Ryan Carpenter, Michael Robinson, Jeff Boissoneault
A Virtual Reality Platform For The Measurement Of Drinking Topography, Victor Schneider, Nicholas Bush, Darya Vitus, Ryan Carpenter, Michael Robinson, Jeff Boissoneault
Psychology Faculty Works
BackgroundThe assessment of alcohol consumption during a drinking bout, known as drinking topography, may help improve understanding of biopsychosocial mechanisms underlying alcohol consumption. However, past studies have been limited by effort-intensive, time-consuming, and error-prone processes involved in collecting, organizing, and standardizing drinking topography data. Recent technologies allowing integrated data collection and greater environmental control, such as virtual reality (VR), could resolve these problems.MethodsIn this pilot project, we assessed alcohol consumption topography of participants in a VR drinking environment with a programmable virtual confederate (i.e., bar goer) during two testing sessions. In one, the confederate drank quickly (30-60 s sip interval). …
A Prospective Examination Of Sex Differences In Posttraumatic Autonomic Functioning, Antonia Seligowski, Elizabeth Steuber, Rebecca Hinrichs, Mariam Reda, Charis Wiltshire, Cassandra Wanna, Sterling Winters, Karlye Phillips, Stacey House, Francesca Beaudoin, Xinming An, Jennifer Stevens, Donglin Zeng, Thomas Neylan, Gari Clifford, Sarah Linnstaedt, Laura Germine, Kenneth Bollen, Guia Guffanti, Scott Rauch, John Haran, Alan Storrow, Brittany Punches, Michael Kurz, Vishnu Murty, Meghan Mcgrath, Lauren Hudak, Jose Pascual, Mark Seamon, Elizabeth Datner, Anna Marie Chang, Claire Pearson, David Peak, Roland Merchant, Robert Domeier, Niels Rathlev, Brian O'Neil, Leon Sanchez, Steven Bruce, Mark Miller, Robert Pietrzak, Jutta Joormann, Deanna Barch, Diego Pizzagalli, John Sheridan, Beatriz Luna, Steven Harte, James Elliott, Karestan Koenen, Ronald Kessler, Samuel Mclean, Kerry Ressler, Tanja Jovanovic
A Prospective Examination Of Sex Differences In Posttraumatic Autonomic Functioning, Antonia Seligowski, Elizabeth Steuber, Rebecca Hinrichs, Mariam Reda, Charis Wiltshire, Cassandra Wanna, Sterling Winters, Karlye Phillips, Stacey House, Francesca Beaudoin, Xinming An, Jennifer Stevens, Donglin Zeng, Thomas Neylan, Gari Clifford, Sarah Linnstaedt, Laura Germine, Kenneth Bollen, Guia Guffanti, Scott Rauch, John Haran, Alan Storrow, Brittany Punches, Michael Kurz, Vishnu Murty, Meghan Mcgrath, Lauren Hudak, Jose Pascual, Mark Seamon, Elizabeth Datner, Anna Marie Chang, Claire Pearson, David Peak, Roland Merchant, Robert Domeier, Niels Rathlev, Brian O'Neil, Leon Sanchez, Steven Bruce, Mark Miller, Robert Pietrzak, Jutta Joormann, Deanna Barch, Diego Pizzagalli, John Sheridan, Beatriz Luna, Steven Harte, James Elliott, Karestan Koenen, Ronald Kessler, Samuel Mclean, Kerry Ressler, Tanja Jovanovic
Psychology Faculty Works
BackgroundCross-sectional studies have found that individuals with posttraumatic stress disorder (PTSD) exhibit deficits in autonomic functioning. While PTSD rates are twice as high in women compared to men, sex differences in autonomic functioning are relatively unknown among trauma-exposed populations. The current study used a prospective design to examine sex differences in posttraumatic autonomic functioning.Methods192 participants were recruited from emergency departments following trauma exposure (Mean age = 35.88, 68.2% female). Skin conductance was measured in the emergency department; fear conditioning was completed two weeks later and included measures of blood pressure (BP), heart rate (HR), and high frequency heart rate variability …
Development And Validation Of A Model To Predict Posttraumatic Stress Disorder And Major Depression After A Motor Vehicle Collision, Steven Bruce, Hannah Ziobrowski, Chris Kennedy, Berk Ustun, Stacey House, Francesca Beaudoin, Xinming An, Donglin Zeng, Kenneth Bollen, Maria Petukhova, Nancy Sampson, Victor Puac-Polanco, Sue Lee, Karestan Koenen, Kerry Ressler, Samuel Mclean, Ronald Kessler, Aurora Consortium
Development And Validation Of A Model To Predict Posttraumatic Stress Disorder And Major Depression After A Motor Vehicle Collision, Steven Bruce, Hannah Ziobrowski, Chris Kennedy, Berk Ustun, Stacey House, Francesca Beaudoin, Xinming An, Donglin Zeng, Kenneth Bollen, Maria Petukhova, Nancy Sampson, Victor Puac-Polanco, Sue Lee, Karestan Koenen, Kerry Ressler, Samuel Mclean, Ronald Kessler, Aurora Consortium
Psychology Faculty Works
Importance A substantial proportion of the 40 million people in the US who present to emergency departments (EDs) each year after traumatic events develop posttraumatic stress disorder (PTSD) or major depressive episode (MDE). Accurately identifying patients at high risk in the ED would facilitate the targeting of preventive interventions.Objectives To develop and validate a prediction tool based on ED reports after a motor vehicle collision to predict PTSD or MDE 3 months later.Design, Setting, and Participants The Advancing Understanding of Recovery After Trauma (AURORA) study is a longitudinal study that examined adverse posttraumatic neuropsychiatric sequalae among patients who presented to …
Efficacy Of The Idbt-Pain Skills Training Intervention To Reduce Emotional Dysregulation And Pain Intensity In People With Chronic Pain: Protocol For A Single-Case Experimental Design With Multiple Baselines., Nell Norman-Nott, Chelsey Wilks, Negin Hesam-Shariati, Negin Hesam-Shariati, Jessica Schroeder, Jina Suh, Jina Suh, Mary Czerwinski, Sylvia Gustin
Efficacy Of The Idbt-Pain Skills Training Intervention To Reduce Emotional Dysregulation And Pain Intensity In People With Chronic Pain: Protocol For A Single-Case Experimental Design With Multiple Baselines., Nell Norman-Nott, Chelsey Wilks, Negin Hesam-Shariati, Negin Hesam-Shariati, Jessica Schroeder, Jina Suh, Jina Suh, Mary Czerwinski, Sylvia Gustin
Psychology Faculty Works
Introduction Difficulties in emotional regulation are key to the development and maintenance of chronic pain. Recent evidence shows internet-delivered dialectic behaviour therapy (iDBT) skills training can reduce emotional dysregulation and pain intensity. However, further studies are needed to provide more definitive evidence regarding the efficacy of iDBT skills training in the chronic pain population. Methods and analysis A single-case experimental design (SCED) with multiple baselines will be used to examine the efficacy of a 4-week iDBT-Pain skills training intervention (iDBT-Pain intervention) to reduce emotional dysregulation and pain intensity in individuals with chronic pain. The iDBT-Pain intervention encompasses two components: (1) …
Smartphone Applications Targeting Borderline Personality Disorder Symptoms: A Systematic Review And Meta-Analysis., Gabrielle Ilagan, Evan Iliakis, Chelsey Wilks, Ipsit Vahia, Ipsit Vahia, Lois Choi-Kain, Lois Choi-Kain
Smartphone Applications Targeting Borderline Personality Disorder Symptoms: A Systematic Review And Meta-Analysis., Gabrielle Ilagan, Evan Iliakis, Chelsey Wilks, Ipsit Vahia, Ipsit Vahia, Lois Choi-Kain, Lois Choi-Kain
Psychology Faculty Works
Background: Smartphone applications could improve symptoms of borderline personality disorder (BPD) in a scalable and resource-efficient manner in the context limited access to specialized care. Objective: This systematic review and meta-analysis aims to evaluate the effectiveness of applications designed as treatment interventions for adults with symptoms such as anger, suicidality, or self-harm that commonly occur in BPD. Data sources: Search terms for BPD symptoms, smartphone applications, and treatment interventions were combined on PubMed, MEDLINE, and PsycINFO from database inception to December 2019. Study selection: Controlled and uncontrolled studies of smartphone interventions for adult participants with symptoms such as anger, suicidality, …
Dataset: Assessment Of Vigilance Performance And/Or Reliance On Automated Decision Aids: An X-Ray Screening Task, Stephanie Merritt, Lei Shirase, Garett Foster
Dataset: Assessment Of Vigilance Performance And/Or Reliance On Automated Decision Aids: An X-Ray Screening Task, Stephanie Merritt, Lei Shirase, Garett Foster
Psychology Faculty Works
A great deal of interest concerns the study of vigilance performance and trust in automation due to their implications for public safety. The present work contributes to this literature by providing an experimental resource for scholars in need of a vigilance style task. We created a set of 150 stimuli that may be downloaded and used by researchers in future data collections. These stimuli are X-ray images of luggage, and participants indicate whether or not they believe each image contains a dangerous item (simulating airport security screening). Using a sample of 990 adults recruited via MTurk, we normed these items …
Education As Important Predictor For Successful Employment In Adults With Congenital Heart Disease Worldwide., Maayke Sluman, Maayke Sluman, Silke Apers, Judith Sluiter, Karen Nieuwenhuijsen, Philip Moons, Philip Moons, Koen Luyckx, Koen Luyckx, Adrienne Kovacs, Adrienne Kovacs, Corina Thomet, Werner Budts, Junko Enomoto, Hsiao-Ling Yang, Jamie Jackson, Paul Khairy, Stephen Cook, Raghavan Subramanyan, Luis Alday, Katrine Eriksen, Mikael Dellborg, Mikael Dellborg, Malin Berghammer, Malin Berghammer, Eva Mattsson, Andrew Mackie, Samuel Menahem, Maryanne Caruana, Kathy Gosney, Alexandra Soufi, Susan Fernandes, Kamila White, Edward Callus, Shelby Kutty, Berto Bouma, Barbara Mulder
Education As Important Predictor For Successful Employment In Adults With Congenital Heart Disease Worldwide., Maayke Sluman, Maayke Sluman, Silke Apers, Judith Sluiter, Karen Nieuwenhuijsen, Philip Moons, Philip Moons, Koen Luyckx, Koen Luyckx, Adrienne Kovacs, Adrienne Kovacs, Corina Thomet, Werner Budts, Junko Enomoto, Hsiao-Ling Yang, Jamie Jackson, Paul Khairy, Stephen Cook, Raghavan Subramanyan, Luis Alday, Katrine Eriksen, Mikael Dellborg, Mikael Dellborg, Malin Berghammer, Malin Berghammer, Eva Mattsson, Andrew Mackie, Samuel Menahem, Maryanne Caruana, Kathy Gosney, Alexandra Soufi, Susan Fernandes, Kamila White, Edward Callus, Shelby Kutty, Berto Bouma, Barbara Mulder
Psychology Faculty Works
Background: Conflicting results have been reported regarding employment status and work ability in adults with congenital heart disease (CHD). Since this is an impor‐ tant determinant for quality of life, we assessed this in a large international adult CHD cohort. Methods: Data from 4028 adults with CHD (53% women) from 15 different countries were collected by a uniform survey in the cross‐sectional APPROACH International Study. Predictors for employment and work limitations were studied using general linear mixed models. Results: Median age was 32 years (IQR 25‐42) and 94% of patients had at least a high school degree. Overall employment rate …
Geographical Variation And Predictors Of Physical Activity Level In Adults With Congenital Heart Disease., Lena Larsson, Bengt Johansson, Camilla Sandberg, Silke Apers, Adrienne Kovacs, Koen Luyckx, Corina Thomet, Werner Budts, Junko Enomoto, Maayke Sluman, Jou-Kou Wang, Jamie Jackson, Paul Khairy, Stephen Cook, Luis Alday, Katrine Eriksen, Mikael Dellborg, Malin Berghammer, Gwen Rempel, Samuel Menahem, Maryanne Caruana, Martha Tomlin, Alexandra Soufi, Susan Fernandes, Kamila White, Edward Callus, Shelby Kutty, Philip Moons
Geographical Variation And Predictors Of Physical Activity Level In Adults With Congenital Heart Disease., Lena Larsson, Bengt Johansson, Camilla Sandberg, Silke Apers, Adrienne Kovacs, Koen Luyckx, Corina Thomet, Werner Budts, Junko Enomoto, Maayke Sluman, Jou-Kou Wang, Jamie Jackson, Paul Khairy, Stephen Cook, Luis Alday, Katrine Eriksen, Mikael Dellborg, Malin Berghammer, Gwen Rempel, Samuel Menahem, Maryanne Caruana, Martha Tomlin, Alexandra Soufi, Susan Fernandes, Kamila White, Edward Callus, Shelby Kutty, Philip Moons
Psychology Faculty Works
Background: Physical activity is important to maintain and promote health. This is of particular interest in patients with congenital heart disease (CHD) where acquired heart disease should be prevented. The World Health Organization (WHO) recommends a minimum of 2.5 h/week of physical activity exceeding 3 metabolic equivalents (METS) to achieve positive health effects. It is unknown whether physical activity levels (PAL) in adult CHD patients differ by country of origin. Methods: 3896 adults with CHD recruited from 15 countries over 5 continents completed self-reported instruments, including the Health Behaviour Scale (HBS-CHD), within the APPROACH-IS project. For each patient, we calculated …
Mapping Abnormal Subcortical Neurodevelopment In A Cohort Of Thai Children With Hiv, Benjamin Wade, Benjamin Wade, Benjamin Wade, Victor Valcour, Thanyawee Puthanakit, Arvin Saremi, Boris Gutman, Talia Nir, Christa Watson, Linda Aurpibul, Kosalaraksa, Pradthana Ounchanum, Stephen Kerr, Netsiri Dumrongpisutikul, Pannee Visrutaratna, Jiraporn Srinakarin, Monthana Pothisri, Katherine Narr, Paul Thompson, Jintanat Ananworanich, Robert Paul, Neda Jahanshad
Mapping Abnormal Subcortical Neurodevelopment In A Cohort Of Thai Children With Hiv, Benjamin Wade, Benjamin Wade, Benjamin Wade, Victor Valcour, Thanyawee Puthanakit, Arvin Saremi, Boris Gutman, Talia Nir, Christa Watson, Linda Aurpibul, Kosalaraksa, Pradthana Ounchanum, Stephen Kerr, Netsiri Dumrongpisutikul, Pannee Visrutaratna, Jiraporn Srinakarin, Monthana Pothisri, Katherine Narr, Paul Thompson, Jintanat Ananworanich, Robert Paul, Neda Jahanshad
Psychology Faculty Works
Alterations in subcortical brain structures have been reported in adults with HIV and, to a lesser extent, pediatric cohorts. The extent of longitudinal structural abnormalities in children with perinatal HIV infection (PaHIV) remains unclear. We modeled subcortical morphometry from whole brain structural magnetic resonance imaging (1.5 T) scans of 43 Thai children with PaHIV (baseline age = 11.09±2.36 years) and 50 HIV− children (11.26±2.80 years) using volumetric and surface-based shape analyses. The PaHIV sample were randomized to initiate combination antiretroviral treatment (cART) when CD4 counts were 15–24% (immediate: n = 22) or when CD4 < 15% (deferred: n = 21). Follow-up scans were acquired approximately 52 weeks after baseline. Volumetric and shape descriptors capturing local thickness and surface area dilation were defined for the bilateral accumbens, amygdala, putamen, pallidum, thalamus, caudate, and hippocampus. Regression models adjusting for clinical and demographic variables examined between and within group differences in morphometry associated with HIV. We assessed whether baseline CD4 count and cART status or timing associated with brain maturation within the PaHIV group. All models were adjusted for multiple comparisons using the false discovery rate. A pallidal subregion was significantly thinner in children with PaHIV. Regional thickness, surface area, and volume of the pallidum was associated with CD4 count in children with PaHIV. Longitudinal morphometry was not associated with HIV or cART status or timing, however, the trajectory of the left pallidum volume was positively associated with baseline CD4 count. Our findings corroborate reports in adult cohorts demonstrating a high predilection for HIV-mediated abnormalities in the basal ganglia, but suggest the effect of stable PaHIV infection on morphological aspects of brain development may be subtle.
Internet-Delivered Dialectical Behavior Therapy Skills Training For Suicidal And Heavy Drinkers, Chelsey Wilks, Qingqing Yin, Sin Yee Ang, Brandon Matsumiya, Anita Lungu, Marsha Linehan
Internet-Delivered Dialectical Behavior Therapy Skills Training For Suicidal And Heavy Drinkers, Chelsey Wilks, Qingqing Yin, Sin Yee Ang, Brandon Matsumiya, Anita Lungu, Marsha Linehan
Psychology Faculty Works
Background: The need to develop effective and accessible interventions for suicidal individuals engaging in heavy episodic drinking (HED) cannot be understated. While the link between alcohol use and suicidality is a complex one that remains to be elucidated, emotion dysregulation may play a key role in alcohol-related suicide risk in these individuals. Objective: In the current study, an 8-week Internet-delivered dialectical behavior therapy (DBT) skills training intervention was developed and preliminarily evaluated for suicidal individuals who engage in HED to regulate emotions. The aim of the study is to evaluate the feasibility and effectiveness of the therapist-assisted and Internet-delivered intervention, …
Structural And Functional Brain Imaging In Acute Hiv, Vishal Samboju, Carissa Philippi, Phillip Chan, Yann Cobigo, James Fletcher, Merlin Robb, Merlin Robb, Joanna Hellmuth, Khunthalee Benjapornpong, Netsiri Dumrongpisutikul, Mantana Pothisri, Robert Paul, Jintanat Ananworanich, Serena Spudich, Victor Valcour, Rv Teams
Structural And Functional Brain Imaging In Acute Hiv, Vishal Samboju, Carissa Philippi, Phillip Chan, Yann Cobigo, James Fletcher, Merlin Robb, Merlin Robb, Joanna Hellmuth, Khunthalee Benjapornpong, Netsiri Dumrongpisutikul, Mantana Pothisri, Robert Paul, Jintanat Ananworanich, Serena Spudich, Victor Valcour, Rv Teams
Psychology Faculty Works
Background:HIV RNA is identified in cerebrospinalfluid (CSF) within eightdays of estimated viral exposure. Neurological findings and impaired neuropsychological testing performance are documented in a subset of individuals with acuteHIV infection (AHI). The purpose of this study was to determine whether microstructural white matter and resting-state functional connectivity (rsFC) are disruptedin AHI.Methods:We examined 49 AHI (100% male; mean age = 30 ± SD 9.9) and 23 HIV-uninfected Thai participants (78% male; age = 30 ± 5.5) with diffusion tensor imaging (DTI) and rsFC acquired at 3 Tesla, and four neuropsychological tests (summarized as NPZ-4). MRI for the AHI group was performed …
Internet-Delivered Dialectical Behavioral Therapy Skills Training For Suicidal And Heavy Episodic Drinkers: Protocol And Preliminary Results Of A Randomized Controlled Trial., Chelsey Wilks, Qingqing Yin, Sin Ang, Brandon Matsumiya, Anita Lungu, Marsha Linehan
Internet-Delivered Dialectical Behavioral Therapy Skills Training For Suicidal And Heavy Episodic Drinkers: Protocol And Preliminary Results Of A Randomized Controlled Trial., Chelsey Wilks, Qingqing Yin, Sin Ang, Brandon Matsumiya, Anita Lungu, Marsha Linehan
Psychology Faculty Works
No abstract provided.
E-Health Intervention For Intergenerational Caregivers Of Chronically Ill Older Adults, A.M. Steffen, J. Epstein, K. Arenella
E-Health Intervention For Intergenerational Caregivers Of Chronically Ill Older Adults, A.M. Steffen, J. Epstein, K. Arenella
Psychology Faculty Works
Family-clinician communication is important for chronic disease self-management and improves outcomes for older adults and their family caregivers. In this e-health program based on principles from Social Cognitive Theory, adults assisting a parent with medical appointments and medication management were randomly assigned to one of two internet-based education interventions: (I.) Written didactics and video clips from medical experts, or (II.) Multimedia vignettes depicting actors responding to common healthcare challenges. Participants (N=136) had access to these materials for one month and completed pre- and post-intervention assessments. Post-intervention hierarchical regression analyses showed an intervention effect after controlling for pre-intervention scores. Relative to …
Cognitive Behavioral Therapy Increases Amygdala Connectivity With The Cognitive Control Network In Both Mdd And Ptsd, Haochang Shou, Zhen Yang, Theodore Satterthwaite, Philip Cook, Steven Bruce, Russell Shinohara, Benjamin Rosenberg, Yvette Sheline
Cognitive Behavioral Therapy Increases Amygdala Connectivity With The Cognitive Control Network In Both Mdd And Ptsd, Haochang Shou, Zhen Yang, Theodore Satterthwaite, Philip Cook, Steven Bruce, Russell Shinohara, Benjamin Rosenberg, Yvette Sheline
Psychology Faculty Works
BackgroundBoth major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) are characterized by alterations in intrinsic functional connectivity. Here we investigated changes in intrinsic functional connectivity across these disorders as a function of cognitive behavioral therapy (CBT), an effective treatment in both disorders.Methods53 unmedicated right-handed participants were included in a longitudinal study. Patients were diagnosed with PTSD (n = 18) and MDD (n = 17) with a structured diagnostic interview and treated with 12 sessions of manualized CBT over a 12-week period. Patients received an MRI scan (Siemens 3 T Trio) before and after treatment. Longitudinal functional principal components analysis …
Single-Session Dialectical Behavior Therapy Skills Training Versus Relaxation Training For Non-Treatment-Engaged Suicidal Adults: A Randomized Controlled Trial, Erin Ward-Ciesielski, Erin Ward-Ciesielski, Connor Jones, Madeline Wielgus, Chelsey Wilks, Marsha Linehan
Single-Session Dialectical Behavior Therapy Skills Training Versus Relaxation Training For Non-Treatment-Engaged Suicidal Adults: A Randomized Controlled Trial, Erin Ward-Ciesielski, Erin Ward-Ciesielski, Connor Jones, Madeline Wielgus, Chelsey Wilks, Marsha Linehan
Psychology Faculty Works
Background: Individuals who are not engaged in treatment are commonly overlooked in the design of intervention trials targeting suicidal populations as a result of recruitment methodology that requires individuals to be referred from their current provider. In fact, research suggests that the majority of individuals who die by suicide have not been in contact with mental health services in the year before their death. Methods/design: A randomized controlled trial of two brief, one-session interventions for adults who are not engaged in mental health treatment. Inclusion criteria include 1) 18 years or older, 2) experiencing suicidal ideation in the past week, …
Understanding The Complexity Of Biopsychosocial Factors In The Public Health Epidemic Of Overweight And Obesity, Diane Rosenbaum, Kamila White
Understanding The Complexity Of Biopsychosocial Factors In The Public Health Epidemic Of Overweight And Obesity, Diane Rosenbaum, Kamila White
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Obesity is a complex and multifaceted public health problem. This commentary reflects on a new theoretical model of obesity (i.e. Homeostatic Theory of Obesity proposed by Marks), and calls for additional research to examine biopsychosocial factors that may be of importance in developing interventions that promote long-term maintenance of weight loss and in developing obesity prevention programs. Furthermore, we discuss the role of socioeconomic factors in obesity and call for interdisciplinary efforts to address obesity risk factors in the interest of public health.
A Telehealth Behavioral Coaching Intervention For Neurocognitive Disorder Family Carers., Ann Steffen, Judith Gant
A Telehealth Behavioral Coaching Intervention For Neurocognitive Disorder Family Carers., Ann Steffen, Judith Gant
Psychology Faculty Works
No abstract provided.
Neuropsychological Outcomes In Adults Commencing Highly Active Anti-Retroviral Treatment In South Africa: A Prospective Study, John Joska, John Joska, Jennifer Westgarth-Taylor, Jacqueline Hoare, Kevin Thomas, Robert Paul, Landon Myer, Dan Stein
Neuropsychological Outcomes In Adults Commencing Highly Active Anti-Retroviral Treatment In South Africa: A Prospective Study, John Joska, John Joska, Jennifer Westgarth-Taylor, Jacqueline Hoare, Kevin Thomas, Robert Paul, Landon Myer, Dan Stein
Psychology Faculty Works
BackgroundInfection with HIV may result in significant neuropsychological impairment, especially in late stage disease. To date, there have been no cohort studies of the impact of highly active anti-retroviral treatment (HAART) in South Africa where clade C HIV is predominant.MethodsParticipants in the current study were recruited from a larger study of HIV-associated neurocognitive disorders (HAND) and included a group of individuals commencing HAART (n = 82). Baseline and one-year neuropsychological function was assessed using a detailed battery, and summary global deficit scores (GDS) obtained. Associations with change in GDS were calculated.ResultsParticipants had a median CD4 cell count of 166 at …
Damage To Association Fiber Tracts Impairs Recognition Of The Facial Expression Of Emotion, Carissa Philippi, Shruti Mehta, Thomas Grabowski, Ralph Adolphs, David Rudrauf
Damage To Association Fiber Tracts Impairs Recognition Of The Facial Expression Of Emotion, Carissa Philippi, Shruti Mehta, Thomas Grabowski, Ralph Adolphs, David Rudrauf
Psychology Faculty Works
No abstract provided.
Low Doses Of Memantine Disrupt Memory In Adult Rats, Catherine Creeley, David Wozniak, Joanne Labruyere, George Taylor, John Olney
Low Doses Of Memantine Disrupt Memory In Adult Rats, Catherine Creeley, David Wozniak, Joanne Labruyere, George Taylor, John Olney
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Memantine, a drug recently approved for treatment of Alzheimer’s disease, has been characterized as a unique NMDA antagonist that confers protection against excitotoxic neurodegeneration without the serious side effects that other NMDA antagonists are known to cause. In the present study, we determined what dose of memantine is required to protect the adult rat brain against an NMDA receptor-mediated excitotoxic process and then tested that dose and a range of lower doses to determine whether the drug in this dose range is associated with significant side effects. Consistent with previous research, we found that memantine confers a neuroprotective effect beginning …